DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dbp73D and mus301

DIOPT Version :9

Sequence 1:	NP_476833.1	Gene:	Dbp73D / 39871	FlyBaseID:	FBgn0004556	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_648178.1	Gene:	mus301 / 38905	FlyBaseID:	FBgn0002899	Length:	1051	Species:	Drosophila melanogaster

Alignment Length:	792	Identity:	159/792 - (20%)
Similarity:	275/792 - (34%)	Gaps:	222/792 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FTVNRYTEDL----KEQKDGAQGTNNEDEILQKLLKKAAKRKRKHEAIEVVETPILEKETSDVKE 64
            |..|.:.|||    ||:..|.|.|.:.:::.|         ....:.:.:..........|....
  Fly    44 FFSNAHLEDLLDGRKEELFGTQATTSTNKMTQ---------SGSDDGLGLFADTSFPSAQSVPPN 99

  Fly    65 SESKEEQVEEP--EKPLEVVQEED-------VPSNEFQVL-------GGDD-SAAKKKKVQMQL- 111
            |.||.::...|  :..:::..||:       :..|:..:.       |.|| |....:..|:.|
  Fly   100 SASKPDEASAPTDKHQIDLADEENADKLFKKINLNDLSIAEMEDIFHGADDFSDPMVQNTQLFLD 164

  Fly   112 ---------PNWLAHP-----------TIIEGGSLQPEEEVPASEAIDQ--LDYLEKYTCQALKQ 154
                     |..|..|           ::|| |.:|..:.|...|..:|  ||.: .:..||...
  Fly   165 AMTFKKPKTPEKLLAPLKDDSMSFISKSVIE-GLVQGTQYVTCEELKNQSLLDPV-NWETQAFAD 227

  Fly   155 M---------------------KIKRLFPVQK---QVIPWILEAHAKPPPFRPRDICVSAPTGSG 195
            .                     |:|::....|   .:..|..|....|...:.:::..:.||..|
  Fly   228 FEKNNQDIDKFPSKGEFYGLPDKVKKMILEHKGINSLYEWQDECLNLPAIRQRKNLIYALPTSGG 292

  Fly   196 KTLAFAIPIVQLLSQRVDCKVR-ALVVLPVAELALQVYRVISELCSKTELEVCLLSKQHKLEDEQ 259
            |||...|    |:.:.:.|:.| .|.:||...:..:....:|......:.
  Fly   293 KTLVAEI----LMLRELLCRERNVLFILPYVSIVQEKVSAMSPFAIDLDF--------------- 338

  Fly   260 EKLVEQYKGKYYSKADIVVTTPGRLVDHLHATKGFC-------LKSLKFLVIDEADRIMDAVFQN 317
              :||:|.                      |.||.|       .:||....|::...:||::...
  Fly   339 --IVEEYT----------------------AGKGKCPPQPRRKRRSLFIASIEKGAVLMDSLIDV 379

  Fly   318 WLYHLDSHVKETTDQL-LAGTQAPLCYAELQASFGKQPHKLLF----------SATLSQDPEKLQ 371
            ...|....|  ..|:| |.|.:..  .|.|:|..    .|::|          |||:.    .|.
  Fly   380 QRPHEIGLV--VVDELHLIGEKGR--GATLEAFL----TKVMFLNANIQIVGMSATIG----NLS 432

  Fly   372 DLRLFQPRLFATVLT---MPV-LKDATEEGADTEALTDPGQFVGRYTTPAELTE-QYCVTELRLK 431
            ::..|   |.|.|.|   .|| ||:..:.|.|...:...||.:.....|:...| .|.....|..
  Fly   433 EISSF---LNADVYTRGFRPVELKEYIKCGPDLLEINSAGQTLEEIFVPSRSVEYNYSEAVKRAD 494

  Fly   432 PLTVFALVEKYKWKR-FLCFTNSSDQATRLTFVLKVLFQKY-------STK------VSELSGNL 482
            |..:..|:.:...:. .|.|..|......:..:|..:..|:       |.|      :.::.|.|
  Fly   495 PDHLAGLISECAPEHCCLVFCPSRKNCENVALLLSRIVPKHKFFEHRRSEKLDLMDALDKMCGIL 559

  Fly   483 S---AK-------------VRNERL---RDFAAGKINGLICSDALARGIDVADVDVVL--SYETP 526
            |   ||             ..:||.   ..:..|.:..:.|:..||.|:::....|::  .|...
  Fly   560 SPVLAKTLPYGIAYHHSGLTTDERKYIETAYRFGVVTVICCTSTLAAGVNLPAKRVIIRAPYVGQ 624

  Fly   527 RHIT--TYIHRVGRTARA--GRKGTAVTVLTEQDMTLFKKIL-SDANKGLGEEIHVSPDIEIQHA 586
            ..:|  .|...|||..||  |..|.::.:...:|..|..::| |..:|.|.             :
  Fly   625 EFLTLCKYKQMVGRAGRAGLGEAGESILIAQSKDNLLVGQMLFSPMDKALS-------------S 676

  Fly   587 VEYKEALAGLRSEKVKNKNQKMAE----KNRVATKAL--IHKKQEETATVRPLTLMEKLQIKANE 645
            ::..||: ||:|..:......:||    .||:....|  :..|..|.| |..:.|....::..|:
  Fly   677 LDQNEAV-GLQSLILSVVGLNLAECRRDLNRLVNSTLLSVQAKSLEVA-VNEIVLRILREMFKNK 739

  Fly   646 IVQSSKKSSETK 657
            ::|.::..:::|
  Fly   740 VLQLAEPQAKSK 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dbp73D	NP_476833.1	PRK11192	149..629	CDD:236877	116/573 (20%)
		DEAD	162..370	CDD:278688	44/229 (19%)
		HELICc	418..551	CDD:238034	35/172 (20%)
mus301	NP_648178.1	BRR2	247..998	CDD:224125	120/578 (21%)
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	52/259 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100