DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dbp73D and ddx51

DIOPT Version :9

Sequence 1:	NP_476833.1	Gene:	Dbp73D / 39871	FlyBaseID:	FBgn0004556	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_001003864.1	Gene:	ddx51 / 445387	ZFINID:	ZDB-GENE-040927-28	Length:	652	Species:	Danio rerio

Alignment Length:	701	Identity:	255/701 - (36%)
Similarity:	348/701 - (49%)	Gaps:	146/701 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELFTVNRYTEDLKEQKDGAQGTNNEDEILQKLLKKAAKR----------------------KRK 43
            |.|||:|||..:  |:::.::..:....:|.||.|:...|                      |||
Zfish     1 MALFTINRYLGE--EEEEDSEKQSRSKALLAKLQKQVKARGQQSVSNTPKEEEEQQDDKEHKKRK 63

  Fly    44 HEAIE----------VVETPILEKETSDVKESESK-------------EEQVEEPEKPLEVV--- 82
            |:..|          |..|...|:..|.||:.:.:             ||...|.||.:::.
Zfish    64 HKLQETKGKIKKSESVQNTDPTEEADSSVKKKKKRKKSLSTEDVIVKIEENESENEKSVDITGPT 128

  Fly    83 ----------QEEDVPS---NEFQVLGGDDSAAKKK---KVQMQLPNWLAHPTIIE---GGSLQP 128
                      :.|::.|   :.:|||||    .|:|   ||:..||.||:.|.:|:   ..:|.|
Zfish   129 PSSPVQFKAEKAEELTSSSQSNYQVLGG----FKEKDVQKVKRVLPQWLSQPDVIQKDIKSNLIP 189

  Fly   129 EEEVPASEAIDQLDYLEKYTC----QALKQMKIKRLFPVQKQVIPWILEAHAK-----PPPFRPR 184
            ..|||.             .|    :.|:...|:..||||.:|||.|||:...     |..:|||
Zfish   190 ISEVPG-------------ICPTLLRKLQTNGIQSFFPVQAEVIPAILESVGSGLLVGPGGYRPR 241

  Fly   185 DICVSAPTGSGKTLAFAIPIVQLLSQRVDCKVRALVVLPVAELALQVYRVISELCSKTELEVCLL 249
            |:||||||||||||||.||:||.||:||..:||||.|||..|||.||..|.|.....:.|:|.::
Zfish   242 DVCVSAPTGSGKTLAFVIPVVQALSKRVVRQVRALAVLPTKELAQQVSNVFSAYTEGSSLKVVMI 306

  Fly   250 SKQHKLEDEQEKLVEQYKGKYYSKADIVVTTPGRLVDHLHATKGFCLKSLKFLVIDEADRIMDAV 314
            :.|.....||..|.|...|..:|.|||||.||||||||::....|.|:.|:||:||||||::|::
Zfish   307 TGQKSFAAEQTALSEIRGGVSHSMADIVVATPGRLVDHINKNSSFSLQHLRFLIIDEADRMIDSM 371

  Fly   315 FQNWLYHLDSHVKET-----------------TDQLLAGTQAPLCYAELQASFGKQPHKLLFSAT 362
            .|:||..:...|..|                 |...|:..|.||             .|||||||
Zfish   372 HQSWLSQVTKAVYSTPGETHTSVFRRTVPGPITAASLSPPQIPL-------------QKLLFSAT 423

  Fly   363 LSQDPEKLQDLRLFQPRLFATVLTMPVLKDATEEGADTEALTD-PGQFVGRYTTPAELTEQYCVT 426
            |:|:|||||.|.|.|||||::                |.:||| |.|....:..|..|:|.|...
Zfish   424 LTQNPEKLQLLDLHQPRLFSS----------------THSLTDNPAQSQDTFHFPQGLSEYYVPC 472

  Fly   427 ELRLKPLTVFALVEKYKWKRFLCFTNSSDQATRLTFVLKVLFQKYSTKVSELSGNLSAKVRNERL 491
            ....|||.:...:.:.|:...||||||.:.|.||..::| ||.  ..:|:|.|..||...|.:.|
Zfish   473 TFSKKPLIILHFLLRLKFSPALCFTNSREGAHRLYLLVK-LFG--GVEVAEFSSKLSPGERQKTL 534

  Fly   492 RDFAAGKINGLICSDALARGIDVADVDVVLSYETPRHITTYIHRVGRTARAGRKGTAVTVLTEQD 556
            :||..|||..||.:||.|||||:..|..|::|:.|::|.|||||||||||||:.|.|.|.|.:..
Zfish   535 KDFEKGKIPLLISTDAAARGIDINGVKCVINYDAPQYIRTYIHRVGRTARAGKAGLAFTFLLKVQ 599

  Fly   557 MTLFKKILSDANKGLGEEIHVSPDIEIQHAVEYKEALAGLRSEKVKNKNQK 607
            ...|.|::|||.....::.||.|:........|::.||.| ...||.:|:|
Zfish   600 EKRFLKMVSDAGSPGIQKQHVHPEALKSMESRYEQVLAEL-GTIVKEENEK 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dbp73D	NP_476833.1	PRK11192	149..629	CDD:236877	204/486 (42%)
		DEAD	162..370	CDD:278688	105/229 (46%)
		HELICc	418..551	CDD:238034	60/132 (45%)
ddx51	NP_001003864.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..145		30/145 (21%)
		P-loop_NTPase	195..439	CDD:304359	114/269 (42%)
		DEXDc	204..451	CDD:214692	121/275 (44%)
		Q motif	212..220		4/7 (57%)
		DEAD box	362..365		2/2 (100%)
		Helicase_C	475..586	CDD:278689	53/113 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595872
Domainoid	1	1.000	175	1.000	Domainoid score	I3613
eggNOG	1	0.900	-	-		E2759_KOG0350
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6850
Inparanoid	1	1.050	330	1.000	Inparanoid score	I2429
OMA	1	1.010	-	-		QHG55255
OrthoDB	1	1.010	-	-		D303117at33208
OrthoFinder	1	1.000	-	-		FOG0005234
OrthoInspector	1	1.000	-	-		oto38592
orthoMCL	1	0.900	-	-		OOG6_103754
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R292
SonicParanoid	1	1.000	-	-		X3754
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800