DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dbp73D and Ddx31

DIOPT Version :9

Sequence 1:	NP_476833.1	Gene:	Dbp73D / 39871	FlyBaseID:	FBgn0004556	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_001101294.2	Gene:	Ddx31 / 311835	RGDID:	1304895	Length:	682	Species:	Rattus norvegicus

Alignment Length:	693	Identity:	184/693 - (26%)
Similarity:	302/693 - (43%)	Gaps:	166/693 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 KRKHEAIEVVETPILEKETSDV--KESESKEEQ---------VEEPEKPLEVV---QEEDVP--- 88
            ||||:............|.|.:  |::.:||.|         ...|:|.|:.:   ::|:.|
  Rat     9 KRKHQVSSDAPPAKRRNEISSLSAKKASNKETQRAFKGSAHKTFPPKKHLDTIGNERQEEKPCVK 73

  Fly    89 -SNEFQVLGGDDSAAKKKKVQMQLPNWLAHPTIIEGGSLQPEEEVPASEAIDQLDYLEKYTCQAL 152
             |:.|             |...::|.  .|.|:::    |..|:|.:.||..:|| |..:....:
  Rat    74 TSSLF-------------KNNPEIPE--LHRTVVK----QAREQVFSPEAFQELD-LHPHLISTI 118

  Fly   153 KQ-MKIKRLFPVQKQVIPWILEAHAKPPPFRPRDICVSAPTGSGKTLAFAIPIVQLLSQRVDCKV 216
            .. :|:..:..||||.||.:||.         ||..|.:.||||||||:.||:||.| |.:..|:
  Rat   119 NTVLKMSSMTSVQKQSIPVLLEG---------RDALVRSQTGSGKTLAYCIPVVQSL-QALTSKI 173

  Fly   217 R------ALVVLPVAELALQVYRVISELCSK-TELEVCLLSKQHKLEDEQEKLVEQYKGKYYSKA 274
            :      |||::|..|||||.:..:.:|... |.:...:|....|.:.|:.:|   .||     .
  Rat   174 QRSDGPYALVLVPTRELALQSFDTVQKLLKPFTWIVPGVLMGGEKRKSEKARL---RKG-----I 230

  Fly   275 DIVVTTPGRLVDHLHATKGFCLKSLKFLVIDEADRIMDAVFQNWLYHLDSHVKETTDQLLAGTQA 339
            :|:::||||||||:.:||......:::||:||||||:|..|:          |:.|..|.|
  Rat   231 NILISTPGRLVDHIKSTKNIHFNRVRWLVVDEADRILDLGFE----------KDVTVILNA---- 281

  Fly   340 PLCYAELQASFGKQPHKLLFSATLSQDPEKLQDLRLFQPRLFATVLTMPVLKDATEEGADTEALT 404
              ..||.|     :...:|.||||::...:|.|:.|..|      :::.||..:.::....|..:
  Rat   282 --VNAECQ-----KRQNVLLSATLTEGVTRLADISLHNP------VSISVLDKSWDQPNPKEVAS 333

  Fly   405 DPGQFVGRYTTPAELTEQYCV---TELRLKPLTVFALVEKYKWKR-------------------- 446
            ..   :..:..|..| :||.|   ::|||..|..| :::|.|:::
  Rat   334 IQ---LDSFAIPESL-DQYVVLVPSKLRLVCLAAF-ILKKCKFEKDQKMIVFFSSCELVEFHYNL 393

  Fly   447 ----FLCF--TNSSDQATRLTFVLKVLFQKYSTKVSELSGNLSAKVRNERLRDFAAGKINGLICS 505
                .||.  |.:|:.....::.||.|         .|.||:..:.|.....:|:......|:|:
  Rat   394 FLHTLLCHSGTPASETLPSASWPLKFL---------RLHGNMKQEERTSVFHEFSHSGTGVLLCT 449

  Fly   506 DALARGIDVADVDVVLSYETPRHITTYIHRVGRTARAGRKGTAVTVLTEQDMTLFKKILSDANKG 570
            |..:||:|:..|..::.|..|.....||||:|||||.|..|:::.:|...:......:.|
  Rat   450 DVASRGLDLPQVTWIVQYSAPSAPAEYIHRIGRTARIGCHGSSLLILAPSEAEYVNSLAS----- 509

  Fly   571 LGEEIHVSPDIEIQHAVEYKEALAGLRSEKVKNKNQKMAEKNRVATKALIHKKQEETATVRPLTL 635
              .:|:||       .::.:..||.|..:....:.|:.|:::.......|    .|.|||
  Rat   510 --HKINVS-------EIKLEGILAVLAKDDCFKRRQRGAQRSHATGPQEI----RERATV----- 556

  Fly   636 MEKLQIKANEIVQSSKK----SSETKNSKTKADKTKYQPKETK 674
               ||....:.|.||::    :.:...|..:|..|  .|||.|
  Rat   557 ---LQTVFEDYVHSSQRMVSWAKKALQSFIRAYAT--YPKELK 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dbp73D	NP_476833.1	PRK11192	149..629	CDD:236877	140/516 (27%)
		DEAD	162..370	CDD:278688	76/214 (36%)
		HELICc	418..551	CDD:238034	43/161 (27%)
Ddx31	NP_001101294.2	SrmB	101..635	CDD:223587	160/582 (27%)
		DEADc	105..317	CDD:238167	84/257 (33%)
		HELICc	347..495	CDD:238034	42/157 (27%)
		DUF4217	557..618	CDD:290667	12/40 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920