Protein Alignment Dab and mapk8ip2

DIOPT Version :9

• Sequence 1: NP_001163455.2
• Gene: Dab / 39866
• FlyBaseID: FBgn0000414
• Length: 2360
• Species: Drosophila melanogaster
• Sequence 2: XP_685086.6
• Gene: mapk8ip2 / 561262
• ZFINID: ZDB-GENE-070705-326
• Length: 1242
• Species: Danio rerio
• Alignment Length: 1357
• Identity: 262/1357 - (19%)
• Similarity: 413/1357 - (30%)
• Gaps: 516/1357 - (38%)

  Fly   769 ESDSLSETEAAPEPPPRPDSTPYSEPPPLPPKKQFSDLVIRPSPANTTQPPTSGRYEYLNSNVTA 833
            |.|...|.||.|:.||.|.::|       ||......|..||:..|.|.|.:...... ||||:.
Zfish    89 EDDEEEEEEADPDAPPSPSASP-------PPSPTLGTLKSRPTTLNLTVPVSQDSLNN-NSNVSP 145

  Fly   834 RRTASSVDAPPIPLPSRRVGRSDGCFPGPGRPRKPGHT--EDDYLAPLGAPPPLLPPPSQGSSAR 896
            |:::..        .|.|...|.||.       .|.|:  ||.  :.:.|..|:.|...  .||:
Zfish   146 RKSSWQ--------DSLRNSTSQGCL-------SPNHSCLEDG--SHVTATCPVAPETI--GSAK 191

  Fly   897 ARPQRQA-------SLGRP--QDIYENKAE------ILQAQAQAQAQAPEVAPSSNTLAPDITLT 946
            ..|...:       |.|||  .|...|:.|      ..|..:.:.::|.||.|.    ..:.||:
Zfish   192 GTPSNPSGHCGLHQSPGRPLLYDFEGNRRERPEYGSFGQHNSSSGSEATEVKPD----VEESTLS 252

  Fly   947 QLLTLGMDDLAIKLNVPASKLSTMTLVQLTAYLSEYLSSEKSQVHSQER--RSSPANTAPAPAST 1009
            :|:. .:||                   .|:..|:.........|::.|  ||.|.:|......|
Zfish   253 ELVP-SVDD-------------------CTSQCSDTEVDHDLNGHAKRRPCRSRPNDTYTVTTET 297

  Fly  1010 AAVFKVNFDQQTSFVAKFDDTFGEDEPVMPSGSSDSTFVANFANFNDAPTPVPTVSPVVATVPSA 1074
            |                       |:|.:.:..:.....:.....|||.||
Zfish   298 A-----------------------DDPELENDGTSRCLSSTAPLGNDAETP-------------- 325

  Fly  1075 DRYAVFREIIDQELQQQQQETDLMG----DLTPPPVD-----ETQAKEISEGLEVNNVGAELPID 1130
                    :.|:|| .::.:.|.|.    |.|....:     |....|.:|.:.|::..:....|
Zfish   326 --------LSDEEL-DKEFDIDFMSKESYDQTCKDAEGSSYIEFPCIEPTESISVSSYVSSSRSD 381

  Fly  1131 ALDVKPAPKIDTKITEVVAQAKDRYAALRDIILVENLFDKPAIA-TDTQPEKEKDLLQDFPEFSD 1194
            .||....|:                          |:....|.| .||.|..:       |..:|
Zfish   382 VLDAMDEPR--------------------------NMHQGQAAAENDTSPSSD-------PGIAD 413

  Fly  1195 EFNEDHDLRQIMDHQNVQTHAR-DRHGLVDSRGFPTEPSSSALTVGDYD-EDEDADA-GGE---- 1252
                          .|.:.:|. |||         ::..||..:..|.: |.|:|.| ||.
Zfish   414 --------------MNAKRYAESDRH---------SDDLSSPGSDSDIEGELEEAFACGGPLASN 455

  Fly  1253 --SSLDSNEKDAEPVSGQDQYEKLSTSTQQLDAAAPALEDVQQLQQQSLPPKQDQKFLSILTAPG 1315
              ||:...|.|....|...:...|:.|.:  :|::|..:  |:|.|: |..:||...:.:..:..
Zfish   456 MISSISETELDLTSESSSGRSSHLTNSIE--EASSPTSD--QELDQE-LDTEQDSGIVGLKASLL 515

  Fly  1316 GGTKDDIEIDELMHRAISNLSLDSRDRVSPATSSAAPSRGAPGLHTPSQFNDVSTSPIPLQKPGM 1380
            .|..|.|:.|.|                                                  ||:
Zfish   516 LGQPDPIKQDPL--------------------------------------------------PGL 530

