DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dab and C1orf226

DIOPT Version :9

Sequence 1:	NP_001163455.2	Gene:	Dab / 39866	FlyBaseID:	FBgn0000414	Length:	2360	Species:	Drosophila melanogaster
Sequence 2:	NP_001128712.1	Gene:	C1orf226 / 400793	HGNCID:	34351	Length:	315	Species:	Homo sapiens

Alignment Length:	290	Identity:	68/290 - (23%)
Similarity:	99/290 - (34%)	Gaps:	86/290 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 LLGSSLSTT-------NGTSRLGVSLDVAKASGSAAKEVSPESVADL-----------VDLEQEL 275
            ||...||.|       |..:.|...|..:::....:|.|:|.| |.|           |...|.|
Human    31 LLSEPLSRTVDHGMFENLNTALTPKLQASRSFPHLSKPVAPGS-APLGSGEPGGPGLWVGSSQHL 94

  Fly   276 TSLQR--GISQMERITPNEPTTSSTGGAGHPSLAKSASEDDPFG-----------DSFIYVPSYS 327
            .:|.:  |....:.:...||  ||.|..|...:.|:|......|           :..:...::.
Human    95 KNLGKAMGAKVNDFLRRKEP--SSLGSVGVTEINKTAGAQLASGTDAAPEAWLEDERSVLQETFP 157

  Fly   328 ILPPPPDSGRNRHKPPNKTPDAV-TSLDAMLSPPP-------GTSSSHGSASAGLQA------AD 378
            .|.|||...|.|      ||.|: |:.|.::|..|       ||..|.|.|......      ||
Human   158 RLDPPPPITRKR------TPRALKTTQDMLISSQPVLSSLEYGTEPSPGQAQDSAPTAQPDVPAD 216

  Fly   379 NDDDNWLQELDQQNDVF------------------DTSKV-------VSSSGL----GSVLAMAP 414
            ........|.:::..|.                  |.||:       .||..|    |..|:::|
Human   217 ASQPEATMEREERGKVLPNGEVSLSVPDLIHKDSQDESKLKMTECRRASSPSLIERNGFKLSLSP 281

  Fly   415 LASSES---TATPTQQLTEVAAGSGPLADL 441
            ::.:||   .:.|.|..|......||..||
Human   282 ISLAESWEDGSPPPQARTSSLDNEGPHPDL 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926
C1orf226	NP_001128712.1	DUF4628	44..315	CDD:292069	63/277 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141163
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930