DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dab and CG42673

DIOPT Version :9

Sequence 1:	NP_001163455.2	Gene:	Dab / 39866	FlyBaseID:	FBgn0000414	Length:	2360	Species:	Drosophila melanogaster
Sequence 2:	NP_729510.1	Gene:	CG42673 / 39111	FlyBaseID:	FBgn0261555	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	1100	Identity:	206/1100 - (18%)
Similarity:	352/1100 - (32%)	Gaps:	408/1100 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   626 HPPADPVLLPRDTDPFSPTRKKSDPDPFQESDLFAKLDAFEFEAPPAVPAPSIPNLATETKA--- 687
            |..:...::||     ||..|..|..|:..|.  :|::..:.::.||....|:..:....|:
  Fly    17 HADSSAHVVPR-----SPITKAFDFLPWTRSR--SKVNMTKVQSQPAEQQASVSTVTPAEKSSEV 74

  Fly   688 ----NVF---NGPLQVQLPPEKELQLQ-QPPSTVRNRPTASVSALPSGGALDVISSISNKKMPHL 744
                |:|   .|.::..|..:|.|||: :||.          |.:||          ..||..||
  Fly    75 HYHKNIFRSGGGLIRDILVGDKNLQLKDKPPQ----------SPVPS----------HKKKQKHL 119

  Fly   745 FGQARSFGKSGSDIGSSVNMRRLQESDSLSETEAAPEPPPRPDSTPYSEPPPLPPKKQFSDLVIR 809
               :|:         .|:::|.|   ....|.|.|    |.....|.|:||     :...|..|.
  Fly   120 ---SRN---------KSLDIREL---IGCVEREMA----PATGGGPVSQPP-----RFIDDTYID 160

  Fly   810 PSP--------ANTT------QPPTSGRYEYLNSNVTARRTASSVDAPPIPLPSRRVGRSDGCFP 860
            ..|        .||.      ||.....::  .||.|:....|:.|.....|..:|:       |
  Fly   161 HKPKHILFNDDENTVYIIKKEQPVAKSSHK--ASNSTSNAAQSNGDVLKARLKFKRL-------P 216

  Fly   861 GPGRPRKPGHTEDDYLAPLGAPPPLLPPPSQGSSARARPQRQASLGRPQDIYENKAEILQAQAQA 925
            |......|......:|.            .|.|..|.:.||:.||...|
  Fly   217 GDHYEASPEALRRAHLL------------HQRSEQRHQLQRRKSLSDQQ---------------- 253

  Fly   926 QAQAPEVAPSSNTLAP----------DITLTQLLTLGMDDLAIKLNVPASKLSTMTLVQLTAYLS 980
                     ||::|:.          .|.|.:          .|.:.|..|||....:.....:.
  Fly   254 ---------SSSSLSSGGGGGGNANGSIMLER----------PKTDKPRKKLSFREPIIAGDQIL 299

  Fly   981 EYLSSEKSQVHSQERRSSPANTAPAPASTAAVFKVNFDQQTSFVAKFDDTF-GEDEPVMPSGSSD 1044
            ..:.||:.|.. |.|||||...:....:               :|..|:.. ...:..:..|.:.
  Fly   300 PLILSEQRQAR-QRRRSSPLERSRVGLA---------------IADCDNLCNNRTKDAISCGCAT 348

  Fly  1045 STFVANFANFNDAPTPVPTVSPVVATV------------------PSADRYAV-FREIID-QELQ 1089
            |             .|......:|.||                  |:.:|..: ..|::| :::.
  Fly   349 S-------------DPESQAMRIVRTVGQAFEVCHKFNLHKNSLEPNDERSDISSSELLDVEQIS 400

  Fly  1090 QQQQETDLM---GDLTPPPVDETQAKE-ISEGLEVNNVGAELPIDALDVKPAPK----------- 1139
            :||...|..   ||      :||..|| ::...::|:...:.| :.||:.|:..
  Fly   401 EQQLSEDGERGGGD------NETPKKEHLAITPDLNHTQPQRP-NHLDIMPSHSSLRKSNSLLCD 458

  Fly  1140 IDTK-----------IT----EVVAQAKDRYAALRDIILV-ENLFDKPAIATDTQPEKEKDLLQD 1188
            :|.|           ||    ::.|||.....||..::|| |.|..:.....:.|...::.|.|:
  Fly   459 VDDKSPGSPSSPRSEITQLKDQLEAQALQTRQALGQLMLVREQLISETNARIEAQARTQQLLQQN 523

  Fly  1189 FPEFSDEFNEDHDLRQIMDHQNVQTHARDRHGLVDSRGFPTEPSSSALTVGDYDEDEDAD----- 1248
                          |::::|                          ..::|.|:|.:.|.
  Fly   524 --------------RELLEH--------------------------LASLGAYNEQQTAGLTSAN 548

  Fly  1249 ---AGGESSLD------SNEKDAEPVSGQ--------DQYEKLSTSTQQLDAAAPALEDVQQLQQ 1296
               |..:|.|.      ||..:...::.|        .|...||.....|:..:..|:::||.||
  Fly   549 IGMAPQQSQLQMLLQATSNNNNLATINQQISNLGSINQQLTSLSHQLSGLNQQSQHLQNLQQQQQ 613

  Fly  1297 QSLPPKQDQKFLSILTA---PGGG------------------------------TKDDIEIDELM 1328
            |....:|.|...:...|   |..|                              :||..::::.:
  Fly   614 QQQQQQQQQTQAAPTAATPPPAAGGSSPYPSMSALQSISNQLQQQQQQQQQDALSKDLFQVNQEL 678

  Fly  1329 HRAISNLSLDSRDRVSPATSS-----------------AAPSRGAPGLHTPSQFNDVSTSPIPLQ 1376
            ...:..|:|::....|..|.|                 |.|:..|.|   ...||.:::   |..
  Fly   679 LNRLQALNLNANPGQSQPTPSATAHNSFFYVNPLSCTPATPNNNAGG---AGGFNFLTS---PAA 737

  Fly  1377 KPGMGPSPVPSQ-------LSAVSQLIDTATKQMMGDKDREKQ---------------SWATFDS 1419
            ...:.|||:.:.       .|::::.|..:.:|.:.:.:.:.:               |.:|.|:
  Fly   738 TGTLTPSPLGTMNRNSFAGSSSLNEDIRLSIEQNLNNLEEQLKAAVSNGNLAGLACGGSTSTRDT 802

  Fly  1420 PKAKGKARLTLPPPPPPASNTSQPDTVESPCSSDPRDDGWSKQQRRWAKKERQQTSSSSRD---- 1480
            .::..    ||..|..|...:|..:.  ||.||:...:         ........|||||:
  Fly   803 SRSSS----TLDSPSSPRLRSSNNNI--SPGSSNGNQN---------HNNNSNSNSSSSRETRFN 852

  Fly  1481 --LSPWDDE---------TPEYLKRRQLAAAQMAHPHQPPMQAPPQHTDRHGYYMRHARR 1529
              |....||         ||.::.|    :.....|::..|.:..|.|.    :.||..:
  Fly   853 TVLLRVTDEAGHQRKLSATPSFITR----STSEKVPNRSQMMSQVQRTT----WARHTTK 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926
CG42673	NP_729510.1	PH-like	<352..386	CDD:302622	4/33 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438627
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11232
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940