DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dab and NUMBL

DIOPT Version :9

Sequence 1:	NP_001163455.2	Gene:	Dab / 39866	FlyBaseID:	FBgn0000414	Length:	2360	Species:	Drosophila melanogaster
Sequence 2:	NP_004747.1	Gene:	NUMBL / 9253	HGNCID:	8061	Length:	609	Species:	Homo sapiens

Alignment Length:	707	Identity:	147/707 - (20%)
Similarity:	220/707 - (31%)	Gaps:	246/707 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 FKAKLIGILEVGEARGDRMCQEALQDLKMAIRAAGEHKQRITIHVTIDGLRLRDEKTGDSLYHHP 115
            |..:.:|.:||.|:||..:|::|::.||    |.|....:..:.|:.||||:.|:||.|.|....
Human    80 FPVRYLGHVEVEESRGMHVCEDAVKKLK----AMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQT 140

  Fly   116 VHKISFIAQDMTDSRAFGYIFGSPDSG----HRFFGIKTDKAASQVVLAMRDLFQVVFELKKKEI 176
            :.|:||.|.|....:||.||.....:.    |.|..:|  .:..::..|:...|....|
Human   141 IEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALK--DSGERLSHAVGCAFAACLE------ 197

  Fly   177 EMARQQIQGKSLHDHSSQLASLSSLKSSGLGGMGLGHSDLASGGISSGHALTLLGSSLSTTNGTS 241
               |:|.:.|.....::..||.:|....|        |...|||                  |..
Human   198 ---RKQRREKECGVTAAFDASRTSFAREG--------SFRLSGG------------------GRP 233

  Fly   242 RLGVSLDVAKASGSAAKEVSPESVADLVDLEQELTSLQRGISQMERITPNEPTTS--STGGAGHP 304
            ....:.|..||..:||..|:|                  |.:|...::|...|||  ..|.||.|
Human   234 AEREAPDKKKAEAAAAPTVAP------------------GPAQPGHVSPTPATTSPGEKGEAGTP 280

  Fly   305 SLAKSASEDDP----------FGDSFIYVPSYSILPPP------------PDSGRNR-------- 339
            ..|.:.:...|          ...||...|:.|....|            |.:.:.|
Human   281 VAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGT 345

  Fly   340 ---HKPPNK-TPDAVTSLDAMLS------------PPPGT--SSSHGSASA--------GLQAAD 378
               .:||.. ..|::.:|...:|            |||.|  :|:.|..|.        |.:...
Human   346 VPEMEPPGAGDSDSINALCTQISSSFASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTP 410

  Fly   379 NDDDNWLQELDQQNDVFDTSKVVSSSGLGSVLAMAPLASSESTATPTQQLTEVAAGSGPLADLDI 443
            ::.:.||:|:.|      .:|           |.......:......||..:.||...|:..:..
Human   411 SEAERWLEEVSQ------VAK-----------AQQQQQQQQQQQQQQQQQQQQAASVAPVPTMPP 458

  Fly   444 GLSTALGNEEQTSTILSLDAFTDLDPLGTGRTRPYVDKKYFFQELKNPPKKLLKELSSGSQAGLG 508
            .|.....                  |:|.....|.....:.......||       ...:..|||
Human   459 ALQPFPA------------------PVGPFDAAPAQVAVFLPPPHMQPP-------FVPAYPGLG 498

  Fly   509 LGLSLGQLDGLFPEDSTTISTTTTTATNITAGNPQQNSANTLTSTASTAASLGQLLSTVALNPDP 573
                       :|      .........||   |.|..||...|.|........||......|.|
Human   499 -----------YP------PMPRVPVVGIT---PSQMVANAFCSAAQLQPQPATLLGKAGAFPPP 543

  Fly   574 LPAPISIPTSISHSITPSAELKLLLGHVTNPPNPTGHYYTTEPPTLNSLENPHPPADPVLLPRDT 638
                 :||::      |.::.:         |.|.|..:   ||      .|.|...|.|
Human   544 -----AIPSA------PGSQAR---------PRPNGAPW---PP------EPAPAPAPEL----- 574

  Fly   639 DPFSPTRKKSDPDPFQESDLFAKLDAFEFEAPPAVPAPSIPNLATETKANVFNGPLQ 695
                        |||:     |:..|.|.:|            ..|..:|.|:|.||
Human   575 ------------DPFE-----AQWAALEGKA------------TVEKPSNPFSGDLQ 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926	38/133 (29%)
NUMBL	NP_004747.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68
		PTB_Numb	64..198	CDD:241298	38/132 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	223..283		23/103 (22%)
		NumbF	287..371	CDD:283874	13/83 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..421		11/48 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	434..464		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..609		27/129 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141149
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840