DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dbp73D and ddx18

DIOPT Version :9

Sequence 1:	NP_476833.1	Gene:	Dbp73D / 39871	FlyBaseID:	FBgn0004556	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_001016776.1	Gene:	ddx18 / 549530	XenbaseID:	XB-GENE-6085268	Length:	640	Species:	Xenopus tropicalis

Alignment Length:	705	Identity:	181/705 - (25%)
Similarity:	289/705 - (40%)	Gaps:	151/705 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EDLKEQKDGAQGTNNEDEILQK------------LLKKAAKRKRKHEAIEVVETPILEKETSDVK 63
            |.:.|:::...|.||.:|..|.            ..||..|||...:| |..:....::|..:..
Frog    44 EGVAEEREEGDGVNNVEETQQNTSVDVGETSQPPTAKKKKKRKNAAKA-EGADAKKAKQEAPEGS 107

  Fly    64 ESESKEEQVEEPEKPLEVVQEEDVPSNEFQVLGGDDSAAKKKKVQMQLPNWLAHPTIIEGGSLQP 128
            :.|||.|...|.:...|..:|||.|:                     ||..|.       |:.:.
Frog   108 DQESKCENHVETKAEEEAEEEEDGPT---------------------LPMGLT-------GAFED 144

  Fly   129 EEEVPASEAIDQLDYLEKYTCQALKQMKIKRLFPVQKQVIPWILEAHAKPPPFRPRDICVSAPTG 193
            ......:|::::      .|.:|:.:|....:..:|.:.|..:||.         ||:..:|.||
Frog   145 TAFSSLAESVNE------NTLRAVTEMGFTHMTEIQHKAIRPLLEG---------RDVLAAARTG 194

  Fly   194 SGKTLAFAIPIVQLLSQRVDCKVR--------ALVVLPVAELALQVYRVISELCSKTELEVCLLS 250
            |||||||.||.::|:     .|::        .|::.|..|||:|.|.|:.||.:.......|:.
Frog   195 SGKTLAFLIPAIELV-----YKLKFMPRNGTGVLILSPTRELAMQTYGVLKELMAHHVHTFGLIM 254

  Fly   251 KQHKLEDEQEKLVEQYKGKYYSKADIVVTTPGRLVDHLHATKGFCLKSLKFLVIDEADRIMDAVF 315
            .......|.:||.        :..:|||.|||||:||:..|.||..|:|:.|||||||||::..|
Frog   255 GGSNRSAEAQKLA--------NGVNIVVATPGRLLDHMQNTPGFMYKNLQCLVIDEADRILEVGF 311

  Fly   316 QNWLYHLDSHVKETTDQLLAGTQAPLCYAELQASFGKQPHKLLFSATLSQDPEKLQDLRLFQPRL 380
                   :..:|:..:.|                 .|:...:|||||.::..|.|..:.|.:..|
Frog   312 -------EQEMKQIINLL-----------------PKRRQTMLFSATQTRKVEDLARISLKKEPL 352

  Fly   381 FATVLTMPVLKDATEEGADTEALTDPGQFVGRYTTPAELTEQYCVTELRLKPLTVFALVEKYKWK 445
            :..|       |..:|.|..:.| :.|..|             |.:|.|.  |.:|..::|.:.|
Frog   353 YVGV-------DDHKETATVDGL-EQGYVV-------------CPSEKRF--LLLFTFLKKNRKK 394

  Fly   446 RFLCFTNSSDQATRLTFVLKVLFQKYSTKVSELSGNLSAKVRNERLRDFAAGKINGLICSDALAR 510
            :.:.|. ||..:.:..:   .|.......|..:.|......|......|...:...|:|:|..||
Frog   395 KMMVFF-SSCMSVKYHY---ELLNYIDLPVMAIHGKQKQTKRTTTFFQFCNAESGILLCTDVAAR 455

  Fly   511 GIDVADVDVVLSYETPRHITTYIHRVGRTARA--GRKGTAVTVLTEQDMTLFKKILSDANKGLGE 573
            |:|:.:||.::.|:.|.....||||||||||.  || |.|:.:|..:::. |.:.|..|...|.|
Frog   456 GLDIPEVDWIVQYDPPDDPKEYIHRVGRTARGIDGR-GHALLILRPEELG-FLRYLKQAKVPLSE 518

  Fly   574 -EIHVSPDIEIQHAVEYKEALAGLRSEKVKNKNQKMAEKNRVATKALI-------HKKQEETATV 630
             |...|...:||           .:.||:..||..:.:..:.|.||.|       ||:..:..|:
Frog   519 FEFSWSKISDIQ-----------TQLEKLIEKNYYLHKSAQEAYKAYIRAYDSHSHKQIFDVNTL 572

  Fly   631 RPLTLMEKLQIKANEIVQSSKKSSETKNSKTKADKTKYQPKETKKQIIAKQLKAI 685
            ....:......:....|..:..||..|..:.:.....:..:::..|..||..|.|
Frog   573 NLPKVAISFGFQVPPFVDLNVNSSGGKRLQKRGGGGGFGYQKSNNQHKAKIFKHI 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dbp73D	NP_476833.1	PRK11192	149..629	CDD:236877	140/497 (28%)
		DEAD	162..370	CDD:278688	68/215 (32%)
		HELICc	418..551	CDD:238034	40/134 (30%)
ddx18	NP_001016776.1	SrmB	145..634	CDD:223587	152/575 (26%)
		DEADc	147..354	CDD:238167	75/258 (29%)
		HELICc	368..497	CDD:238034	43/149 (29%)
		DUF4217	529..587	CDD:290667	13/68 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010