DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9701 and gba3

DIOPT Version :9

Sequence 1:	NP_648918.1	Gene:	CG9701 / 39872	FlyBaseID:	FBgn0036659	Length:	541	Species:	Drosophila melanogaster
Sequence 2:	NP_001018529.1	Gene:	gba3 / 553722	ZFINID:	ZDB-GENE-050522-351	Length:	475	Species:	Danio rerio

Alignment Length:	469	Identity:	196/469 - (41%)
Similarity:	280/469 - (59%)	Gaps:	21/469 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 FPNDFLWGVGSSSYQIEGGWNADDKGESIWDFLTHTHPEKIVDRSNGDVSADSYHQWKRDVQMVK 90
            ||.||.||..:::||||||||.|.:|.||||...| ...::...:.|||:.:||..|:.|::.::
Zfish     9 FPKDFAWGAATAAYQIEGGWNMDGRGPSIWDTFCH-EGGRVFGDNTGDVACNSYQLWEEDLKCIQ 72

  Fly    91 ELHVGTYRFSLSWPRIMPGGYMNHVSTAGIKYYSNLIDELLRYNITPMVTIYHWELPQKLQELGG 155
            :|.:..||.|:||.||:|.|..||::..|::||:.:||.|:...:|||:|::|.:|||.||:.||
Zfish    73 QLGLSHYRLSVSWSRILPNGTTNHINPKGVEYYNKVIDSLIASGVTPMITLWHMDLPQALQDCGG 137

  Fly   156 WTNPEIIPLFKDYARLVLEMYGDRVKIWTTVNEPWHVCEHGYGVDYMAPSYNYPGIPAYLCGHNL 220
            |.:.||..:|:.||....:.:|||||:|.|:|||:.....||.....||....||:..|:.|||:
Zfish   138 WCSAEIADIFESYASFCFKNFGDRVKLWITLNEPYVCAMLGYEDGIFAPGIKDPGLSVYVAGHNM 202

  Fly   221 LKAHAEVVHMYRELFQPRQGGRMGITLDTSWPEPRDPNSAEDREASERAMQFYVGWFGHPIFSKH 285
            |:|||:..|.|...|:|.|||::.:.|   :.:..:|.:|:|..|:||..:|.:.||..|:|..
Zfish   203 LRAHAKAWHAYNTHFRPSQGGQVSLAL---YSDRAEPLTAKDAAATERYKEFTLDWFACPVFCT- 263

  Fly   286 GNYPKVMIERIRNLSKEQGFGARSRLPEFTTEEIHRIRGTSDFFGINSYTSNLVTSNGHNNTGKF 350
            |:||:.|..||.|.|.|.|:...||||.|:.:|...: ||:|||.:|.|||..|.....|..
Zfish   264 GDYPESMRSRIENRSLELGYKQGSRLPHFSKDEPSPL-GTADFFALNYYTSRKVKDLSENTE--- 324

  Fly   351 PVPSFNHDMGVVESQEGV---DWPGSGSVWLKVYPKGMYNLLMWIHREYNAPEIIVTENGVSDRG 412
              .||..|.|.    |||   .||..|..||.|||:|:..||.:|...|.:..|.:||||.|..|
Zfish   325 --LSFVGDQGA----EGVIDPSWPICGVHWLAVYPEGLRKLLKYIKDTYTSVPIYITENGFSQMG 383

  Fly   413 --GLEDYARVDYYNLYLSAVLDAM-EDGANISGYIAWSLMDSYEWKAGFSEKFGLYHVDFNSPQR 474
              .:||..|..:|...|..|..|: :||.|:.||.||||:|::||..||:.:|||:||||:|.:.
Zfish   384 PVQIEDVDRSQFYEDTLQQVGKAISQDGVNVKGYFAWSLLDNFEWNDGFNVRFGLFHVDFSSSEL 448

  Fly   475 TRTPKISARVFAQL 488
            .||...|.|.:|.|
Zfish   449 KRTLYRSGRDYAAL 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9701	NP_648918.1	Glyco_hydro_1	22..492	CDD:304882	196/469 (42%)
gba3	NP_001018529.1	Glyco_hydro_1	9..466	CDD:304882	196/469 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592521
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2723
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H75140
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63440
OrthoDB	1	1.010	-	-		D257823at33208
OrthoFinder	1	1.000	-	-		FOG0000180
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100193
Panther	1	1.100	-	-	O	PTHR10353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3725
SonicParanoid	1	1.000	-	-		X89
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.790