DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dab and dab2

DIOPT Version :9

Sequence 1:	NP_001163455.2	Gene:	Dab / 39866	FlyBaseID:	FBgn0000414	Length:	2360	Species:	Drosophila melanogaster
Sequence 2:	NP_001314800.1	Gene:	dab2 / 404040	ZFINID:	ZDB-GENE-040303-1	Length:	797	Species:	Danio rerio

Alignment Length:	944	Identity:	241/944 - (25%)
Similarity:	358/944 - (37%)	Gaps:	304/944 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RFFGDGVQFKAKLIGILEVGEARGDRMCQEALQDLK---MAIRAAGEHKQRITIHVTIDGLRLRD 104
            ||.||||::||||||:.:|.:||||:|||:::..||   :|.|:.|:|||||.|::::.|:::.|
Zfish    56 RFQGDGVRYKAKLIGVDDVQDARGDKMCQDSMMKLKGMAIAARSQGKHKQRIWINISLTGIKIVD 120

  Fly   105 EKTGDSLYHHPVHKISFIAQDMTDSRAFGYIFGSPDSGHRFFGIKTDKAASQVVLAMRDLFQVVF 169
            ||||...:.|.|:||||||:|:||:|||||:.|: :..|:||.|||.:.|..:|:.::||||::|
Zfish   121 EKTGVIEHEHVVNKISFIARDVTDNRAFGYVCGA-EGQHQFFAIKTAQQAEPLVIDLKDLFQLIF 184

  Fly   170 ELKKKEIEMARQQIQGKSLHDHSSQLASLSSLKSSGLGGMGLGHSDLASGGISSGHALTLLGSSL 234
            .:||||.| |.|:.:|....:                ||..|...|.....:.|...:.|.| .:
Zfish   185 NMKKKEQE-AGQKGEGNGTEN----------------GGDALLAVDGNENPVKSVEQMNLFG-DM 231

  Fly   235 STTNGTSRLGVSLDVAKASGSAAKEVSPESVADLVDLEQELTSLQRGISQMERITP--------- 290
            ||..         |:        ...:|:||     |..||:.|..| :|:.:..|
Zfish   232 STPP---------DI--------HSPTPDSV-----LLLELSDLFDG-NQVNQDNPFITNPSPLC 273

  Fly   291 NEP---TTSSTGGAGHPSLAKSASEDDPFGDSFIYVPSYSILPPPPDSGRNRHKPPNKTPDAVTS 352
            |:|   :.|||... .|:|:.....||||                        .|.|...|:|.|
Zfish   274 NKPFDKSASSTSDL-FPTLSSDPFSDDPF------------------------SPLNDQSDSVFS 313

  Fly   353 LDAMLSPPPGTSSSHGSASAGLQAADNDDDNWLQELDQQNDVFDTSKVVSSSGLGSVLAMAPLAS 417
                       |::....|:.|....:..::...:..|.|.:||:.                 .|
Zfish   314 -----------SNNESDFSSFLLNGPDSSEDPSPKSQQFNKLFDSQ-----------------LS 350

  Fly   418 SESTATPTQQLTEVAAGSGPLADLDIGLSTALGNEEQTSTILSLDAFTDL---DPLGTGRTRPYV 479
            :||.....|||        |::||:.|          |::|.|.:.|..:   :|       |.|
Zfish   351 NESPNNQVQQL--------PISDLNGG----------TNSIFSQNPFLSISLNNP-------PIV 390

  Fly   480 DKKYFFQELKNPPKKLLKELSSGSQAGLGLGLSLGQLDGLFPEDSTTISTTTTTA-----TNI-- 537
            :..|     .:.|..|...|.:||...|.|         .....|||:.....||     .|:
Zfish   391 NGLY-----SSDPPVLQAPLCNGSNKQLAL---------FQTNPSTTVQNGGLTALCPPPQNLKP 441

  Fly   538 --------TAGN----------PQQNSANTLTSTA--------STAASLGQLLSTVALNPDPLPA 576
                    :.||          |.||.:......|        ||.:|......:::|...|..|
Zfish   442 RCARRREKSPGNDLFGSGLFAPPAQNESQASNQNASIPADLFNSTPSSTINAFGSMSLGHAPGTA 506

  Fly   577 PIS---IPTSISHSITPSAELKLLLGHVTNPPNPTGHYYTTEPPTLNSLENPHPPADPVLLPRDT 638
            |:|   .||    ...|.|.:::.   :..||.|     ..:|.....|      :.|....:..
Zfish   507 PVSWGQTPT----MFPPQAGVQVT---IPGPPRP-----FPQPSAFGGL------SAPAWGQQGA 553

  Fly   639 DPFSP---TRKKSDPDPFQESDLFAKLDAFEFEAPPAVPAPSIPNLATETKANVFNGPLQVQLPP 700
            .||.|   |:....|.        |......:.||..|.:|..||            .....:||
Zfish   554 SPFGPPAGTQAWGQPG--------AAAPVGTWPAPGPVASPFQPN------------QFAPMMPP 598

  Fly   701 EKELQLQQ---------PPSTVRNRPTASVSALPSGGALDVISSISNKKMPHLFGQARSFGKSGS 756
            ...:.:||         |...|:..|....||..   |||.:            |:..|  |||.
Zfish   599 NAMMGMQQGAVAPPRPPPRPPVKEEPPVVKSAFT---ALDPL------------GEKES--KSGK 646

  Fly   757 DIGSSVNMRRLQESDSLSETEAAPEPPPRPDSTP-----YSEPPPL-PPKKQFSDLVIRPSPAN- 814
            |:..:..|.:.|:          |||.|.|::..     :|....| .......|..|....||
Zfish   647 DMFKNFQMVKPQK----------PEPGPDPNTNGSFDQYFSNKVGLAQDAADHDDFEINQISANS 701

  Fly   815 --TTQPPTSGRYEYLNSNVTARRTASSVDAPP-----IPLPSRRVGRSDGCF-----PGPGRPRK 867
              |::|              |.:...::||.|     ||.|:  .|..|..|     |.|..|..
Zfish   702 NGTSKP--------------ASQLIPTMDAIPQAAGLIPAPA--TGLLDVAFSSNPVPAPTNPAP 750

  Fly   868 PGHTE--DDYLA--PLGAPPPLLPPPSQGSSARA 897
            ...|:  ||...  |.|||......|:..::|.|
Zfish   751 AAGTDLFDDTFGVNPFGAPLMNTSTPATQNAALA 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926	73/140 (52%)
dab2	NP_001314800.1	PTB_Dab	47..196	CDD:269926	73/141 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574063
Domainoid	1	1.000	124	1.000	Domainoid score	I5446
eggNOG	1	0.900	-	-		E1_KOG3535
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002247
OrthoInspector	1	1.000	-	-		otm25692
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11232
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2975
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.920