Protein Alignment Dab and numbl

DIOPT Version :9

• Sequence 1: NP_001163455.2
• Gene: Dab / 39866
• FlyBaseID: FBgn0000414
• Length: 2360
• Species: Drosophila melanogaster
• Sequence 2: XP_005173435.1
• Gene: numbl / 497616
• ZFINID: ZDB-GENE-051113-340
• Length: 640
• Species: Danio rerio
• Alignment Length: 693
• Identity: 149/693 - (21%)
• Similarity: 230/693 - (33%)
• Gaps: 213/693 - (30%)

  Fly    51 FKAKLIGILEVGEARGDRMCQEALQDLKMAIRAAGEHKQRITIHVTIDGLRLRDEKTGDSLYHHP 115
            |..:.:|::||.|:||..:|:||::.||:    :|:...:..:.|:.||||:.|:||.|.:....
Zfish    61 FPVRYLGLVEVDESRGMHVCEEAVKKLKV----SGKKTVKAVLWVSADGLRVVDDKTKDLIVDQT 121

  Fly   116 VHKISFIAQDMTDSRAFGYI--------------FGSPDSGHRF--------------------- 145
            :.|:||.|.|....:||.||              ....|||.|.
Zfish   122 IEKVSFCAPDRNYDKAFSYICRDGTTRRWMCHCFMALKDSGERLSHAVGCAFAACLERKQRREKE 186

  Fly   146 FGIKTDKAASQVVLAMRDLFQVVFELKKKEIEMARQQIQGKSLHDHSSQLASLSSL---KSSGLG 207
            .|:.....||:........|:|....::.:.|...:|||     |...::..:|:|   .:|...
Zfish   187 CGVTASFDASRTSFVREGSFRVSSAAQQSDREDIMKQIQ-----DKKKEMCGISALPPGNASPPE 246

  Fly   208 GMGLGHSDLASGG---ISSGHA----LTLLGS-----SLSTTNGTSRLGVSLDVAKASGSAAKEV 260
            |.|........||   |...||    |...||     .||..|...:..:||.:.....:..::.
Zfish   247 GAGSPGERAEPGGPHAIPRRHAPIEQLVRQGSFRGFPQLSQKNSPFKRQLSLRLNDLPSTLQRKT 311

  Fly   261 -----SPESVADLVDLEQELTSLQRGISQMER--ITPNEPTTSSTGGAGHP-SLAKSASEDDPFG 317
                 :|....||. :..|..|:....||:..  ..|:|...:.|.....| |.|..|
Zfish   312 DFQTKNPVPEMDLT-VAGEADSINALCSQINSSFTKPSEDLCAKTTNNCLPISCAPPA------- 368

  Fly   318 DSFIYVPSYSILPPPPDSGRNRHKPPNKTPDAVTSLDAMLSPPPGTSSSHGSASAGLQAADNDDD 382
                       :||||            .|...|:|...:.||  ..||......|.:...::.:
Zfish   369 -----------IPPPP------------APPQATNLWVQIEPP--VQSSPPIPQGGHKRTPSEAE 408

  Fly   383 NWLQELDQQNDVFDTSKVVSSSGLGSVLAMAPLASSESTATPTQQ-----LTEVAAGSGPLADLD 442
            .||:|:         :|.|.|..........|         ||||     ...:|.||.|.:...
Zfish   409 RWLEEV---------AKAVKSQQQTPPTLPPP---------PTQQPPPVPTMPIAPGSLPTSMQP 455

  Fly   443 IGLSTALGNEEQTSTILSLDAFTDLDPLGTGRTRPYVDKKYFFQELKN--------------PPK 493
            ..::.     :.|...:|:.....|.|       .:|..:.:...|.|              .|.
Zfish   456 FPMAF-----DVTPAPVSMFTQQPLQP-------AFVPMQPYMPTLANSMTYPNASVPVVGITPS 508

  Fly   494 KLLKEL-------SSGSQAGLGLGLSLGQLDG----LFPEDSTTISTTTTTATNITAGNPQQNSA 547
            :::..:       ..|...|:|:|...|.|.|    .||.....:.|||..:.....|:||.:..
Zfish   509 QMVANVFCSAAGTGGGVAIGVGMGPKTGTLGGSQHSAFPTLPGGLPTTTFASPPTINGHPQNSFP 573

  Fly   548 NTLTSTA--STAASLGQLLSTVALNPDPLPAPISIPTSISHSITPSAELKLLLGHVTNPPNPTGH 610
            :|.||..  .||...|.                                    |.....||
Zfish   574 STTTSVTQNGTAVKGGS------------------------------------GWPMENPN---- 598

  Fly   611 YYTTEPPTLNSLENPHPPADPVLL-----PRDTDPFSPTRKKS 648
                  ||:||.|..|..|....|     |:..:|||...:|:
Zfish   599 ------PTINSKEAEHFDAKWAALESKSQPKAQNPFSNDLQKT 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926	41/164 (25%)
numbl	XP_005173435.1	PTB_Numb	45..179	CDD:241298	35/121 (29%)
		NumbF	260..344	CDD:283874	18/84 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574045
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840