Protein Alignment Nrt and CES4A

DIOPT Version :10

• Sequence 1: NP_476798.1
• Gene: Nrt / 39873
• FlyBaseID: FBgn0004108
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 140/601 - (23%)
• Similarity: 214/601 - (35%)
• Gaps: 189/601 - (31%)

  Fly   364 VTGCGPVEG----VKEDGAFAFRGIPYAKPPVDRLRWKPAEL------IDDINMC---WNDTLQT 415
            ||..|.::|    |.:.....|.|:|:::||:..||:.|.|.      |.|....   |:..| :
Human    53 VTKYGTLQGKQMHVGKTPIQVFLGVPFSRPPLGILRFAPPEPPEPWKGIRDATTYPPGWSLAL-S 116

  Fly   416 HNSSVVCTQRLGNGTTVG------------------------------------------DEDCL 438
            ...|.|...|| ..|:..                                          .||||
Human   117 PGWSAVARSRL-TATSASRVQASLLPQPLSIWGYRCLQESWGQLASMYVSTRERYKWLRFSEDCL 180

  Fly   439 YLDVVTPHVRYNNP-LPVVVLIGAESLAGPSPG---ILRPSARYSRS-----HDVIFVRPNFRLG 494
            ||:|..|.....:| |||:|..         ||   |:..::.|..|     ..|:.|....|||
Human   181 YLNVYAPARAPGDPQLPVMVWF---------PGGAFIVGAASSYEGSDLAAREKVVLVFLQHRLG 236

  Fly   495 VFGFLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVN 559
            :||||.....|.::|  ..||:.|.|.:|.|.|::.||..|||||.:|||.|..|||..::.|:.
Human   237 IFGFLRWRGRTDDSH--ARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMM 299

  Fly   560 SQKVKGLYTRAWASSGSAI----LPGKPLSESGK---------QNEQLMATLECADIQCLREASS 611
            |....||:.||.:.||:|:    :...||..:.|         .:.|::       :.|||..|.
Human   300 SPLASGLFHRAISQSGTALFRLFITSNPLKVAKKVAHLAGCNHNSTQIL-------VNCLRALSG 357

  Fly   612 ERLWAATPD---TWLHFPVDLPQPQEANASGSRHEWLVLDGDVVFEHPSDTWKREQANDKPVLVM 673
            .::...:..   ..|:|..|   |:|...|.|.    |:||.|:.:.|           ..:|..
Human   358 TKVMRVSNKMRFLQLNFQRD---PEEIIWSMSP----VVDGVVIPDDP-----------LVLLTQ 404

  Fly   674 GATAHEAHTEKLRELHANWTREEVRAYLENSQI--------------GALGLTDE----VIEKY- 719
            |..:...:...:..|..||....:..:..|.|.              ..|.:|.|    |:|:|
Human   405 GKVSSVPYLLGVNNLEFNWLLPYIMKFPLNRQAMRKETITKMLWSTRTLLNITKEQVPLVVEEYL 469

  Fly   720 -NASSY------ASLVSIISDIRSVCPLLTNA--RQQPSVPFY------------VVTQGEGPDQ 763
             |.:.:      ..::.|:.|...|...|..|  .:...:|.|            |..:.:|.|.
Human   470 DNVNEHDWKMLRNRMMDIVQDATFVYATLQTAHYHRDAGLPVYLYEFEHHARGIIVKPRTDGADH 534

  Fly   764 LATVDADVQAIL--GRYEPHTVEQRRFVSAMQQLFYYYVSHGTVQSFVQNRRVINVGQDAQPEED 826
                 .|....|  |.:.......:....::|.:.|:                .|..:...|.:.
Human   535 -----GDEMYFLFGGPFATGLSMGKEKALSLQMMKYW----------------ANFARTGNPNDG 578

  Fly   827 YLPCNYWISKDIVPRY 842
            .|||  |      |||
Human   579 NLPC--W------PRY 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_476798.1	PTZ00121	<3..>222	CDD:173412
		alpha/beta hydrolases	362..832	CDD:473884	136/589 (23%)
CES4A	XP_011521323.1	COesterase	50..613	CDD:395084	140/601 (23%)