Protein Alignment Nrt and Ache

DIOPT Version :10

• Sequence 1: NP_476798.1
• Gene: Nrt / 39873
• FlyBaseID: FBgn0004108
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: XP_036020624.1
• Gene: Ache / 11423
• MGIID: 87876
• Length: 616
• Species: Mus musculus
• Alignment Length: 582
• Identity: 154/582 - (26%)
• Similarity: 210/582 - (36%)
• Gaps: 197/582 - (33%)

  Fly   332 LLFVLLLGVIGYVLTHETLTSPPLREGRYIMAVTGCGPVEGV--KEDG--AFAFRGIPYAKPPVD 392
            ||| |||.::|.....|....|.|     ::.|.| |.:.|:  |..|  ..||.|||:|:|||.
Mouse    17 LLF-LLLSLLGGGARAEGREDPQL-----LVRVRG-GQLRGIRLKAPGGPVSAFLGIPFAEPPVG 74

  Fly   393 RLRWKPAELIDDINMCWNDTLQTHNSSVVCTQRLG------NGTTVGD------EDCLYLDVVTP 445
            ..|:.|.|    ....|:..|.......||.|.:.      .||.:.:      ||||||:|.||
Mouse    75 SRRFMPPE----PKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTP 135

  Fly   446 HVRYNNPLPVVVLI-------GAESLAGPSPGILRPSARYSRSHDVIFVRPNFRLGVFGFLALDA 503
            :.|..:|.||::.|       ||.||.......|      ::....:.|..|:|:|.||||||..
Mouse   136 YPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFL------AQVEGAVLVSMNYRVGTFGFLALPG 194

  Fly   504 LTKEAHPPTSGNYALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLYT 568
             ::||    .||..|.|....|.|::.||..|||||.||||.|..|||..|.:.:.|...:.|:.
Mouse   195 -SREA----PGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFH 254

  Fly   569 RA----------WA--SSGS--------AILPGKPLSESGKQNEQLMATLECADIQCLREASSER 613
            ||          ||  |:|.        |.|.|.|...:|..:.:|:|        |||...::.
Mouse   255 RAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTELIA--------CLRTRPAQD 311

  Fly   614 LWAATPDTWLHFPVDLPQPQEANASGSRHEWLVL--------------DGDVVFEHPSDTWKREQ 664
            |            ||             |||.||              |||.:.:.|........
Mouse   312 L------------VD-------------HEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGD 351

  Fly   665 ANDKPV------------LVMGATAHEAHTEKLRELHANWTREEVRA-YLENSQIG--------- 707
            ..|..|            ||.|........|.|..          || :|...:||
Mouse   352 FQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLIS----------RAQFLAGVRIGVPQASDLAA 406

  Fly   708 ---ALGLTDEVIEKYNASSYASLVSIISDIRSVCPLLTNARQQPSVPFYVVTQGEGPDQLATVDA 769
               .|..||.:..:.......::.:::.|...|||               |.|..|  :||...|
Mouse   407 EAVVLHYTDWLHPEDPTHLRDAMSAVVGDHNVVCP---------------VAQLAG--RLAAQGA 454

  Fly   770 DVQAILGRYE------------PH------------------TVEQRRFVSAMQQLFYYYVS 801
            .|.|.:..:.            ||                  |.|:|.|.   |:|..|:.:
Mouse   455 RVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTTEERIFA---QRLMKYWTN 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_476798.1	PTZ00121	<3..>222	CDD:173412
		alpha/beta hydrolases	362..832	CDD:473884	144/552 (26%)
Ache	XP_036020624.1	COesterase	37..563	CDD:395084	146/561 (26%)