  Fly  1381 GPSPVPSQLSAVSQLIDTATKQMMG----DKDREKQSWATFDSPKAKGKARLTLPPPPPPASNTS 1441
            .||      |.:.||.|  .:.:||    |.:::.:..|..|.         ||||..|...::|
Zfish   531 DPS------SDMLQLDD--GQALMGLQNVDDEQDYEHQADPDE---------TLPPAIPCEDSSS 578

  Fly  1442 Q-------PD-TVES-------PCSSD--PRDDGWSKQQRRWAKKERQQTSSSSRDLSPWDDETP 1489
            |       || ::||       |....  |..|.:.......::.|.:...|.:.| |||   ..
Zfish   579 QQLLLKIEPDHSLESFKRSFYLPVGPKLMPSVDDYDGNSEGDSESESEDELSENSD-SPW---LL 639

  Fly  1490 EYLKRRQLAAAQMAHPHQPPMQAPPQHTDRHGYYMRHARRMNSCDEDYDYDGEFVARRD--QPQH 1552
            ..|..|.::....      |:..|.:      .:.|.|...::.....|.:.:.....|  ..|.
Zfish   640 SNLVNRMISEGSY------PISCPEE------CFKRSASISDTISPSSDLETDAFNETDGCNFQK 692

  Fly  1553 QQQQRKFKHGLSRSRDNFELESPSWYHHPAHHTWSPQEIEQVRVRSFDRTAYERSSYGPPPPIYD 1617
            |:.:.|.:...|.:|...|.|..:        :.:.:|.::...|:.........:||...|::.
Zfish   693 QKSEEKSQEVKSEARVVEEKEREA--------SCASEEGQKESKRTDSCLYMSNPTYGTVTPVFT 749

  Fly  1618 KRGQLRGKYRGDHRDRERERDRDREYRDYARPSYDFDYENVYEERGGRSPLAYKPGRGGGDYLYD 1682
            :|...|.|      :.|.|               ||..:|                     .|.:
Zfish   750 ERFDTRTK------NYEAE---------------DFPSQN---------------------SLKN 772

  Fly  1683 RERDRDRERDR-------KSFDRESL-ESYESATRRRRSFGSGNDVYGSLDSRDDYRGDRERDRE 1739
            :::|.:.|.:.       |..|..|| ||..|                          |::..||
Zfish   773 KQKDEEEEPNNDLMMERMKELDSPSLSESIIS--------------------------DKDEGRE 811

  Fly  1740 RDREQMKTRSLRKPTTTSGKLRIS---------GDIDYEQDSEQDFQQRSG-VRSLQR-PNQLGG 1793
            ...:|:   :|::.|.....|.:.         ..:.|..|:::|.|..|. :..|.: |:..|.
Zfish   812 TKVDQL---TLQRITEVKNSLTLDLPTAQTNHCFSLTYSTDNDEDEQDTSPFLDDLHKIPSPYGN 873

  Fly  1794 DVVLPSNAVV--GPQRLRKSSGSSPWDGEEPALPGQKSWKRPASAAE-TERRLAESRRAVALGQT 1855
            :..|.|:..:  ..:.||..:...|.|..    ....|.|......| |...|...:|..::...
Zfish   874 ETYLDSSPPIDESVRELRNRTSDRPIDDS----LAYDSMKYTLVVDENTTLELVSLKRCTSVLSE 934

  Fly  1856 PSDGEKERRFRKKTRARSAKDLATVGAPSASTSAPSRSSYGRGIRDNYDYICPGQRNDDD--DDD 1918
            .|||                 |:|                          ||     |||  |:|
Zfish   935 DSDG-----------------LST--------------------------IC-----DDDVADED 951

  Fly  1919 DEDYVDDEPPTDEDKFERLNRRRHEMHQRMLESERRQMERHQPPSL------------AKLPGQN 1971
            |:.|                             .|.||.|...|:|            |.||...
Zfish   952 DDIY-----------------------------GRGQMVRGMRPNLLLSSSEEDSSPEADLPFSK 987

  Fly  1972 RTRGVVANSDYGFVDSYEQTPTPTPRSNASSTGPGGLMMS--GGESSAGVTSSKFNF 2026
            :...|..|.                .|.:|||...||...  .||.......:.|.|
Zfish   988 KFLNVFVNG----------------TSRSSSTESFGLFSCTINGEERDQTHRAVFRF 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926
mapk8ip2	XP_685086.6	SH3_JIP2	1021..1075	CDD:212875	2/8 (25%)
		PTB_JIP	1092..1242	CDD:269923

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574049
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840