DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dbp73D and Ddx56

DIOPT Version :9

Sequence 1:	NP_476833.1	Gene:	Dbp73D / 39871	FlyBaseID:	FBgn0004556	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_080814.1	Gene:	Ddx56 / 52513	MGIID:	1277172	Length:	546	Species:	Mus musculus

Alignment Length:	597	Identity:	159/597 - (26%)
Similarity:	242/597 - (40%)	Gaps:	155/597 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 LEKYTCQALKQMKIKRLFPVQKQVIPWILEAHAKPPPFRPRDICVSAPTGSGKTLAFAIPIVQLL 208
            |:....||:..:...|...:|::.||..||.         :|:...|.||||||.|:|||::|.|
Mouse    14 LDPRLLQAVTDLGWSRPTLIQEKAIPLALEG---------KDLLARARTGSGKTAAYAIPMLQSL 69

  Fly   209 SQR------VDCKVRALVVLPVAELALQVYRVISEL---CSKTELEVCLLSKQHKLEDEQEKLVE 264
            ..:      ::..||.||::|..|||.|...:|.:|   |:: ::.|..:|.......::..|:|
Mouse    70 LHKKATGPVMEQAVRGLVLVPTKELARQAQAMIQQLAAYCAR-DVRVANVSAAEDSASQRAVLME 133

  Fly   265 QYKGKYYSKADIVVTTPGRLVDHLHATKGFCLKSLKFLVIDEADRIMDAVFQNWLYHLDSHVKET 329
                    |.|:||.||.|::.||.........||:.||:||||.:....|::.|..|..|:
Mouse   134 --------KPDVVVGTPSRVLSHLQQNTLKLRDSLELLVVDEADLLFSFGFEDELKSLLCHL--- 187

  Fly   330 TDQLLAGTQAPLCYAELQASFGKQPHKLLFSATLSQDPEKLQDLRLFQPRLFATVLTMPVLKDAT 394
                      |..|   ||        .|.|||.::|.:.|::|.|..|      :|:.:.:...
Mouse   188 ----------PRIY---QA--------FLMSATFNEDVQTLKELVLHNP------VTLKLQESQL 225

  Fly   395 EEGADTEALTDPGQFVGRYTTPAELTEQY---CVTE----LRLKPLTVFALVEKYKWKRFLCFTN 452
                       ||        |.:| :|:   |.||    |.|..|...:|:.    .:.|.|.|
Mouse   226 -----------PG--------PDQL-QQFQVVCETEEDKFLLLYALLKLSLIR----GKALLFVN 266

  Fly   453 SSDQATRLTFVLKVLFQKYSTKVSELSGNLSAKVRNERLRDFAAGKINGLICSDA---------- 507
            :.::..|    |::..:::|.....|:|.|..:.|...:..|..|..:.:|.:||
Mouse   267 TLERGYR----LRLFLEQFSIPSCVLNGELPLRSRCHIISQFNQGLYDCVIATDAEILGPQVKGK 327

  Fly   508 -----------------LARGIDVADVDVVLSYETPRHITTYIHRVGRTARAGRKGTAVTVLTEQ 555
                             :|||||...|..||:::.|.....|:||.||||||...|..:|.:...
Mouse   328 RRGRGSKGNKASDPESGVARGIDFHHVSAVLNFDLPPTAEAYVHRAGRTARANNPGIVLTFVLPA 392

  Fly   556 DMTLFKKILSDANKGLGEEIHVSP------DIE-----------------IQHA--VEYKEALAG 595
            :.....|| .|...|.||...:.|      :||                 |:.|  .|.||.|
Mouse   393 EQPFLGKI-EDLLSGEGEAPILLPYQFQMEEIESFRYRCRDAMRSVTKQAIREARLKEIKEEL-- 454

  Fly   596 LRSEKVKNKNQKMAEKNRVATKALIHKKQEETATVRP-LTLMEKLQIKA--NEIVQSSKKSSETK 657
            |.|||:|.    ..|.|....:.|.|......|.|:| |..:....:.|  ..:|...||..:..
Mouse   455 LHSEKLKT----YFEDNPRDLQLLRHDLPLHPAVVKPHLGHVPDYLVPAALRGLVHPRKKRRKVP 515

  Fly   658 NSKTKADKTKYQ 669
            .|: ||.|.|.|
Mouse   516 FSR-KAKKVKAQ 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dbp73D	NP_476833.1	PRK11192	149..629	CDD:236877	144/547 (26%)
		DEAD	162..370	CDD:278688	65/216 (30%)
		HELICc	418..551	CDD:238034	43/166 (26%)
Ddx56	NP_080814.1	Q motif	7..35		4/20 (20%)
		SrmB	9..544	CDD:223587	159/597 (27%)
		P-loop_NTPase	9..219	CDD:304359	74/252 (29%)
		DEAD box	166..169		2/2 (100%)
		HELICc	234..388	CDD:238034	41/161 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..344		0/19 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..546		8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010