DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dbp73D and SPCC285.03

DIOPT Version :9

Sequence 1:	NP_476833.1	Gene:	Dbp73D / 39871	FlyBaseID:	FBgn0004556	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_588332.1	Gene:	SPCC285.03 / 2538809	PomBaseID:	SPCC285.03	Length:	604	Species:	Schizosaccharomyces pombe

Alignment Length:	616	Identity:	197/616 - (31%)
Similarity:	303/616 - (49%)	Gaps:	87/616 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KLLKKAAKRKRK--------HEAIEVVETPILEKET--SDVKESESKEEQVEEPEKPLEV----- 81
            |:.||:.:.|||        |..........|:|..  |...:...|:.:.|:.|:.:|:
pombe    14 KIEKKSKRNKRKWLNDENKTHVTASEAAIERLKKSASFSQAAQQALKQSRKEDNERDIEMQDVDA 78

  Fly    82 -VQEEDV-----PSNEFQVLGGDDSAAKKKKVQMQLPNWLAHPTIIEGGSLQPEEEVPASEAIDQ 140
             .|..|:     ||.|..|    ||....|.:...||.|||.|..::     |...|..|    .
pombe    79 EAQPHDLLPIPQPSVEDFV----DSKPHVKNITSVLPKWLAEPITVD-----PNTTVEFS----S 130

  Fly   141 LDYLEKYTCQALKQMKIKRLFPVQKQVIPWILEAHAKPPPFR-PRDICVSAPTGSGKTLAFAIPI 204
            |:...|.. :.|::..|.|.|.||..|:|.:|:.....|.:. ..|:||||.|||||||::.|||
pombe   131 LNISSKLV-ERLQKQNITRGFAVQAAVLPLLLQDGRHGPMYSYGGDVCVSAATGSGKTLSYVIPI 194

  Fly   205 VQLLSQRVDCKVRALVVLPVAELALQVYRVISELCSKTELEVCLLSKQHKLEDEQEKLVEQYKG- 268
            ||.||.|...::|.:|::|..||.:||.:......|...|:||..:.|..|..|    ..|..|
pombe   195 VQCLSHRTVPRLRCVVIVPTRELTVQVAKTFEYYMSGAGLQVCAWTGQKSLRHE----TYQLNGD 255

  Fly   269 KYYSKADIVVTTPGRLVDHLHATKGFCLKSLKFLVIDEADRIMDAVFQNWLYHLDSHVKETT--- 330
            :...:.|::|:||||||||:...:.|.|:.|:::|||||||::|..||:|   :|:.:.|.:
pombe   256 ENECRIDVLVSTPGRLVDHIRNDESFSLQHLRYMVIDEADRLLDQSFQDW---VDTVMMEISHPK 317

  Fly   331 -----------DQLLAGTQAPLCYAELQASFGKQPHKLLFSATLSQDPEKLQDLRLFQPRLFATV 384
                       ||.::.|..|.....|.........||:|||||::||.|:..|:|..|||   |
pombe   318 CLQNKSNILDLDQNISPTFLPDIDTLLPYRLPSPLQKLVFSATLTRDPSKIASLKLHNPRL---V 379

  Fly   385 LTMPVLKD-ATEEGADTE--ALTDPGQFVGRYTTPAELTEQYCVTELRLKPLTVFALVEKYKWKR 446
            |...  || ..::|.:.|  |:.        ::.|..| ::|.|:....||:.::.|:.......
pombe   380 LVQN--KDMEVDDGGEIEDDAIV--------FSVPPTL-QEYHVSVSSEKPILLYHLIHSKNLTN 433

  Fly   447 FLCFTNSSDQATRLTFVLKVLFQKYSTKVS--ELSGNLSAKVRNERLRDFAAGKINGLICSDALA 509
            .|||..|::.|.||..:|:::.:..:...|  ..:.:||...|.:.:..||.|.:|.|:|||.:|
pombe   434 ILCFVKSNEAAARLHRLLELIHESLNQSFSCGLFTSSLSRDERKKIISRFATGDLNLLVCSDLMA 498

  Fly   510 RGIDVADVDVVLSYETPRHITTYIHRVGRTARAGRKGTAVTVLTEQDMTLFKKILSDANKGLG-- 572
            ||||||:...|::|:.|..:.:|:||:||||||||:|.|.|::...:...|.|::....:.|.
pombe   499 RGIDVANTQNVINYDPPLSVRSYVHRIGRTARAGREGFAWTLVQSHEGHHFSKLVKQLRRTLPIK 563

  Fly   573 ----EEIHVSPDIEIQHAVEYKEALAGLRSE 599
                |..|:|.:.    .|.|.:||..||.|
pombe   564 RIKIEFSHISEEF----VVAYDKALEALRVE 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dbp73D	NP_476833.1	PRK11192	149..629	CDD:236877	163/478 (34%)
		DEAD	162..370	CDD:278688	82/223 (37%)
		HELICc	418..551	CDD:238034	49/134 (37%)
SPCC285.03	NP_588332.1	PRK01297	45..535	CDD:234938	174/524 (33%)
		P-loop_NTPase	128..380	CDD:304359	95/266 (36%)
		Helicase_C	416..532	CDD:278689	41/115 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	128	1.000	Domainoid score	I1354
eggNOG	1	0.900	-	-		E2759_KOG0350
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	247	1.000	Inparanoid score	I795
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005234
OrthoInspector	1	1.000	-	-		oto100643
orthoMCL	1	0.900	-	-		OOG6_103754
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R292
SonicParanoid	1	1.000	-	-		X3754
TreeFam	1	0.960	-	-
	12	11.850