DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dab and c8a

DIOPT Version :9

Sequence 1:	NP_001163455.2	Gene:	Dab / 39866	FlyBaseID:	FBgn0000414	Length:	2360	Species:	Drosophila melanogaster
Sequence 2:	XP_009294923.1	Gene:	c8a / 445102	ZFINID:	ZDB-GENE-040801-239	Length:	592	Species:	Danio rerio

Alignment Length:	283	Identity:	63/283 - (22%)
Similarity:	96/283 - (33%)	Gaps:	69/283 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 HVTIDGLRLRDEKTGDSLYHHPVHKISF--IAQDMT--------DSRAF--------GYIFG-SP 139
            |::.|        ..:..|..|.:.:||  :||..|        |:.:|        .:.|| .|
Zfish   212 HLSYD--------DAEKYYRKPYNFLSFQIMAQASTEESSDYYEDAVSFLRAKHSENSFNFGIKP 268

  Fly   140 DSGHRFFGIK--------------TDKAASQVVLAMRDLFQVVFELKKKEIEMARQQIQGKS-LH 189
            ..|...||::              |:|....|.| |..:....|:::.|::.:....:...| |.
Zfish   269 QIGFVEFGVEFSAEFMFLNNISKYTNKEMGFVQL-MSKIQTSQFKMRSKDLVLDEDMLWALSDLP 332

  Fly   190 DHSSQLASLSSLKSSGL-----GGMGLGHSD-LASGGISSGHALTLLGSSLSTTNGTSRLGVSLD 248
            ||....|........|.     |.|| |..| :|...|:......:.|..:.:..|.|...|.::
Zfish   333 DHYHFGAYSQFFNEYGTHYVTEGTMG-GLMDYVAVVNINEMEENQMTGQMIGSCIGGSFGLVFME 396

  Fly   249 VAKAS---GSAAKEVSPESVADLVDLEQELTSLQRGISQMERITPNEPTTSSTGGAGHPSLAKSA 310
            ..||:   .|..|..|.|..:|         .....|..:........|.||.|..|    .|.|
Zfish   397 KIKATVKGKSCGKFTSNEKTSD---------ESHSAIKDVFGFVKGGNTASSAGSLG----IKDA 448

  Fly   311 SEDDPFGDSFIYVPS---YSILP 330
            .....:|.|..|.|:   :.|||
Zfish   449 KSYKDWGKSLKYNPALIEFEILP 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926	24/119 (20%)
c8a	XP_009294923.1	LDLa	105..146	CDD:294076
		MACPF	279..499	CDD:280069	46/208 (22%)
		TSP1	<562..592	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3535
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900