DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrt and Ces4a

DIOPT Version :9

Sequence 1:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_666325.2	Gene:	Ces4a / 234677	MGIID:	2384581	Length:	563	Species:	Mus musculus

Alignment Length:	605	Identity:	151/605 - (24%)
Similarity:	231/605 - (38%)	Gaps:	164/605 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 VFGILLFVLLL--GVIGYVLTHETL--TSPPLREGRYIMAVTGCGPVEGVKEDGAFAFRGIPYAK 388
            :.|:.|.:.|:  ..:|.:.|.|.|  |...:.:|:.:.  .|..|::        .|.|||::|
Mouse    11 ILGLSLTLCLVVQTALGALHTKEPLLITKHGILQGKQVH--VGDTPIQ--------VFLGIPFSK 65

  Fly   389 PPVDRLRWKPAELIDDINMCWNDTLQTHNSSVVCTQRLGNGTTVG--------------DEDCLY 439
            |||...|:.|.|    ..:.||...........|.|. ..|..:.              .|||||
Mouse    66 PPVGTRRFAPPE----PPLPWNGIRDATTYPPSCLQE-SWGQILSMYLNTRKQYKWLHFSEDCLY 125

  Fly   440 LDVVTPHVRYNNP-LPVVVLI-GAESLAGPSPGILRPSARYSRSHDVIFVRPNFRLGVFGFLALD 502
            |:|..|.:....| |||:|.. |...||| |......|...:|. .|:.|...:|||:.||.:
Mouse   126 LNVYAPVLAPGAPLLPVMVWFPGGAFLAG-SASTYEGSELAARG-KVVLVFLQYRLGILGFFS-- 186

  Fly   503 ALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLY 567
              |..:|  ..||:.|.|.||.|.|::.||..|||||.||||.|..|||..|:.|:.|...:||:
Mouse   187 --TGNSH--ARGNWGLLDQIAALRWVQENIEAFGGDPDSVTLFGQSAGAMSVSGLMVSPLAQGLF 247

  Fly   568 TRAWASSGSAILPG----KPLSESGKQNEQLMATLECAD-------IQCLREASSERLWAATPDT 621
            .:|.:.||:|:|..    .||:.:.|     :|.|...|       ::|||..|:|.
Mouse   248 HQAISQSGTAVLKAFITPDPLTSAKK-----IAHLAGCDHNSTKVMVECLRSLSAEE-------- 299

  Fly   622 WLHFPVDLPQPQEANASGSRHE------WL---VLDGDVVFEHPSDTWKREQANDKPVLV-MGAT 676
                 |.|...:.:....:.|:      |.   |:||.|..|.|.....|.|....|.|: :...
Mouse   300 -----VTLVSKRMSFFQANSHKDPKEIVWFLSPVVDGVVFPEDPVVLLTRGQVKPVPYLLGVNNA 359

  Fly   677 AHEAHTEKLRELHAN-------------W--------TREEV----RAYLENSQIGALGLTDEVI 716
            ..|.:...|.::..|             |        |:|:|    |.||           ::.|
Mouse   360 EFEWNLPFLMKIQLNQRMMNQTNINKILWSFNVLLNITKEQVPVVAREYL-----------NDAI 413

  Fly   717 EKYNASSYAS-LVSIISDIRSVCPLLTNAR--QQPSVPFY------------VVTQGEGPDQLAT 766
            ..::...:.: |:.:|.|...|...|..||  :....|.|            ::....|.|.
Mouse   414 SNHDWKMFRNRLIDLIGDATFVYATLQAARYHRDAGSPVYLYEFKHHASSGIIIKPYNGADH--- 475

  Fly   767 VDADVQAILGRYEPHTV-----EQRRFVSAMQQLFYYYVSHGTVQSFVQNRRVINVGQDAQPEED 826
             ..::..:.|  .|.:.     |::.|  ::|.:.|:                .|......|..:
Mouse   476 -GDELSYLFG--SPFSKGSSAGEEKEF--SLQMMKYW----------------ANFAHTGNPNGE 519

  Fly   827 YLPCNYWISKDIVPRYARVD 846
            .||  ||...|...:|.::|
Mouse   520 KLP--YWPRFDKDEKYLQLD 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	137/551 (25%)
Ces4a	NP_666325.2	COesterase	30..554	CDD:278561	147/586 (25%)
Ces4a	NP_666325.2	Aes	<128..>272	CDD:223730	58/151 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910