DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nrt and cest-12

DIOPT Version :9

Sequence 1:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_499576.4	Gene:	cest-12 / 176642	WormBaseID:	WBGene00013540	Length:	850	Species:	Caenorhabditis elegans

Alignment Length:	526	Identity:	113/526 - (21%)
Similarity:	189/526 - (35%)	Gaps:	94/526 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 LLFVLLLGVIGYVLTHETLTSPPLREGRYIMAVTGCGPVEG-----------VKEDGAFAFRGIP 385
            |||:.|......|...:.......::..|:......|.|:|           :....|.||.|||
Worm     6 LLFLTLFSAFSNVSNAQYQNQNQNQQSNYVTVSCSQGSVQGRQVNLGNDQSQLYSGQANAFTGIP 70

  Fly   386 YAKPPVDRLRWKPAELIDDINMCWNDTLQTHNSSVVCTQRLGNGTTVGDEDCLYLDVVTPHVRYN 450
            |.:.||..||.:|.:.::..|...:|.......   |.|....|.|  :||||||:|.||.....
Worm    71 YCQAPVGNLRLQPPQPLNQFNTTLHDATYFRPK---CPQLNAGGPT--NEDCLYLNVYTPQAGNT 130

  Fly   451 NP-LPVVVLI-GAESLA------GPSPGILRPSARYSRSHDVIFVRPNFRLGVFGFLALDALTKE 507
            |. |.|:||| |:...:      ....||:....:    ..::.|...:|:|..||......:.:
Worm   131 NANLSVLVLIDGSNGFSNGGCDQNQEKGIISNLVQ----RQIVVVTMQYRIGALGFFTTYTNSVQ 191

  Fly   508 AHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLYTRAWA 572
            :      |..:.|.:..:.|||..||:|||:|..:|:.|...||..|:....|...:.|:.:|..
Worm   192 S------NLGMLDQVQAMRWIKTEIVNFGGNPNQITVAGQDDGACAVSAHCLSPMSQNLFNQAIV 250

  Fly   573 SSGSAI-----LPGKPLSESGKQNEQLMATLECADIQCLREASSERLWAATPDTWLHFPVDLPQP 632
            .|||..     .|..|      .|.|:..|..    :.:.:.|:.....|.......:     ||
Worm   251 QSGSVYSCYNPTPAVP------TNPQVQVTTP----RPMYDQSNTGYGNAGYQNNYGY-----QP 300

  Fly   633 QEANASGSRHEWLVLDGDVVFEHPSDTWKREQANDKPVLVMGATAHEAHTEKLRELHANWTREEV 697
            |...::.|.:     ..:..::.||....:...|..|     ...:...|:.::....|:|.:
Worm   301 QPITSTSSYN-----SANAQYDDPSQQLAQTLCNISP-----DQWNNGQTQNIQNCMKNYTVD-- 353

  Fly   698 RAYLENSQIGALGLTDEVIEKYNASSYASLVSIISDIRSVCPLLTNARQQPSV--PFYVVTQGEG 760
              :..|.|.|....|..::.  :.|.....:..::..|...|::....|....  .|.::..|:|
Worm   354 --FFVNQQPGGPNATWMIVR--DTSFLPGSIDSLTTRRPNIPIIIGTVQDEDADYAFKLINTGKG 414

  Fly   761 PDQLATVDADVQAILGRYEPHTVEQRRFVSAMQQLFYYYVSHGTVQSFVQNRRVINVG----QDA 821
            .|                 |:.::...|..|.:... .......|.:.:.|...:|.|    |.|
Worm   415 SD-----------------PNNLDDWIFDFARKNKL-NQTQANQVSNIISNNYGVNTGALGQQGA 461

  Fly   822 QPEEDY 827
            |....|
Worm   462 QVNSQY 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	107/496 (22%)
cest-12	NP_499576.4	Abhydrolase	37..>400	CDD:389770	92/408 (23%)
cest-12	NP_499576.4	Abhydrolase	<678..774	CDD:389770
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000