DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dbp73D and ddx31

DIOPT Version :9

Sequence 1:	NP_476833.1	Gene:	Dbp73D / 39871	FlyBaseID:	FBgn0004556	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	XP_021327284.1	Gene:	ddx31 / 325248	ZFINID:	ZDB-GENE-030131-3973	Length:	739	Species:	Danio rerio

Alignment Length:	759	Identity:	184/759 - (24%)
Similarity:	322/759 - (42%)	Gaps:	157/759 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QKDGAQGTNNEDEILQKLLKKAAKRKRKHEAIEVVETPI-LEKETSDVKESESKEEQVEEPEKPL 79
            :|...:..::.::..||  |:.||||   .|:|..|:.: .:::.:...:..::::.::.|..|.
Zfish    19 RKTNQKHLSSSEKWAQK--KRVAKRK---AAVEPQESSVSKQRKINQTGQQHAQKQTLQTPRSPS 78

  Fly    80 EVVQEEDVPSNEFQVLGGDDSAAK---------KK-------------KVQMQLPNWLAHPTIIE 122
            :.....|...:..|   .::|.||         ||             |......|....|.::.
Zfish    79 QRSNNRDTEESPVQ---RENSEAKSPSKVKTFPKKAPTEHEDHGRPFIKTSSLFRNNPEIPDVLS 140

  Fly   123 GGSLQPEEEVPASEAIDQLDYLEKYTCQALKQMKIKRLFPVQKQVIPWILEAHAKPPPFRPRDIC 187
            ....|.:|:|..|...::|:..........|.:.:..:..||||.||.::..         :|..
Zfish   141 PAVNQVKEKVFTSNTFEELNLHPHLVATLHKVLNVSSMTSVQKQTIPVLMSG---------KDAV 196

  Fly   188 VSAPTGSGKTLAFAIPIVQLLSQRVDCKVR------ALVVLPVAELALQVYRVISELCSK-TELE 245
            |.:.||||||||:.||:||.| |.:..||:      |:|::|..|||||.:::..:|... |.:.
Zfish   197 VRSQTGSGKTLAYGIPMVQFL-QAIQPKVKRSDGPLAVVIVPTRELALQSFQMFQKLLRPFTWIV 260

  Fly   246 VCLLSKQHKLEDEQEKLVEQYKGKYYSKADIVVTTPGRLVDHLHATKGFCLKSLKFLVIDEADRI 310
            ..:|....|.:.|:.:|   .||     .:::::||||||||:..|......::::|::||||||
Zfish   261 PGVLMGGEKKKAEKARL---RKG-----INVLISTPGRLVDHIKNTLSIAFSAVRWLILDEADRI 317

  Fly   311 MDAVFQNWLYHLDSHVKETTDQLLAGTQAPLCYAELQASFGKQPHKLLFSATLSQDPEKLQDLRL 375
            :|..|:          |:.|..|.|...|           |.....:|.|||:::...:|..:.:
Zfish   318 LDLGFE----------KDLTVILNALNTA-----------GPYRQNVLLSATITEGLSRLASISM 361

  Fly   376 FQPRLFATVLTMPVLKDATEEGADTEALTDPGQFVGRYTTPAELTEQYCV--TELRLKPLTVFAL 438
            ..|      :::.| .:.:||..:......|......|..|..|.:...|  ::|.|..|..|.|
Zfish   362 KDP------VSVHV-SEGSEETVEACPQAAPQALSDSYAVPERLQQHVVVVPSKLHLVCLAAFIL 419

  Fly   439 VE-KYKWKRFLCFTNSSDQATR-----LTFVLKVLFQKYSTKVS------ELSGNLSAKVRNERL 491
            .: |::.::.|....||.:|..     .|.||..:....|:|.:      .|.||:..:.|.|..
Zfish   420 AKCKFEQRQKLVIFISSCEAVEFLLNLFTAVLCEIPSNTSSKSTSCLNFYRLHGNMRQEERTEVF 484

  Fly   492 RDFAAGKINGLICSDALARGIDVADVDVVLSYETPRHITTYIHRVGRTARAGRKGTAVTVLTEQD 556
            ::|:..|...|:|:|..|||:|:..|..::.|..|.....|:||||||||.|.:|:::..||..:
Zfish   485 QEFSQCKTGILLCTDVAARGLDLPQVTWIVQYNPPVSAAEYVHRVGRTARIGAQGSSLLFLTPSE 549

  Fly   557 MTLFKKILSDANKGLGEEIHVSPDIEIQHAVEYKEALAGLRSEKVK------NKNQKMAEKNRVA 615
             |.|..:|::.|..|.|          ...|:....|  ::.|:.|      :|....|.:..|.
Zfish   550 -TAFVDVLANHNISLSE----------MKMVDILSTL--MKDERFKGRGKWDSKRSADAFEQEVR 601

  Fly   616 TKA---------LIHKKQEETATVR-------------PLTLMEKLQIKANEIVQSSK------- 651
            .:|         .:|...|...|.:             |.:|.....|:...:..::|
Zfish   602 ERATLLQTDFENYVHASNESLQTAKSALQCFLRAYTTYPSSLKHIFHIRMLHLGHAAKSFGLRDA 666

  Fly   652 ----------KSSETKNSKTKADKTKYQPKE-TKKQIIAKQLKA 684
                      ..:.:|:||...||.|..||: |.||.::..:::
Zfish   667 PQGLASSISTNPANSKHSKKAKDKAKSPPKKLTAKQRVSNLMRS 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dbp73D	NP_476833.1	PRK11192	149..629	CDD:236877	140/515 (27%)
		DEAD	162..370	CDD:278688	68/214 (32%)
		HELICc	418..551	CDD:238034	45/146 (31%)
ddx31	XP_021327284.1	SrmB	124..613	CDD:223587	146/547 (27%)
ddx31	XP_021327284.1	DUF4217	607..668	CDD:316476	7/60 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920