DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dab and MAPK8IP1

DIOPT Version :10

Sequence 1:NP_001163455.2 Gene:Dab / 39866 FlyBaseID:FBgn0000414 Length:2360 Species:Drosophila melanogaster
Sequence 2:NP_005447.1 Gene:MAPK8IP1 / 9479 HGNCID:6882 Length:711 Species:Homo sapiens


Alignment Length:846 Identity:163/846 - (19%)
Similarity:242/846 - (28%) Gaps:314/846 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  1194 DEFNEDHDLRQIMDHQNVQTHARDRHGLVDSRGFPTEPSSSALTVGDYDEDEDADAGGESSLDSN 1258
            :|| ||.||.:|.|...:....:|...|       ..|.:..|:.|         .||..|    
Human    42 EEF-EDEDLSEITDECGISLQCKDTLSL-------RPPRAGLLSAG---------GGGAGS---- 85

  Fly  1259 EKDAEPVSGQDQYEKLSTSTQQLDAAAPALEDVQQLQQQSLPPKQDQKFLSILTAPGG--GTKDD 1321
                          :|.....|:|                           ::.|.|.  |.:||
Human    86 --------------RLQAEMLQMD---------------------------LIDATGDTPGAEDD 109

  Fly  1322 IEIDELMHRAISNLSLDSRDRVSPATSSAAPSRGAPGLHTPSQFNDVSTSPIPLQKPGMGPSPVP 1386
            .|.|:           :.|....|   .|.|.:...|....|:....|..  ..|.||.|.:..|
Human   110 EEDDD-----------EERAARRP---GAGPPKAESGQEPASRGQGQSQG--QSQGPGSGDTYRP 158

  Fly  1387 SQ------LSAVSQLIDTATKQMMGDKDREKQSW----ATFDSPKAKGKARL---------TLPP 1432
            .:      ...|.:..||.....:|    :|.||    :...||...|:...         .|||
Human   159 KRPTTLNLFPQVPRSQDTLNNNSLG----KKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPP 219

  Fly  1433 PPPPASNTSQPDTVESPCSSDPRDDGWSKQQRRWAKKERQQTSSSSRDLSPWDDETPEYLKRRQL 1497
            ...||..|.:..:.:|||                                            |:.
Human   220 QSGPAPTTDRGTSTDSPC--------------------------------------------RRS 240

  Fly  1498 AAAQMAHPHQPPMQAPP-----QHTDRHGYYMRHARRMNSCDEDYDYDGEFVARRDQPQHQQQQR 1557
            .|.|||.|..|| .|||     .|.||..|  :...|:.:.:|.|     ....:..|...:...
Human   241 TATQMAPPGGPP-AAPPGGRGHSHRDRIHY--QADVRLEATEEIY-----LTPVQRPPDAAEPTS 297

  Fly  1558 KF----KHGLSRSRDNFELESPSWYHHPAHHTWSPQEIEQVRVRSFDRTAYE----------RSS 1608
            .|    :..:|.|.|......||....| |.:.|.:|      ..||..:..          |.|
Human   298 AFLPPTESRMSVSSDPDPAAYPSTAGRP-HPSISEEE------EGFDCLSSPERAEPPGGGWRGS 355

  Fly  1609 YGPPPP----------------------IYDKRGQ-----LRGKYRGDHRDRERERDRDREYRDY 1646
            .|.|||                      :.|:..|     ||..: ||:.|   |.|....|.:.
Human   356 LGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCF-GDYSD---ESDSATVYDNC 416

  Fly  1647 ARPSYDFDYENVYEERGGRSPLAYKPGRGGGDYLYDRERDRDRERDRKSFDRESLESYESATRR- 1710
            |  |....||:...|....:|....|.....|...|       |.| ..|.::.|..:.|...| 
Human   417 A--SVSSPYESAIGEEYEEAPRPQPPACLSEDSTPD-------EPD-VHFSKKFLNVFMSGRSRS 471

  Fly  1711 --RRSFGSGNDVYGSLDSRDDYRG-DRERDRERDREQMKTRSLRKPTTTSGKLRISGDIDYEQDS 1772
              ..|||..:.:....:....:|. .|...|..|..:               |.:...:..|..:
Human   472 SSAESFGLFSCIINGEEQEQTHRAIFRFVPRHEDELE---------------LEVDDPLLVELQA 521

  Fly  1773 E----QDFQQRSGVRSLQRPNQLGGDVVLPSNAVV----GPQRLRKSSGSSPWDGE-------EP 1822
            |    :.:..|:|.|.           |.|:...:    .|:.:...:.:|.|..:       ..
Human   522 EDYWYEAYNMRTGARG-----------VFPAYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSV 575

  Fly  1823 ALPGQKSWKRPASAAE---TERRLAE------------SRRAVALGQTPSDGEKERRFRKKTRAR 1872
            .:|..|......:|.:   |.|||..            |.|.|.:| ..:|..:|.:..|.:...
Human   576 QVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIG-VKADDSQEAKGNKCSHFF 639

  Fly  1873 SAKDLATVG--------------------------APSASTSAPSRSSYGRGIRDNY----DYIC 1907
            ..|:::..|                          ....||.|.: .|.||..:..|    :|.|
Human   640 QLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALA-ESVGRAFQQFYKQFVEYTC 703

  Fly  1908 P 1908
            |
Human   704 P 704

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DabNP_001163455.2 PTB_Dab 35..181 CDD:269926
PRK12727 542..>708 CDD:237182
MAPK8IP1NP_005447.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..27
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 78..371 82/425 (19%)
JNK-binding domain (JBD) 127..285 45/215 (21%)
Minimal inhibitory domain (MID) 157..176 2/18 (11%)
Interaction with MAP3K7. /evidence=ECO:0000269|PubMed:17709393 283..471 43/208 (21%)
D-box 1 353..360 3/6 (50%)
D-box 2 364..372 0/7 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..451 5/28 (18%)
Interaction with VRK2. /evidence=ECO:0000269|PubMed:18286207 471..660 34/215 (16%)
SH3_JIP1 492..546 CDD:212876 12/79 (15%)
PTB_JIP 563..711 CDD:269923 27/144 (19%)
Blue background indicates that the domain is not in the aligned region.

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