DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrt and Ces1a

DIOPT Version :9

Sequence 1:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_001013786.2	Gene:	Ces1a / 244595	MGIID:	3648919	Length:	563	Species:	Mus musculus

Alignment Length:	587	Identity:	155/587 - (26%)
Similarity:	243/587 - (41%)	Gaps:	126/587 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 LFVLLLGVIGYVLTHETLTSPPLRE-------GRYIMAVTGCGPVEGVKEDGAFAFRGIPYAKPP 390
            ||.|.|..:...:....|:|||:.:       |:||.......||.        .|.|:|:||||
Mouse     3 LFALALASLNTCMALGHLSSPPVVDTLQGKVMGKYISLEGSAQPVA--------VFLGVPFAKPP 59

  Fly   391 VDRLRWKPAELIDDINMCWNDTLQTHNSSVVCTQRLGNGTTVGD--------------EDCLYLD 441
            :..||:.|.:..:    .|:....|.:...:|:|..|.|..:.|              ||||||:
Mouse    60 LGPLRFAPPQPAE----TWSSVKNTTSYPPMCSQITGVGPVLSDVFTNQLENVPLEYSEDCLYLN 120

  Fly   442 VVTP-HVRYNNPLPVVVLI-GAESLAGPSPGILRPSARYSRSHDVIFVRPNFRLGVFGFLALDAL 504
            :.:| .:...:.|||:|.: |...|:|.:...  .....|...:|:.|...:|||::|||:
Mouse   121 IYSPTDLTSKDRLPVMVWVHGGGLLSGGASTF--DGLALSTHENVVIVVIQYRLGIWGFLS---- 179

  Fly   505 TKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLYTR 569
            |.:.|  :.||:...|.:|.|.|::.||.:|||||.||||.|..||...|::||.|...|.|:.|
Mouse   180 TGDEH--SRGNWGHLDQVAALQWVQNNIANFGGDPSSVTLFGESAGGESVSVLVLSPLTKNLFQR 242

  Fly   570 AWASSGSAILPGKPLSESGKQNEQLMATLEC-----ADI-QCLREASSERLWAATPDTWLHFPVD 628
            |.:.||.|:.|......:.:..||:.....|     ||| .||||.:.|.|.|.|. ....|.:|
Mouse   243 AISESGVALTPCLFRETTRRAAEQVAIATGCVATTSADIVHCLREKTEEELLATTL-KMKFFALD 306

  Fly   629 -LPQPQEANASGSRHEWL--VLDGDVVFEHPSDTWKREQANDKPVLV--------------MGAT 676
             |..|:|:      :.:|  |:||.|:.:.|.:....:..|..|.:|              ||..
Mouse   307 LLGDPRES------YPFLTTVIDGVVLPKAPEEILAEKSFNTVPYIVGINKQEFGWFIPMMMGYP 365

  Fly   677 AHEAHTEKLRELHANWTREEVRAY-LENSQIGALGLTDEVIEKYNASSYAS------LVSIISDI 734
            ..|...::.......|     ::| |.|.   :..||....|||...|...      .:.::.|:
Mouse   366 LSEGKLDQKSATSLLW-----KSYPLTNI---SKELTPVATEKYLGGSDCPDKKKDLFLDMMGDV 422

  Fly   735 RSVCPLLTNAR--QQPSVPFYVVTQGEGPDQLA-----TVDAD----VQAILGR--YEPHTVEQR 786
            ....|.:..||  :....|.|:......|..::     ||.||    |.::.|.  .:....|:.
Mouse   423 LFAVPSVIVARYHRDAGAPTYMYEFKYHPSFVSDMRPKTVIADHGDEVYSVWGTPFLKEGASEEE 487

  Fly   787 RFVSAMQQLFY---------------YYVSHGTVQSFVQNRRVINVG---QDAQPEEDYLPCNYW 833
            ..:|.|...|:               ::..:|..:|::|      :|   |.||..:| ....:|
Mouse   488 INLSTMMMKFWGNFARNGNPNGEGLPHWPEYGEKESYLQ------IGATTQQAQRLKD-KEVAFW 545

  Fly   834 IS 835
            .|
Mouse   546 TS 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	142/546 (26%)
Ces1a	NP_001013786.2	Esterase_lipase	25..536	CDD:238191	143/551 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910