DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dbp73D and Ddx31

DIOPT Version :9

Sequence 1:	NP_476833.1	Gene:	Dbp73D / 39871	FlyBaseID:	FBgn0004556	Length:	687	Species:	Drosophila melanogaster
Sequence 2:	NP_001028466.2	Gene:	Ddx31 / 227674	MGIID:	2682639	Length:	687	Species:	Mus musculus

Alignment Length:	693	Identity:	184/693 - (26%)
Similarity:	303/693 - (43%)	Gaps:	154/693 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KKAAKRKRKHEAIEVVETP----------ILEKETSDVKESE----SKEEQVEEPEKPLEVV--- 82
            ::|...||||:...  :.|          :|.|:.|| ||::    ....:...|:|.|:.:
Mouse     3 RQAEATKRKHQVSS--DAPPAKRRSEISSVLAKKASD-KETQRTFKGSTHKTFPPKKYLDSIGNG 64

  Fly    83 QEEDVP----SNEFQVLGGDDSAAKKKKVQMQLPNWLAHPTIIEGGSLQPEEEVPASEAIDQLDY 143
            ::|:.|    |:.|             |...::|.  .|.|:::    |..|:|.:.||..:||
Mouse    65 RQEEKPCIKTSSLF-------------KNNPEIPE--LHSTVVK----QAREQVFSPEAFQELD- 109

  Fly   144 LEKYTCQALKQ-MKIKRLFPVQKQVIPWILEAHAKPPPFRPRDICVSAPTGSGKTLAFAIPIVQL 207
            |..:....:.. :|:..:..||||.||.:||.         ||..|.:.||||||||:.:|:||.
Mouse   110 LHPHLISTINTVLKMSSMTSVQKQSIPVLLEG---------RDALVRSQTGSGKTLAYCVPVVQS 165

  Fly   208 LSQRVDCKVR------ALVVLPVAELALQVYRVISELCSK-TELEVCLLSKQHKLEDEQEKLVEQ 265
            | |.:..|::      |||::|..|||||.:..:.:|... |.:...:|....|.:.|:.:|
Mouse   166 L-QALTSKIQRSDGPYALVLVPTRELALQSFDTVQKLLKPFTWIVPGVLMGGEKRKSEKARL--- 226

  Fly   266 YKGKYYSKADIVVTTPGRLVDHLHATKGFCLKSLKFLVIDEADRIMDAVFQNWLYHLDSHVKETT 330
            .||     .:|:::||||||||:.:||......:::|::||||||:|..|:          |:.|
Mouse   227 RKG-----INILISTPGRLVDHIKSTKNLHFNRIRWLIVDEADRILDLGFE----------KDIT 276

  Fly   331 DQLLAGTQAPLCYAELQASFGKQPHKLLFSATLSQDPEKLQDLRLFQPRLFAT------------ 383
            ..|.|      ..||.|     :...:|.||||::...:|.|:.|..|...:.
Mouse   277 VILNA------VNAECQ-----KRQNVLLSATLTEGVTRLVDISLHNPVSISVLDKNCNQPNPKE 330

  Fly   384 VLTMPVLKDATEEGADTEALTDPGQFVGRYTTPAELTEQYCVTELRLKPLTVFALVE--KYKWKR 446
            |.::.:...|..|..|...:..|.:.  |....|....|.|..|...|.:..|:..|  ::.:..
Mouse   331 VASIQLNSFAIPESLDQHVVLVPSKL--RLVCLAAFILQKCKFEKNQKMIVFFSSCELVEFHYSL 393

  Fly   447 F----LCF--TNSSDQATRLTFVLKVLFQKYSTKVSELSGNLSAKVRNERLRDFAAGKINGLICS 505
            |    ||.  |.:|:.....::.||.|         .|.||:..:.|.....:|:..:...|:|:
Mouse   394 FLHTLLCHSGTPTSEHLPSASWPLKFL---------RLHGNMEQEERTSVFHEFSHSETGVLLCT 449

  Fly   506 DALARGIDVADVDVVLSYETPRHITTYIHRVGRTARAGRKGTAVTVLTEQDMTLFKKILSDANKG 570
            |..:||:|:..|..::.|..|.....||||:|||||.|..|:::.:|...:......:.|
Mouse   450 DVASRGLDLPQVTWIVQYSAPSSPAEYIHRIGRTARIGCHGSSLLILAPSEAEYVNSLAS----- 509

  Fly   571 LGEEIHVSPDIEIQHAVEYKEALAGLRSEKVKNKNQKMAEKNRVATKALIHKKQEETATVRPLTL 635
              .:|:|.       .::.::.||.|..:....:.|:.|:|:|.:....|    .|.|||
Mouse   510 --HKINVG-------EIKMEDILAVLAKDDCFKRRQRGAQKSRASGPQEI----RERATV----- 556

  Fly   636 MEKLQIKANEIVQSSKK----SSETKNSKTKADKTKYQPKETK 674
               ||....:.|.||::    :.:...|..:|..|  .|||.|
Mouse   557 ---LQTVFEDYVHSSQRMVSWAKKALQSFIRAYAT--YPKELK 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dbp73D	NP_476833.1	PRK11192	149..629	CDD:236877	138/507 (27%)
		DEAD	162..370	CDD:278688	74/214 (35%)
		HELICc	418..551	CDD:238034	39/140 (28%)
Ddx31	NP_001028466.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63		15/62 (24%)
		Q motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00552	103..132		7/29 (24%)
		PRK04837	105..553	CDD:235314	140/516 (27%)
		P-loop_NTPase	105..317	CDD:304359	82/251 (33%)
		DEAD box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	261..264		2/2 (100%)
		HELICc	347..495	CDD:238034	42/158 (27%)
		DUF4217	557..618	CDD:290667	12/40 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	625..687
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D973872at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920