DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrt and Ces2e

DIOPT Version :9

Sequence 1:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_001157228.1	Gene:	Ces2e / 234673	MGIID:	2443170	Length:	559	Species:	Mus musculus

Alignment Length:	586	Identity:	147/586 - (25%)
Similarity:	236/586 - (40%)	Gaps:	143/586 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 IVFGILLFVLLLGVIGYVLTHETLTSPPLREGRYIMAVTGCGPVEG----VKED--GAFAFRGIP 385
            :..|:||.||      :|...:  ::.|:|.       |..|.|.|    ||:.  ....|.|||
Mouse    13 VACGVLLLVL------HVQGQD--SASPIRN-------THTGQVRGSLVHVKDTDIAVHTFLGIP 62

  Fly   386 YAKPPVDRLRWKPAELIDDINMCWNDTLQTHNSSVVCTQRLGNGTTVG----------------D 434
            :|||||..||:.|.|..:.    |:......:...:|.|   |...:|                .
Mouse    63 FAKPPVGPLRFAPPEAPEP----WSGVRDGTSHPNMCLQ---NDNLMGSEDLKMMNLILPPISMS 120

  Fly   435 EDCLYLDVVTP-HVRYNNPLPVVVLI--GAESLAGPSPGILRPSARYSRSHDVIFVRPNFRLGVF 496
            ||||||::..| |....:.|||:|.|  ||.::...|   :...:..:.:.||:.|...:||||.
Mouse   121 EDCLYLNIYVPAHAHEGSNLPVMVWIHGGALTVGMAS---MYDGSMLAATEDVVVVAIQYRLGVL 182

  Fly   497 GFLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQ 561
            ||.:    |.:.|  ..||:...|.:|.|.|::.|||||||:|..||:.|..||.|.|:..|.|.
Mouse   183 GFFS----TGDQH--AKGNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGTSVSSHVVSP 241

  Fly   562 KVKGLYTRAWASSGSAILPGKPLSESGKQNEQLMATLE-CADIQ------CLREASSERLWAATP 619
            ..:||:..|...||.|:||.. :|.|.:...:::|.|. ||.:.      |||..:...:.|...
Mouse   242 MSQGLFHGAIMESGVAVLPDL-ISSSSEMVHRIVANLSGCAAVNSETLMCCLRGKNEAEMLAINK 305

  Fly   620 DTWLHFPVDLPQPQEANASGSRHEWLVLDGDVVFEHPSDTWKREQANDKPVLVMGATAHE----- 679
                .|.: :|.              |:||:.:.:||.:....:..:..|.:: |....|
Mouse   306 ----VFKI-IPG--------------VVDGEFLPKHPQELMASKDFHPVPSII-GINNDEYGWIL 350

  Fly   680 ----AHTEKLRELHANWTREEVRAYLENSQIGAL---GLTDEVIEKYNASS------YASLVSII 731
                ...:|:.|:    ||:.:.|.|:::.:..:   ...|.::|:|...:      .|....:.
Mouse   351 PTIMDPAQKIEEI----TRKTLPAVLKSTALKMMLPPECGDLLMEEYMGDTEDPETLQAQFREMK 411

  Fly   732 SDIRSVCPLLTNAR-QQPSVPFYVVTQGEGPD-----QLATVDAD----VQAILGRYE------P 780
            .|...|.|.|..|. |:...|.|.......|.     :...|.||    :..:.| |:      |
Mouse   412 GDFMFVIPALQVAHFQRSHAPVYFYEFQHRPSFFKDFRPPYVKADHGDEIFLVFG-YQFGNIKLP 475

  Fly   781 HTVEQRRFVSAMQQLFYYYVSHGTVQSFVQNRRVINVGQDAQPEEDYLPCNYWISKDIVPRYARV 845
            :|.|:.:....:.:.:..:..||                  .|..:.||  ||...|...:|.::
Mouse   476 YTEEEEQLSRRIMKYWANFARHG------------------NPNSEGLP--YWPVMDHDEQYLQL 520

  Fly   846 D 846
            |
Mouse   521 D 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	134/535 (25%)
Ces2e	NP_001157228.1	COesterase	30..538	CDD:278561	141/561 (25%)
Ces2e	NP_001157228.1	Aes	<128..>231	CDD:223730	39/111 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910