Protein Alignment Nrt and cest-7

DIOPT Version :10

• Sequence 1: NP_476798.1
• Gene: Nrt / 39873
• FlyBaseID: FBgn0004108
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_001257187.1
• Gene: cest-7 / 182819
• WormBaseID: WBGene00007693
• Length: 606
• Species: Caenorhabditis elegans
• Alignment Length: 564
• Identity: 134/564 - (23%)
• Similarity: 209/564 - (37%)
• Gaps: 154/564 - (27%)

  Fly   365 TGCGPVEGV-----KEDGAFAFRGIPYAKPPVDRLRWKPAELIDDINMCWNDTLQTHNSSVVCTQ 424
            |..|.|.|:     |.:..:.|:|||:||||:..||:   .|.::.| .||..|.....|..|
 Worm    42 TNYGKVRGITDFSDKRNHKYIFKGIPFAKPPLGLLRF---ALPEEPN-TWNGVLDGSKYSAAC-- 100

  Fly   425 RLGNGTTVG------DEDCLYLDVVTPHVRYNNPLPVVVLI--GAESLAG----PSPGILRPSAR 477
             |.|.:...      .|||||:::.|......:..||:|..  |:.:|..    |...||.   |
 Worm   101 -LSNSSLASAQQENISEDCLYINIFTSEYCLAHKCPVLVYYHGGSFNLDSATMFPDKFILE---R 161

  Fly   478 YSRSHDVIFVRPNFRLGVFG--FLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQ 540
            |..| .::|..|.:||||||  :|....:       ...|..:.|.|..||::..||..|||||.
 Worm   162 YVDS-GIVFAIPAYRLGVFGQFYLGEQGI-------VPANLLIHDCIRSLNFVHDNIASFGGDPN 218

  Fly   541 SVTLLGHRAGATLVTLLVNSQKV---KGLYTRAWASSGSAILPGKPLSESGKQNEQLMATLECAD 602
            .|||:||.:|..||..:..|.::   |.|:.:....|.        :...|.::.|:..:.|.|.
 Worm   219 YVTLMGHSSGGQLVNAMGFSNQIDPEKKLFQQFIVLSS--------IGMYGFEDLQIGNSYEIAR 275

  Fly   603 ------------IQCLREASSERL---WAATPDTWLHF--------P-VDLPQ-----PQEANAS 638
                        :.|:|...:.:|   .....|..|.|        | :|:.|     .:...|.
 Worm   276 RHNCTSENSQEIVDCMRNIDALQLLQTQTVMDDVDLLFFKAIIRAPPLMDVKQKLSEFKENVTAR 340

  Fly   639 G-----SRHEWLVL---DGDVV------FEHPSDT---WKREQANDKP---------VLVMGATA 677
            .     :.:|:.:.   ||..:      ||:|.||   ::.:..|..|         |.|..||.
 Worm   341 NMLCGVTDNEFTIFKYPDGYYISATFLDFENPVDTVNVYRNKFTNITPTFVNSDSSAVFVSAATY 405

  Fly   678 HEAHT------------EKLRELHANWTREEVRAYLENSQIGALGLTDEVI-------------- 716
            .||.|            :|...:|....:..:..:.|.:....:.:.|...
 Worm   406 SEALTNAGGNVYLFESRQKPFSMHVTDMQYFIGIHREKNHTTDMDILDSFYSKLLVNFTKFGSPS 470

  Fly   717 ---EKYNASSYASLVSIISDIRSVCPLLTNARQQPSVPFYVVT-------------QGE-----G 760
               |||:.|....:...|...:.:.|.:.|...:..|.|:::.             .||     |
 Worm   471 PNWEKYDPSKMNFMAMEIDTEQGIEPKMENGFHEELVNFWLINMMQIDRNIIEMKLNGEYNSFDG 535

  Fly   761 PDQLATVDADVQAILG-RYEP--HTVEQRRFVSAMQQLFYYYVS 801
            ..||.|....|...|. .|.|  ...|....:|.:.| :::|||
 Worm   536 RAQLTTKHIGVPTSLPIIYAPAVSDPENLELISVLNQ-WWFYVS 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_476798.1	PTZ00121	<3..>222	CDD:173412
		alpha/beta hydrolases	362..832	CDD:473884	134/564 (24%)
cest-7	NP_001257187.1	alpha/beta hydrolases	38..510	CDD:473884	117/493 (24%)