DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nrt and ache

DIOPT Version :9

Sequence 1:	NP_001189121.1	Gene:	Nrt / 39873	FlyBaseID:	FBgn0004108	Length:	846	Species:	Drosophila melanogaster
Sequence 2:	NP_571921.1	Gene:	ache / 114549	ZFINID:	ZDB-GENE-010906-1	Length:	634	Species:	Danio rerio

Alignment Length:	439	Identity:	118/439 - (26%)
Similarity:	175/439 - (39%)	Gaps:	97/439 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 IMAVTGCGPVEGVK-----EDGAFAFRGIPYAKPPVDRLRWKPAELIDDINMCWNDTLQTHNSSV 420
            ::..|..|.|:|.:     .....||.|||||:||:.:.|:|.||    ....||:..:....|.
Zfish    29 LVVATRLGRVQGTRLPVPDRSHVIAFLGIPYAEPPIGKRRFKRAE----PKKPWNNVFEAKEFSN 89

  Fly   421 VCTQ------------RLGNGTTVGDEDCLYLDV-VTPHVRYNNPLPVVVLIGAESLAGPSPGIL 472
            .|.|            .:.|...|..||||||:| |.|..|..|...:|.:.|....:|.|...:
Zfish    90 ACYQFVDTSYPGFPGIEMWNPNRVMSEDCLYLNVWVPPTPRPQNLTVMVWIYGGGFYSGSSSLDV 154

  Fly   473 RPSARYSRSHDVIFVRPNFRLGVFGFLALDALTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGG 537
            ......:.:..|:.|..|:|:|.||||||:..:     ...||..|.|....|.|::.||..|||
Zfish   155 YDGRYLAYTEKVVVVSMNYRVGAFGFLALNGSS-----DAPGNVGLYDQRLALQWVQENIHFFGG 214

  Fly   538 DPQSVTLLGHRAGATLVTLLVNSQKVKGLYTRAWASSGSAILPGKP-----LSESGKQNEQLMAT 597
            :|:.||:.|..|||..|.:.|.|...:.|:|||...||   :|..|     ..|:.::..:|...
Zfish   215 NPKQVTIFGESAGAASVGMHVLSPDSRPLFTRAILQSG---VPNTPWATVTFDEARRRTTKLGKL 276

  Fly   598 LECA---D---IQCLREASSERL----WAATPDTW--------------LHFPVDLPQPQEANAS 638
            :.|.   |   |.|||....:.|    |...|  |              :.||   ..|....:|
Zfish   277 VGCTWGNDTELIDCLRNKHPQELIDQEWQVLP--WSSLFRFSFVPVVDGVFFP---DTPDAMISS 336

  Fly   639 GSRHEWLVLDGDVVFEHPSDTWKREQANDKPVLVMGATAHEAHTEKLRELHANWTREEVRAYLEN 703
            |:            |::........|......|:.||.......|.|      .:||:   :||:
Zfish   337 GN------------FKYTQILLGVNQDEGSYFLLYGAPGFSKDNESL------ISRED---FLES 380

  Fly   704 SQIGA-----LGL-------TDEVIEKYNASSYASLVSIISDIRSVCPL 740
            .::|.     :||       ||.:.|.....:..::..|:.|...:|||
Zfish   381 VKMGVPHANDIGLEAVILQYTDWMDENNGQKNRDAMDDIVGDQNVICPL 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_001189121.1	Abhydrolase	362..832	CDD:304388	118/438 (27%)
ache	NP_571921.1	COesterase	23..583	CDD:278561	118/439 (27%)
ache	NP_571921.1	AChE_tetra	598..631	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000