DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dbp73D and DDX31

DIOPT Version :9

Sequence 1:	NP_476833.1	Gene:	Dbp73D / 39871	FlyBaseID:	FBgn0004556	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	XP_011517223.1	Gene:	DDX31 / 64794	HGNCID:	16715	Length:	787	Species:	Homo sapiens

Alignment Length:	689	Identity:	181/689 - (26%)
Similarity:	301/689 - (43%)	Gaps:	137/689 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KKAAKRKRKHEAIEVV-------ETPILEKETSDVKESE----SKEEQVEEPEKPLEVVQEEDVP 88
            ::|...|||::|....       ||..|..:.:.|||::    ...:::..|:|  ..|...|..
Human   130 RQAKATKRKYQASSEAPPAKRRNETSFLPAKKTSVKETQRTFKGNAQKMFSPKK--HSVSTSDRN 192

  Fly    89 SNEFQVLGGDDSAAKKKKVQMQLPNWLAHPTIIEGGSLQPEEEVPASEAIDQLDYLEKYTCQALK 153
            ..|.|.:    ..:...|....:|.  .|..:::    |.:|:|..|.|..:|. |..:....:.
Human   193 QEERQCI----KTSSLFKNNPDIPE--LHRPVVK----QVQEKVFTSAAFHELG-LHPHLISTIN 246

  Fly   154 Q-MKIKRLFPVQKQVIPWILEAHAKPPPFRPRDICVSAPTGSGKTLAFAIPIVQLLSQRVDCKVR 217
            . :|:..:..||||.||.:||.         ||..|.:.||||||||:.||:||.| |.::.|::
Human   247 TVLKMSSMTSVQKQSIPVLLEG---------RDALVRSQTGSGKTLAYCIPVVQSL-QAMESKIQ 301

  Fly   218 ------ALVVLPVAELALQVYRVISELCSK-TELEVCLLSKQHKLEDEQEKLVEQYKGKYYSKAD 275
                  |||::|..|||||.:..:.:|... |.:...:|....|.:.|:.:|   .||     .:
Human   302 RSDGPYALVLVPTRELALQSFDTVQKLLKPFTWIVPGVLMGGEKRKSEKARL---RKG-----IN 358

  Fly   276 IVVTTPGRLVDHLHATKGFCLKSLKFLVIDEADRIMDAVFQNWLYHLDSHVKETTDQLLAGTQAP 340
            |:::||||||||:.:||......|::||.||||||:|..|:          |:.|..|.|
Human   359 ILISTPGRLVDHIKSTKNIHFSRLRWLVFDEADRILDLGFE----------KDITVILNA----- 408

  Fly   341 LCYAELQASFGKQPHKLLFSATLSQDPEKLQDLRLFQPRLFATVLTMPVLKDA-----TEEGADT 400
             ..||.|     :...:|.||||::...:|.|:.|..|      :::.||..:     .::.|..
Human   409 -VNAECQ-----KRQNVLLSATLTEGVTRLADISLHDP------VSISVLDKSHDQLNPKDKAVQ 461

  Fly   401 EALTDP-GQFVGRYTTPAELTEQYCV--TELRLKPLTVFALVEKYKW---KRFLCFTNSSDQAT- 458
            |....| |..:..:..|..|.:...|  ::|||..|..| :::|.|:   ::.:.|.:|.:...
Human   462 EVCPPPAGDKLDSFAIPESLKQHVTVVPSKLRLVCLAAF-ILQKCKFEEDQKMVVFFSSCELVEF 525

  Fly   459 RLTFVLKVLFQKYSTKVS-------------ELSGNLSAKVRNERLRDFAAGKINGLICSDALAR 510
            ..:..|:.|........|             .|.|.:..:.|....::|:..:...|:|:|..||
Human   526 HYSLFLQTLLSSSGAPASGQLPSASMRLKFLRLHGGMEQEERTAVFQEFSHSRRGVLLCTDVAAR 590

  Fly   511 GIDVADVDVVLSYETPRHITTYIHRVGRTARAGRKGTAVTVLTEQDMTLFKKILSDANKGLGEEI 575
            |:|:..|..::.|..|.....||||:|||||.|..|:::.:|...:......:.|       .:|
Human   591 GLDLPQVTWIVQYNAPSSPAEYIHRIGRTARIGCHGSSLLILAPSEAEYVNSLAS-------HKI 648

  Fly   576 HVSPDIEIQHAVEYKEALAGL-RSEKVKNKNQKMAEKNRVATKALIHKKQEETATVRPLTLMEKL 639
            :||       .::.::.|..| |.:..|.|.....:.:.|..:.:     .|.|||        |
Human   649 NVS-------EIKMEDILCVLTRDDCFKGKRWGAQKSHAVGPQEI-----RERATV--------L 693

  Fly   640 QIKANEIVQSSKK----SSETKNSKTKADKTKYQPKETK 674
            |....:.|.||::    :.:...|..:|..|  .|:|.|
Human   694 QTVFEDYVHSSERRVSWAKKALQSFIQAYAT--YPRELK 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dbp73D	NP_476833.1	PRK11192	149..629	CDD:236877	140/513 (27%)
		DEAD	162..370	CDD:278688	77/214 (36%)
		HELICc	418..551	CDD:238034	39/151 (26%)
DDX31	XP_011517223.1	PRK01297	126..666	CDD:234938	163/608 (27%)
		DEADc	232..444	CDD:238167	84/257 (33%)
		HELICc	481..631	CDD:238034	39/150 (26%)
		DUF4217	693..754	CDD:290667	11/40 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920