DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dbp73D and CG32344

DIOPT Version :9

Sequence 1:	NP_476833.1	Gene:	Dbp73D / 39871	FlyBaseID:	FBgn0004556	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_612028.4	Gene:	CG32344 / 326208	FlyBaseID:	FBgn0052344	Length:	827	Species:	Drosophila melanogaster

Alignment Length:	670	Identity:	166/670 - (24%)
Similarity:	262/670 - (39%)	Gaps:	182/670 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 RKHEAIEVVETPILEKET------SDVKESESKEEQVEEPEKPLEVVQEEDVPSNEFQVLGGDDS 100
            ||.:|.|:...|.|:.:.      :|:.:|:||:.:                 |..||.:|....
  Fly     2 RKKQADEIPGFPSLDNDAGTSDRGADILKSKSKKNK-----------------SGGFQSMGLGFE 49

  Fly   101 AAKKKKVQMQLPNWLAHPTIIEGGSLQPEEEVPASEAIDQLDYLEKYTCQALKQMKIKRLFPVQK 165
            ..|                    |..:...:||.                           |:|:
  Fly    50 LIK--------------------GITKRGYKVPT---------------------------PIQR 67

  Fly   166 QVIPWILEAHAKPPPFRPRDICVSAPTGSGKTLAFAIPIVQLLSQRVDCK-VRALVVLPVAELAL 229
            :.||.|||.         ||:...|.||||||..|.||:.:.|.:|...| .|||::.|..|||:
  Fly    68 KTIPLILEG---------RDVVAMAKTGSGKTACFLIPLFEKLQRREPTKGARALILSPTRELAV 123

  Fly   230 QVYRVISELCSKTELEVCLLSKQHKLEDEQEKLVEQYKGKYYSKADIVVTTPGRLVDHLHATKGF 294
            |.|:.|.||....||:..|:.....::.:...:        ::..|::|.||||.: ||......
  Fly   124 QTYKFIKELGRFMELKSILVLGGDSMDSQFSAI--------HTCPDVIVATPGRFL-HLCVEMDL 179

  Fly   295 CLKSLKFLVIDEADRIMDAVFQNWLYHLDSHVKETTDQLLAGTQAPLCYAELQASFGKQPHKLLF 359
            .|.|::::|.|||||:.:..|       ...:.||..:|.:..|.                 ::|
  Fly   180 KLNSIEYVVFDEADRLFEMGF-------GEQLNETLHRLPSSRQT-----------------VMF 220

  Fly   360 SATLSQDPEKLQDLRLFQPRLFATV-LTMPVLKDATEEGADTEALTDPGQFVGRYTTPAELTEQY 423
            ||||   |:.|.:        ||.. |..|||.....|....:||.              |...|
  Fly   221 SATL---PKLLVE--------FARAGLNDPVLIRLDVESKLPDALA--------------LKFLY 260

  Fly   424 CVTELRLKPLTVFALVEKY---KWKRFLCFTNSSDQATRLTFVLKVLFQKYSTKVSELS--GNLS 483
            |..:.|...|.|..   ||   ...:.:.|..:......::::|.      ...:|..|  .:|.
  Fly   261 CRPDDRYTALVVLL---KYVIPVQSQTVVFAGTQHHVELISYILT------EAGISNASVYSSLD 316

  Fly   484 AKVRNERLRDFAAGKINGLICSDALARGIDVADVDVVLSYETPRHITTYIHRVGRTARAGRKGTA 548
            ...|......|...|::.||.:|..|||||:..:|.|::...|.....::|||||.|||||.|||
  Fly   317 PAARKINTAKFVNKKVSVLIVTDVAARGIDIPSLDFVVNLHFPGKPKLFVHRVGRCARAGRTGTA 381

  Fly   549 VTVLTEQ------DMTLF---------KKILSDANKGLGEEIHVS-PDIEIQHAVEYKEALAG-L 596
            .::::..      |:.||         ...|....:.|.||.|:: .||:..|.:      || |
  Fly   382 YSIVSTDDTAHLLDLHLFLNRPFNIHDSSALGTIPQDLLEEEHLTVTDIKKSHHI------AGVL 440

  Fly   597 RSEKVKNKNQKMAEKNRVA-TKALIHKKQEETATVRPLTLMEKLQIKANEIVQSSKKSSETKNSK 660
            |:.  :|..:|......|| |.|....|:.:...::||   |.....|..:.|:::.|.::..|:
  Fly   441 RTS--ENAYKKYLSSRPVASTDANARVKKIKFFALKPL---EDFFTAAPVLAQAAEASGQSTESQ 500

  Fly   661 TKADKTKYQPKETKKQIIAK 680
            .|....:.:.:|.|..|:.|
  Fly   501 AKVSAAERKLQEEKHDILVK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dbp73D	NP_476833.1	PRK11192	149..629	CDD:236877	136/504 (27%)
		DEAD	162..370	CDD:278688	64/208 (31%)
		HELICc	418..551	CDD:238034	40/137 (29%)
CG32344	NP_612028.4	DEADc	41..243	CDD:238167	78/301 (26%)
		DEXDc	54..243	CDD:214692	73/268 (27%)
		HELICc	263..384	CDD:238034	37/129 (29%)
		DBP10CT	666..721	CDD:285373
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451646
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030