DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dab and Ldlrap1

DIOPT Version :9

Sequence 1:	NP_001163455.2	Gene:	Dab / 39866	FlyBaseID:	FBgn0000414	Length:	2360	Species:	Drosophila melanogaster
Sequence 2:	NP_001102741.1	Gene:	Ldlrap1 / 500564	RGDID:	1563417	Length:	307	Species:	Rattus norvegicus

Alignment Length:	235	Identity:	59/235 - (25%)
Similarity:	102/235 - (43%)	Gaps:	38/235 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SSNLSLASTFGGGSGAAEETNYAKHRNDPGRFFG------DGVQFKAKLIGILEVGEARGDRMCQ 71
            |.:|:..|..||           :||..|..:..      :|:.|..|.:|:..|...:|:.:..
  Rat    14 SPSLAKQSWAGG-----------RHRKLPENWTDTRETLLEGMVFSLKYLGMTLVERPKGEELSA 67

  Fly    72 EALQDLKMAIRAAGEHKQRITIHVTIDGLRLRDEKTGDSLYHHPVHKISFIAQDMTDSRAFGYIF 136
            .|::.:....:|:|:..|::|:.|:..|:.|.|..|...:.:..:::||:...|....:.|.||.
  Rat    68 AAVKRIVATAKASGKKLQKVTLKVSPRGIILTDSLTSQLIENVSIYRISYCTADKMHDKVFAYIA 132

  Fly   137 GSPDSG----HRFFGIKTDKAASQVVLAMRDLFQVVFEL------KKKEIEMARQQ---IQGKSL 188
            .|..:.    |.|...|. |.|..|.|.:...|:|.||.      :|::.|.|.|:   :.|
  Rat   133 QSQQNESLECHAFLCTKR-KVAQAVTLTVAQAFKVAFEFWQVSKEEKEKREKANQEGGDVPG--- 193

  Fly   189 HDHSSQLASLSSLKSSGLGGMGLGHSDLASGGISSGHALT 228
                ::..|..|||:|...|..|...:||...:|:..|.|
  Rat   194 ----TRRDSTPSLKTSVATGNLLDLEELAKAPLSTVSANT 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926	40/161 (25%)
Ldlrap1	NP_001102741.1	PTB_LDLRAP-mammal-like	43..165	CDD:269981	30/122 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..205		8/32 (25%)
		Clathrin box. /evidence=ECO:0000250\|UniProtKB:Q5SW96	211..215		1/3 (33%)
		AP-2 complex binding. /evidence=ECO:0000250\|UniProtKB:Q5SW96	248..275
		[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. /evidence=ECO:0000250\|UniProtKB:Q5SW96	256..265
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334830
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840