DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dab and Dab2

DIOPT Version :9

Sequence 1:	NP_001163455.2	Gene:	Dab / 39866	FlyBaseID:	FBgn0000414	Length:	2360	Species:	Drosophila melanogaster
Sequence 2:	NP_077073.1	Gene:	Dab2 / 79128	RGDID:	621007	Length:	768	Species:	Rattus norvegicus

Alignment Length:	895	Identity:	218/895 - (24%)
Similarity:	348/895 - (38%)	Gaps:	259/895 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RFFGDGVQFKAKLIGILEVGEARGDRMCQEALQDLK---MAIRAAGEHKQRITIHVTIDGLRLRD 104
            ||.||||::|||||||.:|.:||||:|.|:::..||   .|.|:.|:|||||.:::::.|:::.|
  Rat    42 RFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIID 106

  Fly   105 EKTGDSLYHHPVHKISFIAQDMTDSRAFGYIFGSPDSGHRFFGIKTDKAASQVVLAMRDLFQVVF 169
            ||||...:.|||:||||||:|:||:|||||:.|. :..|:||.|||.:.|..:|:.::|||||::
  Rat   107 EKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGG-EGQHQFFAIKTGQQAEPLVVDLKDLFQVIY 170

  Fly   170 ELKKKEIEMARQQIQGKSLHDHSSQLASL----SSLKSSGLGGMGLGHSDLASGGISSGHALTLL 230
            .:||||.|..:.:...|:..:.|..|.:|    :.||      :|:...||.
  Rat   171 NVKKKEEEKKKVEEANKAEENGSEALMTLDDQANKLK------LGVDQMDLF------------- 216

  Fly   231 GSSLSTTNGTSRLGVSLDVAKASGSAAKEVSPESVADLVDLEQELTSLQRGISQMERITPNEPTT 295
             ..:||....:....|.|:.                 ||||..|:.:.|..:.:...:| |..|:
  Rat   217 -GDMSTPPDLNNPTESRDIL-----------------LVDLNSEIDTNQNSLRENPFLT-NGVTS 262

  Fly   296 SSTGGAGHPSLAKSASEDDPFGDSFIYVPSYSILPPPPDSGRNRHKPPNKTPD--------AVTS 352
            .|   ...|....|...:..|..:..:.|:     |.||..|:   .|...||        ::||
  Rat   263 CS---LPRPKPQASFLPESAFSANLNFFPT-----PNPDPFRD---DPFAQPDQSAPSSFHSLTS 316

  Fly   353 LDAMLSPPPGTSSSHGSASAGLQAADNDDDNWLQELDQQNDVFDTSKVVSSSGLGSVLAMAPLAS 417
            .|...:.|...|:.....     ..:.|.|.:.|:.||.::  .|.|..:..|      ..|..|
  Rat   317 ADQKKANPGSLSTPQSKG-----PLNGDTDYFGQQFDQISN--RTGKQEAQGG------PWPYPS 368

  Fly   418 SESTATPTQQLTEVAAGSGPLADLDIGLSTALGNEEQTSTILSLDAFTDLDPLGTGRTRPYVDKK 482
            |:     |||......|              :..:||....:.            ....|:|.
  Rat   369 SQ-----TQQAVRTQNG--------------VSEKEQNGFHIK------------SSPNPFVG-- 400

  Fly   483 YFFQELKNPPKKL------LKELSSGSQAGLGLGLSLGQLDGLFPEDSTTIS----TTTTTATNI 537
                   :|||.|      .::|.|..|:.....:::     :.|..||...    |..::|.::
  Rat   401 -------SPPKGLSVPNGVKQDLESSVQSSAHDSIAI-----IPPPQSTKPGRGRRTAKSSANDL 453

  Fly   538 TAGN------------------PQQNSANTLTSTASTAASLGQL--LSTVALNPDPLPAP-ISIP 581
            .|.:                  ||.|..:...::|......|.|  |.||.:.| |...| ..:.
  Rat   454 LASDIFASEPPGQMSPTGQPAVPQANFMDLFKTSAPAPMGSGPLVGLGTVPVTP-PQAGPWTPVV 517

  Fly   582 TSISHSITPSAELKLLLGHVTNPPNPTGH---YYTT-------EPPTLNSLENPHPPADPVLLPR 636
            .:.|.::.|.|       .::..|:..|.   :.||       :|.:..:..:|.|||  |..|
  Rat   518 FTPSTTVVPGA-------IISGQPSGFGQPLVFGTTPAVQVWNQPSSFATAASPPPPA--VWCP- 572

  Fly   637 DTDPFSP-TRKKSDP--DPFQESDLFAKLDAFEFEAPPAV------PAPSIPN-LATETKANVFN 691
             |...:| |...:.|  :|||.|::|          ||:.      |.|.:.: |.|..:....|
  Rat   573 -TTSVAPNTWSSTSPLGNPFQSSNIF----------PPSTISTQSFPQPMMSSVLVTPPQPPPRN 626

  Fly   692 GPLQVQLPPE-------------------KELQLQQPPSTVRNRPTASVSALPSGGALDVISSIS 737
            |||:..|...                   |:.||:|||.....:     ...||.|.....||..
  Rat   627 GPLKDTLSDAFTGLDPLGDKEVKEVKEMFKDFQLRQPPLVPSRK-----GETPSSGTSSAFSSYF 686

  Fly   738 NKKM----PHLFGQARSFGKSGSDIGSSVNMRRLQESDSLSETEAAPEPPPRPDSTPYSEPPPLP 798
            |.|:    .|:         ...|..::..:.::.|         .|:|.||......::
  Rat   687 NNKVGIPQEHV---------DHDDFDANQLLNKINE---------PPKPAPRQGVLSGTK----- 728

  Fly   799 PKKQFSDLVIRPSPANTTQPPTSGRYEYLNSNVTARRTASSVDAPPIPLP 848
                        |..|:.:.|.|..:...|.:|.::..:|.....|...|
  Rat   729 ------------SADNSLENPFSKGFSSTNPSVVSQPASSDAHRSPFGNP 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926	72/140 (51%)
Dab2	NP_077073.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		PTB_Dab	35..171	CDD:269926	67/129 (52%)
		Required for localization to clathrin-coated pits. /evidence=ECO:0000250	230..447		58/303 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..449		43/229 (19%)
		DPF 1	293..295		1/1 (100%)
		DPF 2	298..300		0/1 (0%)
		Sufficient for interaction with GRB2. /evidence=ECO:0000250	601..731		30/169 (18%)
		Required for interaction with CSK	619..627		0/7 (0%)
		Required for interaction with MYO6. /evidence=ECO:0000250	649..768		29/158 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	660..682		7/26 (27%)
		Required for interaction with GRB2 and CSK. /evidence=ECO:0000269\|PubMed:12473651	663..671		2/12 (17%)
		Sufficient for interaction with SH3KBP1 SH3 domain. /evidence=ECO:0000250	708..724		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..768		14/84 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334827
Domainoid	1	1.000	109	1.000	Domainoid score	I6225
eggNOG	1	0.900	-	-		E1_KOG3535
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002247
OrthoInspector	1	1.000	-	-		otm45486
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11232
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.890