DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9701 and Kl

DIOPT Version :9

Sequence 1:	NP_648918.1	Gene:	CG9701 / 39872	FlyBaseID:	FBgn0036659	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_112626.1	Gene:	Kl / 83504	RGDID:	620396	Length:	1014	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	196/548 - (35%)
Similarity:	271/548 - (49%)	Gaps:	88/548 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMQIILPLFVLTASCLGS---------------PVSQTR-----RFPNDFLWGVGSSSYQIEGGW 45
            ::.:.|.|..|.|.||.:               ||.:..     .||:.|||.|||::||.||||
  Rat    18 LLSLHLLLLTLRARCLSAEPGQGAQTWARFARPPVPEASGLLHDTFPDGFLWAVGSAAYQTEGGW 82

  Fly    46 NADDKGESIWDFLTHTHPEKIVD----------------RSNGDVSADSYHQWKRDVQMVKELHV 94
            ....||.||||..|| ||..|.:                .|.|||::|||:...||.:.::||.|
  Rat    83 RQHGKGASIWDTFTH-HPRAIPEDSPIVMAPSGAPLPPLPSTGDVASDSYNNVYRDTEGLRELGV 146

  Fly    95 GTYRFSLSWPRIMPGGYMNHVSTAGIKYYSNLIDELLRYNITPMVTIYHWELPQKLQE-LGGWTN 158
            ..||||:||.|::|.|.....:..|::||..|::.|....:.|:||:|||:|||:||: .|||.|
  Rat   147 THYRFSISWARVLPNGTAGTPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDTYGGWAN 211

  Fly   159 PEIIPLFKDYARLVLEMYGDRVKIWTTVNEPWHVCEHGYGVDYMAPSYNYPGIPAYLCGHNLLKA 223
            ..:...|:|||.|....:|.:||.|.|::.|:.|..|||....:||.........||..||||.|
  Rat   212 RALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGVRGSSRLGYLVAHNLLLA 276

  Fly   224 HAEVVHMYRELFQPRQGGRMGITLDTSWPEPRDPNSAEDREASERAMQFYVGWFGHPIFSKHGNY 288
            ||:|..:|...|:|.||||:.|.|.:.|..||.......||. ::::.|.:|||..|||. .|:|
  Rat   277 HAKVWRLYNTSFRPTQGGRVSIALGSHWITPRRMTDYHIREC-QKSLDFVLGWFAKPIFI-DGDY 339

  Fly   289 PKVMIERIRNLSKEQGFGARSRLPEFTTEEIHRIRGTSDFFGINSYTSNLVTSNGHNNTGKFPVP 353
            ||.|   ..|||        |.||:||..|...||||:|||.:         |.|...:.:...|
  Rat   340 PKSM---KNNLS--------SLLPDFTESEKRFIRGTADFFAL---------SFGPTLSFQLLDP 384

  Fly   354 SFNHDMGVVESQEGVDWPGSGSVWLKVYPKGMYNLLMWIHREYNAPEIIVTENG--VSDRGGLED 416
            |..                    :.::....:..||.||..|||.|:|.:.|||  ||.....:|
  Rat   385 SMK--------------------FRQLESPSLRQLLSWIDLEYNHPQIFIVENGWFVSGTTRRDD 429

  Fly   417 YARVDYYNLYLSAVLDAME-DGANISGYIAWSLMDSYEWKAGFSEKFGLYHVDFNSPQRTRTPKI 480
            ...:.|...::...|.|:. ||.::.||.||||||.:||..|:|.:.||::|||.|..:...||.
  Rat   430 AKYMYYLKKFIMESLKAIRLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKELLPKS 494

  Fly   481 SARVFAQLCKTNTIDWSYRPKLDEEQQL 508
            ||..:.:|.:.|..     |.|.|.|.|
  Rat   495 SALFYQKLIENNGF-----PPLPENQPL 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9701	NP_648918.1	Glyco_hydro_1	22..492	CDD:304882	182/494 (37%)
Kl	NP_112626.1	Glyco_hydro_1	59..508	CDD:304882	183/491 (37%)
		Glycosyl hydrolase-1 1	59..508		183/491 (37%)
		Glycosyl hydrolase-1 2	517..955		1/1 (100%)
		Glyco_hydro_1	519..955	CDD:304882
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350787
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2723
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D257823at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44538
orthoMCL	1	0.900	-	-		OOG6_100193
Panther	1	1.100	-	-	O	PTHR10353
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.750