Protein Alignment Nrt and Ces1d

DIOPT Version :10

• Sequence 1: NP_476798.1
• Gene: Nrt / 39873
• FlyBaseID: FBgn0004108
• Length: 846
• Species: Drosophila melanogaster
• Sequence 2: NP_444430.2
• Gene: Ces1d / 104158
• MGIID: 2148202
• Length: 565
• Species: Mus musculus
• Alignment Length: 581
• Identity: 140/581 - (24%)
• Similarity: 235/581 - (40%)
• Gaps: 160/581 - (27%)

  Fly   351 TSPPLRE-------GRYIMAVTGCGPVEGVKEDGAFAFRGIPYAKPPVDRLRWKPAELIDDINMC 408
            :|||:..       |:|:       .:||..:..| .|.|:|:||||:..||:.|.:..:.
Mouse    21 SSPPVVNTVKGKVLGKYV-------NLEGFTQPVA-VFLGVPFAKPPLGSLRFAPPQPAEP---- 73

  Fly   409 WNDTLQTHNSSVVCTQRLGNGTTVGD--------------EDCLYLDVVTP-HVRYNNPLPVVVL 458
            |:....|.:...:|:|....|..:.:              ||||||::.|| .:..|:.|||:|.
Mouse    74 WSFVKNTTSYPPMCSQDAVGGQVLSELFTNRKENIPLQFSEDCLYLNIYTPADLTKNSRLPVMVW 138

  Fly   459 I--------GAESLAGPSPGILRPSARYSRSHDVIFVRPNFRLGVFGFLALDALTKEAHPPTSGN 515
            |        ||.:..|         ...|...:|:.|...:|||::||.:    |.:.|  :.||
Mouse   139 IHGGGLVVGGASTYDG---------LALSAHENVVVVTIQYRLGIWGFFS----TGDEH--SRGN 188

  Fly   516 YALTDIIAVLNWIKLNIVHFGGDPQSVTLLGHRAGATLVTLLVNSQKVKGLYTRAWASSGSAILP 580
            :...|.:|.|.|::.||.:|||:|.|||:.|..||...|::||.|...|.|:.||.:.||.::..
Mouse   189 WGHLDQVAALRWVQDNIANFGGNPGSVTIFGESAGGFSVSVLVLSPLAKNLFHRAISESGVSLTA 253

  Fly   581 G------KPLSESGKQNEQLMATLE-CAD------IQCLREASSERLWAATPDTWLHFPVD-LPQ 631
            .      ||::       .|:|||. |..      :.|||:.:.:.|...:....| |.:| |..
Mouse   254 ALITTDVKPIA-------GLVATLSGCKTTTSAVMVHCLRQKTEDELLETSLKLNL-FKLDLLGN 310

  Fly   632 PQEANASGSRHEWL--VLDGDVVFEHPSDTWKREQANDKPVLV--------------MGATAHEA 680
            |:|:      :.:|  |:||.|:.:.|.:....:..:..|.:|              ||....|.
Mouse   311 PKES------YPFLPTVIDGVVLPKAPEEILAEKSFSTVPYIVGINKQEFGWIIPTLMGYPLAEG 369

  Fly   681 HTEKLRELHAN---WTREEVRAYLENS-QIGA---LGLTDEVIEKYNASSYASLVSIISDIRSVC 738
               ||.:..||   |.........||. .:.|   ||.||::.:|.:.     ...:::|:..
Mouse   370 ---KLDQKTANSLLWKSYPTLKISENMIPVVAEKYLGGTDDLTKKKDL-----FQDLMADVVF-- 424

  Fly   739 PLLTNARQQPSVPFYVVTQGEGPDQLATVDADVQAILGRYEPHTVEQRRFVSAMQ---------- 793
                      .||..:|::...       ||.....:..:|    .:..|||||:
Mouse   425 ----------GVPSVIVSRSHR-------DAGASTYMYEFE----YRPSFVSAMRPKAVIGDHGD 468

  Fly   794 QLFYY----YVSHGTVQSFVQNRRVI-----NVGQDAQPEEDYLPCNYWISKDIVPRYARV 845
            ::|..    ::..|..:......:::     |..::..|....||  :|...|....|.::
Mouse   469 EIFSVFGSPFLKDGASEEETNLSKMVMKFWANFARNGNPNGGGLP--HWPEYDQKEGYLKI 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nrt	NP_476798.1	PTZ00121	<3..>222	CDD:173412
		alpha/beta hydrolases	362..832	CDD:473884	132/548 (24%)
Ces1d	NP_444430.2	COesterase	22..545	CDD:395084	140/580 (24%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565