DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dab and si:dkey-34e4.1

DIOPT Version :9

Sequence 1:	NP_001163455.2	Gene:	Dab / 39866	FlyBaseID:	FBgn0000414	Length:	2360	Species:	Drosophila melanogaster
Sequence 2:	XP_001919814.3	Gene:	si:dkey-34e4.1 / 558083	ZFINID:	ZDB-GENE-070705-456	Length:	628	Species:	Danio rerio

Alignment Length:	705	Identity:	147/705 - (20%)
Similarity:	255/705 - (36%)	Gaps:	206/705 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GVQFKAKLIGILEVGEARGDRMCQEALQDLKMAIRAAGEHKQRITIHVTIDGLRL-------RDE 105
            |:.|:||.:|.|:|...........|::.::...:|....|:::.|.|::||:::       |.|
Zfish    31 GIHFQAKYVGSLDVPRPNSRMEIVAAMRRIRYEFKAKSVKKKKVAIVVSVDGVKVVLRKKPKRKE 95

  Fly   106 KTGDS----LYHHPVHKISFIAQDMTDSRAFGYIF--GSPDSGH-RFFGIKTDKAASQVVLAMRD 163
            .|.|.    :...|:::|.:::.|..|.:.|.||.  ||.:|.. ..|..|....|.::|..:..
Zfish    96 WTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGSSNSFRCNVFKSKKKSQAMRIVRTVGQ 160

  Fly   164 LFQVVFELKKKEIEM-ARQQIQGKS------------------------------LHDHSSQLA- 196
            .|:|..:|..:..|: |.:|..|.:                              ...|.::|:
Zfish   161 AFEVCHKLSLQHAELNADEQPDGPADGQSDQSGEEPSPEGRQLTGMEHRTDDVTGTESHPTKLSE 225

  Fly   197 --------SLSSL-------------KSSGLGGMGLGHSDLASGG---ISSGHALTLLGSSLSTT 237
                    |||.|             :..|:....|..|...|..   :::.|.|.||...|...
Zfish   226 QAMDDILQSLSELNMVKPGQTIQSLQEVEGVSLYTLSPSSPCSPSLTPLATKHHLQLLQQQLLQQ 290

  Fly   238 NGTSRLGVS-----LDVAKASGSAAKEVSPESVADLV---DLEQELTSLQRGISQMERITPNEPT 294
            ...:::.|:     .|...|..:|..|....:...|:   ||.|....|.:.:||:|
Zfish   291 QQQTQIAVAQVQLLKDQLSAETAARMEAQARTHQLLLQNRDLLQHTALLVKHLSQLE-------- 347

  Fly   295 TSSTGGAGHPSLAKSASEDDPFGDSFIYVPSYSILPPPPDSGRNRHKPPNKTPDAVTSLDAMLSP 359
               ...||     .:..||.|:.:    :|:.|:    ..:.:|.:.|.::.|  :||..|..:.
Zfish   348 ---IRAAG-----DTQKEDSPWSN----LPTRSL----SLNLKNLYAPRSEQP--ITSTPAGPAE 394

  Fly   360 PPGTSSSHGSASAGLQAADNDDDNWLQELDQQNDVFDTSKVVSSSGLGSVLAMAPLASSESTATP 424
            ||..|||:.             :::|..|:.:     .::.|..||      ....|.||:....
Zfish   395 PPPVSSSNA-------------ESYLNLLNLR-----AAQTVPDSG------RPASARSEARLDS 435

  Fly   425 TQQLTEVAAGSGPLADLDIGLSTALGNEEQTSTILSLDAFTDLDPLGTGRTRPYVDKKYFFQELK 489
            ||:         .:|.|:...||||  :|:.|.|:     ..|||
Zfish   436 TQR---------EVAKLETRNSTAL--DERYSQII-----PKLDP-------------------- 464

  Fly   490 NPPKKLLKELSSGSQAGLGLGLSLGQLDGLFPEDSTTISTTTTTATNITAGN--PQQNSANTLTS 552
             ||:.|.::.|:.:       ||.|       .::...::|..||.|   ||  |..:::::...
Zfish   465 -PPQPLNRKRSNRT-------LSPG-------VEAEYRNSTIATAVN---GNILPNVSASSSFPD 511

  Fly   553 TASTAASLGQLLSTVALNPDPLPAPISIPTSISHSITPSAELKLLLGHVTNPPNPTGHYYTTEPP 617
            ....:.|.|...|..        ...|:..|.|......::.|.|:...:...:.:..:.:|. .
Zfish   512 ITLCSVSPGDFYSHT--------NGTSVSCSASEDSGVRSDDKSLISPQSRDDDQSSAFISTS-S 567

  Fly   618 TLNSLENPHPPAD-----PVLLPRDTDPFSPTRKKSDPDPFQESDLFAKLDAFEF 667
            |.:||...||.||     ....|..|.|||        .|..::.|...|...||
Zfish   568 TCSSLPEDHPAADGGSPRQSTTPEQTIPFS--------SPVNDTCLHISLSEDEF 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926	37/147 (25%)
si:dkey-34e4.1	XP_001919814.3	PTB_CAPON-like	5..182	CDD:269968	38/150 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574061
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840