DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dab and MAPK8IP1

DIOPT Version :9

Sequence 1:	NP_001163455.2	Gene:	Dab / 39866	FlyBaseID:	FBgn0000414	Length:	2360	Species:	Drosophila melanogaster
Sequence 2:	NP_005447.1	Gene:	MAPK8IP1 / 9479	HGNCID:	6882	Length:	711	Species:	Homo sapiens

Alignment Length:	846	Identity:	163/846 - (19%)
Similarity:	242/846 - (28%)	Gaps:	314/846 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1194 DEFNEDHDLRQIMDHQNVQTHARDRHGLVDSRGFPTEPSSSALTVGDYDEDEDADAGGESSLDSN 1258
            :|| ||.||.:|.|...:....:|...|       ..|.:..|:.|         .||..|
Human    42 EEF-EDEDLSEITDECGISLQCKDTLSL-------RPPRAGLLSAG---------GGGAGS---- 85

  Fly  1259 EKDAEPVSGQDQYEKLSTSTQQLDAAAPALEDVQQLQQQSLPPKQDQKFLSILTAPGG--GTKDD 1321
                          :|.....|:|                           ::.|.|.  |.:||
Human    86 --------------RLQAEMLQMD---------------------------LIDATGDTPGAEDD 109

  Fly  1322 IEIDELMHRAISNLSLDSRDRVSPATSSAAPSRGAPGLHTPSQFNDVSTSPIPLQKPGMGPSPVP 1386
            .|.|:           :.|....|   .|.|.:...|....|:....|..  ..|.||.|.:..|
Human   110 EEDDD-----------EERAARRP---GAGPPKAESGQEPASRGQGQSQG--QSQGPGSGDTYRP 158

  Fly  1387 SQ------LSAVSQLIDTATKQMMGDKDREKQSW----ATFDSPKAKGKARL---------TLPP 1432
            .:      ...|.:..||.....:|    :|.||    :...||...|:...         .|||
Human   159 KRPTTLNLFPQVPRSQDTLNNNSLG----KKHSWQDRVSRSSSPLKTGEQTPPHEHICLSDELPP 219

  Fly  1433 PPPPASNTSQPDTVESPCSSDPRDDGWSKQQRRWAKKERQQTSSSSRDLSPWDDETPEYLKRRQL 1497
            ...||..|.:..:.:|||                                            |:.
Human   220 QSGPAPTTDRGTSTDSPC--------------------------------------------RRS 240

  Fly  1498 AAAQMAHPHQPPMQAPP-----QHTDRHGYYMRHARRMNSCDEDYDYDGEFVARRDQPQHQQQQR 1557
            .|.|||.|..|| .|||     .|.||..|  :...|:.:.:|.|     ....:..|...:...
Human   241 TATQMAPPGGPP-AAPPGGRGHSHRDRIHY--QADVRLEATEEIY-----LTPVQRPPDAAEPTS 297

  Fly  1558 KF----KHGLSRSRDNFELESPSWYHHPAHHTWSPQEIEQVRVRSFDRTAYE----------RSS 1608
            .|    :..:|.|.|......||....| |.:.|.:|      ..||..:..          |.|
Human   298 AFLPPTESRMSVSSDPDPAAYPSTAGRP-HPSISEEE------EGFDCLSSPERAEPPGGGWRGS 355

  Fly  1609 YGPPPP----------------------IYDKRGQ-----LRGKYRGDHRDRERERDRDREYRDY 1646
            .|.|||                      :.|:..|     ||..: ||:.|   |.|....|.:.
Human   356 LGEPPPPPRASLSSDTSALSYDSVKYTLVVDEHAQLELVSLRPCF-GDYSD---ESDSATVYDNC 416

  Fly  1647 ARPSYDFDYENVYEERGGRSPLAYKPGRGGGDYLYDRERDRDRERDRKSFDRESLESYESATRR- 1710
            |  |....||:...|....:|....|.....|...|       |.| ..|.::.|..:.|...|
Human   417 A--SVSSPYESAIGEEYEEAPRPQPPACLSEDSTPD-------EPD-VHFSKKFLNVFMSGRSRS 471

  Fly  1711 --RRSFGSGNDVYGSLDSRDDYRG-DRERDRERDREQMKTRSLRKPTTTSGKLRISGDIDYEQDS 1772
              ..|||..:.:....:....:|. .|...|..|..:               |.:...:..|..:
Human   472 SSAESFGLFSCIINGEEQEQTHRAIFRFVPRHEDELE---------------LEVDDPLLVELQA 521

  Fly  1773 E----QDFQQRSGVRSLQRPNQLGGDVVLPSNAVV----GPQRLRKSSGSSPWDGE-------EP 1822
            |    :.:..|:|.|.           |.|:...:    .|:.:...:.:|.|..:       ..
Human   522 EDYWYEAYNMRTGARG-----------VFPAYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSV 575

  Fly  1823 ALPGQKSWKRPASAAE---TERRLAE------------SRRAVALGQTPSDGEKERRFRKKTRAR 1872
            .:|..|......:|.:   |.|||..            |.|.|.:| ..:|..:|.:..|.:...
Human   576 QVPYHKGNDVLCAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIG-VKADDSQEAKGNKCSHFF 639

  Fly  1873 SAKDLATVG--------------------------APSASTSAPSRSSYGRGIRDNY----DYIC 1907
            ..|:::..|                          ....||.|.: .|.||..:..|    :|.|
Human   640 QLKNISFCGYHPKNNKYFGFITKHPADHRFACHVFVSEDSTKALA-ESVGRAFQQFYKQFVEYTC 703

  Fly  1908 P 1908
            |
Human   704 P 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926
MAPK8IP1	NP_005447.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..371		82/425 (19%)
		JNK-binding domain (JBD)	127..285		45/215 (21%)
		Minimal inhibitory domain (MID)	157..176		2/18 (11%)
		Interaction with MAP3K7. /evidence=ECO:0000269\|PubMed:17709393	283..471		43/208 (21%)
		D-box 1	353..360		3/6 (50%)
		D-box 2	364..372		0/7 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..451		5/28 (18%)
		Interaction with VRK2. /evidence=ECO:0000269\|PubMed:18286207	471..660		34/215 (16%)
		SH3_JIP1	492..546	CDD:212876	12/79 (15%)
		PTB_JIP	563..711	CDD:269923	27/144 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141128
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840