DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dbp73D and ddx1

DIOPT Version :9

Sequence 1:	NP_476833.1	Gene:	Dbp73D / 39871	FlyBaseID:	FBgn0004556	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_001011133.1	Gene:	ddx1 / 496549	XenbaseID:	XB-GENE-969096	Length:	740	Species:	Xenopus tropicalis

Alignment Length:	677	Identity:	139/677 - (20%)
Similarity:	235/677 - (34%)	Gaps:	237/677 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 DVPSNEFQV-LGGDDSAAKKKKVQMQLPNWLAHPTI-----IEGGSLQPEE---------EVPA- 134
            |:.:::|.. .||....:..|:.......:..|.||     |:.|:::..:         ::||
Frog   157 DLGTDKFGFGFGGTGKKSHNKQFDNYGEEFTMHDTIGCYIDIDNGTVKYSKNGKDLGLAFQIPAH 221

  Fly   135 --SEAIDQLDYLEKYTCQALKQMKIKRLFPVQKQVIPWILEAHAKPPPFRPRD------------ 185
              ::|:        :....||..::|..|..:....|             |:|
Frog   222 LKNQAV--------FASCVLKNAELKFNFGEEDFKFP-------------PKDGFVALSKAPDGH 265

  Fly   186 ICVSAPTGSGKTLAFAIPIVQLLSQRVDCKVRALVVLPVAELALQVYRVISELCSKTELEVCLLS 250
            :..|..|||.:...         ::.:....:||::.|..|||.|....:.:.....:
Frog   266 VVKSQNTGSAQVSQ---------AKNLPNAPKALIIEPSRELAEQTLNNVKQFKKYVD------- 314

  Fly   251 KQHKLED----------EQEKLVEQYKGKYYSKADIVVTTPGRLVDHLHATKGFCLKSLKFLVID 305
             ..||.:          ||..|:|       :..||||.|||| :|.|.:|....|..::|||:|
Frog   315 -SPKLRELLIIGGVAAKEQLTLLE-------NGVDIVVGTPGR-IDDLISTGKLNLSQVRFLVLD 370

  Fly   306 EADRIMDAVFQNWLYHLDSHVKETTDQLLAGTQAPLCYAELQASFGKQPHKLLFSATL-SQDPEK 369
            |||.::...:.:::..:...:.:.|                  |.||:...::.|||| |.|.:|
Frog   371 EADGLLSQGYSDFINRIHGQIPQVT------------------SDGKRLQVIVCSATLHSFDVKK 417

  Fly   370 LQDLRLFQP---------RLFATV--LTMPVL----------------------KDATEEGADTE 401
            |.:..:..|         .:..||  :.:||.                      ||.|..|.::.
Frog   418 LSEKIMHFPTWVDLKGEDSVPETVHHVVVPVNPKKDKQWERLGKNHIRTDGVHDKDNTRPGGNSA 482

  Fly   402 ALTDPGQFV--GRYTTPAELTEQYCVTELRLKPLTVFAL-------VEKY----------KWKRF 447
            .:......|  |.||..|       :.|.::....:|..       :|:|          |..:|
Frog   483 EMWSEAIKVLKGEYTVRA-------IKEHKMDQAIIFCRTKLDCDNMEQYFIQQGGGPDKKGHQF 540

  Fly   448 LCFTNSSDQATRLTFVLKVLFQKYSTKVSELSGNLSAKVRNERLRDFAAGKINGLICSDALARGI 512
            .|....||:                 |..|         |...|..|...::..|||:|..||||
Frog   541 SCVCLHSDR-----------------KPQE---------RKHNLERFKKCEVRFLICTDVAARGI 579

  Fly   513 DVADVDVVLSYETPRHITTYIHRVGRTARAGRKGTAVTVLTEQDMTLFKKILSDANKG------- 570
            |:..|..|::...|.....|:||:||..||.|.|.|::::..:...::..:.|...||
Frog   580 DIHGVPYVINVTLPDEKQNYVHRIGRVGRAERMGLAISLVAAEKEKVWYHVCSSRGKGCHNTRLK 644

  Fly   571 --------------LGE-EIH-------VSPDIEIQHAVEYKEALAGLRSEKVKNKNQKMAEKNR 613
                          |.| |.|       |.|||::                .:...:.|:....|
Frog   645 EDGGCTIWYNETQLLSEIEEHLTCTISQVEPDIKV----------------PLDEFDGKVVYGQR 693

  Fly   614 VATKALIHKKQEE--TATVRPLTLMEK 638
            .||...::|...:  ..||:.|..:||
Frog   694 RATGGGLYKGHVDILAPTVQELAALEK 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dbp73D	NP_476833.1	PRK11192	149..629	CDD:236877	121/585 (21%)
		DEAD	162..370	CDD:278688	49/230 (21%)
		HELICc	418..551	CDD:238034	36/149 (24%)
ddx1	NP_001011133.1	Interaction with dsRNA. /evidence=ECO:0000250\|UniProtKB:Q91VR5	1..448		71/354 (20%)
		DEAD-like_helicase_N	4..>64	CDD:391939
		SPRY_DDX1	93..246	CDD:293933	17/96 (18%)
		DEADc_DDX1	264..430	CDD:350696	49/208 (24%)
		SrmB	284..>624	CDD:223587	94/406 (23%)
		DEAD box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	370..373		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010