Protein Alignment Nrt and Ces1e

DIOPT Version :10

• Sequence 1: NP_476798.1
• Gene: Nrt / 39873
• FlyBaseID: FBgn0004108
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_598421.1
• Gene: Ces1e / 13897
• MGIID: 95432
• Length: 562
• Species: Mus musculus
• Alignment Length: 597
• Identity: 150/597 - (25%)
• Similarity: 237/597 - (39%)
• Gaps: 149/597 - (24%)

  Fly   325 ALIVFGILLFVLLLGVIGYVLTHETLTSPPLRE-------GRYIMAVTGCGPVEGVKEDGAFAFR 382
            |||:..:..|....|       |.  :|||:.:       |:||       .:||..:..| .|.
Mouse     5 ALILVSLAAFTAGAG-------HP--SSPPMVDTVQGKVLGKYI-------SLEGFTQPVA-VFL 52

  Fly   383 GIPYAKPPVDRLRWKPAELIDDINMCWNDTLQTHNSSVVCTQRLGNGTTVGD------------- 434
            |:|:||||:..||:.|.:..:.    |:......:...:|.|....|..|.|
Mouse    53 GVPFAKPPLGSLRFAPPQPAEP----WSSVKNATSYPPMCFQDPVTGQIVNDLLTNRKEKIPLQF 113

  Fly   435 -EDCLYLDVVTP-HVRYNNPLPVVVLI--GAESLAGPS--PGILRPSARYSRSHDVIFVRPNFRL 493
             ||||||::.|| .:..::.|||:|.|  |...|.|.|  .|::     .|...:|:.|...:||
Mouse   114 SEDCLYLNIYTPADLTKSDRLPVMVWIHGGGLVLGGASTYDGLV-----LSTHENVVVVVIQYRL 173

  Fly   494 GVFGFLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLV 558
            |::||.:    |.:.|  :.||:...|.:|.|:|::.||..|||||.|||:.|..||...|::||
Mouse   174 GIWGFFS----TGDEH--SRGNWGHLDQVAALHWVQDNIAKFGGDPGSVTIFGESAGGESVSVLV 232

  Fly   559 NSQKVKGLYTRAWASSGSAILPG------KPLSE-----SGKQNEQLMATLECADIQCLREASSE 612
            .|...|.|:.||.:.||.|:..|      :||:|     ||.:|     |...|.:.|||:.:.|
Mouse   233 LSPLAKNLFQRAISESGVALTAGLVKKNTRPLAEKIAVISGCKN-----TTSAAMVHCLRQKTEE 292

  Fly   613 RLWAATPDTWLHFPVDLPQPQEANASGSRHEWL--VLDGDVVFEHPSDTWKREQANDKPVLVMGA 675
            .|...|....| |.:||     ...|...|.::  ||||.::.:.|.:....:..|..|.:| |.
Mouse   293 ELLGTTLKLNL-FKLDL-----HGDSRQSHPFVPTVLDGVLLPKMPEEILAEKNFNTVPYIV-GI 350

  Fly   676 TAHEAHTEKLRELHANWTREEVRAY----LENSQIGALGLTDE--------------VIEK---- 718
            ...|          ..|....:..|    ::..|:.|:.|..:              .|||
Mouse   351 NKQE----------FGWILPTMMNYPPSDVKLDQMTAMSLLKKSSFLLNLPEDAIAVAIEKYLRD 405

  Fly   719 --YNASSYASLVSIISDIRSVCP--LLTNARQQPSVPFYVVTQGEGPDQLATVDAD--------- 770
              |...:...|:.:|.|:....|  :::...:....|.|:......|...:.:..|
Mouse   406 KDYTGRNKDQLLELIGDVVFGVPSVIVSRGHRDAGAPTYMYEFQYSPSFSSEMKPDTVVGDHGDE 470

  Fly   771 VQAILGR--YEPHTVEQRRFVSAMQQLFYYYVSHGTVQSFVQNRRVINVGQDAQPEEDYLPCNYW 833
            :.::.|.  ....|.|:...:|.|...|:                 .|..::..|....||  :|
Mouse   471 IYSVFGAPILRGGTSEEEINLSKMMMKFW-----------------ANFARNGNPNGQGLP--HW 516

  Fly   834 ISKDIVPRYARV 845
            ...|....|.::
Mouse   517 PEYDQKEGYLQI 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_476798.1	PTZ00121	<3..>222	CDD:173412
		alpha/beta hydrolases	362..832	CDD:473884	135/538 (25%)
Ces1e	NP_598421.1	COesterase	23..546	CDD:395084	144/570 (25%)
		Prevents secretion from ER. /evidence=ECO:0000255	559..562