Protein Alignment Nrt and cest-3

DIOPT Version :10

• Sequence 1: NP_476798.1
• Gene: Nrt / 39873
• FlyBaseID: FBgn0004108
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_510042.2
• Gene: cest-3 / 181385
• WormBaseID: WBGene00008451
• Length: 588
• Species: Caenorhabditis elegans
• Alignment Length: 579
• Identity: 132/579 - (22%)
• Similarity: 204/579 - (35%)
• Gaps: 169/579 - (29%)

  Fly   338 LGVIGYVLTHETLTSPPLREGRYIMAVTGCGPVEG--VKEDGAFAFRGIPYAKPPVDRLRWKPAE 400
            |.|:.|:|...||..    .|:.|::.| .|.:||  |..| ...|:.:|:||||:.:||:...|
 Worm     4 LHVLYYILFVFTLNG----SGQRIISTT-YGKLEGKTVNVD-QHMFKNVPFAKPPLGKLRFSLPE 62

  Fly   401 LIDDINMCWNDTLQTHNSSVVC----TQRLGNGTTVGDEDCLYLDVVTPH--VRYNNPLPVVVLI 459
            ..:.    |.:.......|..|    :.|..:......||||||:|.|..  ::..|...||...
 Worm    63 WTNP----WKNIRNATEYSPSCFSNSSMRTDSNFFPMSEDCLYLNVFTNEYCLKSKNCSTVVYYH 123

  Fly   460 GAESLAGPSPGILRPSA----------RYSRSHDVIFVRPNFRLGVFGFLALDA--LTKEAHPPT 512
            |.        ||...||          ||.: .:|:|:.|.:|||:||.|...:  |..:
 Worm   124 GG--------GINMDSAVQFNDTFILERYVK-ENVVFIIPAYRLGIFGLLYFGSNNLVPQ----- 174

  Fly   513 SGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKV---KGLYTRAWASS 574
              |.|:.|....|.:|...|.:|||....:.|:||.|||.:..:...|:.:   ..|..|....|
 Worm   175 --NLAIHDCELALRFIHQEISNFGGHKDDINLMGHSAGAHISLIFGFSRHIDPDHKLINRIIVLS 237

  Fly   575 GSAILPGKPLSESGKQNEQLMATLECAD-------------------IQCLREASSERLWAATPD 620
            .   :|...:.|        :....|.|                   ::|||:..:..|.:.
 Worm   238 P---VPSYDMPE--------LLIKNCYDFAERVGCYKRNVTARDTEIVKCLRKKDARGLMSM--- 288

  Fly   621 TWLHFPVDLPQPQEANASGSRHEWLVLDGD-VVFEHPSDTWKREQANDKPVLVMGATAHEAHTEK 684
                        |....:...:.|..|.|: .::...|....:|.|..:.:|: |.|..|...::
 Worm   289 ------------QRLMENDRLYFWNFLAGEPFMYRDESIADFKEYAVKRDMLI-GNTVDEVKWKR 340

  Fly   685 LRELHANWTREEVRAYLENSQIGALGLTD-----EVIEKYN--------ASSYASLV-SIISDIR 735
            |::              ||..| |....|     ||..|:|        .|:|.|.. .|.....
 Worm   341 LKK--------------ENPAI-AGSFMDWENPYEVAHKFNFYHDSAPVNSTYESFTQGIFVSTA 390

  Fly   736 SVCPLLTNA---------RQQPS-----VPFYVVTQGEGPDQLATVDADVQAILGRYEPHTVEQR 786
            :......||         .||||     :.::|.|..|   ...|.|.|:....  |....|...
 Worm   391 TYAEAQANAGGTVYLFQSNQQPSSHVSDMQYFVGTHRE---DYHTSDMDIMDTF--YSKMIVNFT 450

  Fly   787 RFVS--------AMQQLFYYYVSHGTVQSFVQNRRVINVGQDAQP--EEDY--LPCNYW 833
            :|.|        ...::.||.:.             :|..:...|  |||:  ...|:|
 Worm   451 KFGSPSPVWEPLVPSRMNYYALE-------------VNTEKGIWPRMEEDFHESDVNFW 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_476798.1	PTZ00121	<3..>222	CDD:173412
		alpha/beta hydrolases	362..832	CDD:473884	122/552 (22%)
cest-3	NP_510042.2	alpha/beta hydrolases	21..496	CDD:473884	124/556 (22%)