Protein Alignment Dab and numb

DIOPT Version :9

• Sequence 1: NP_001163455.2
• Gene: Dab / 39866
• FlyBaseID: FBgn0000414
• Length: 2360
• Species: Drosophila melanogaster
• Sequence 2: NP_001260291.1
• Gene: numb / 34263
• FlyBaseID: FBgn0002973
• Length: 556
• Species: Drosophila melanogaster
• Alignment Length: 598
• Identity: 134/598 - (22%)
• Similarity: 201/598 - (33%)
• Gaps: 184/598 - (30%)

  Fly    51 FKAKLIGILEVGEARGDRMCQEALQDLKMAIRAAGEHKQRITIHVTIDGLRLRDEKTGDSLYHHP 115
            |..|.:|.:||.|:||.::|:|||:.|:.:.|    ...|..:||:.||||:.|::|...:....
  Fly    83 FSVKYLGCVEVFESRGMQVCEEALKVLRQSRR----RPVRGLLHVSGDGLRVVDDETKGLIVDQT 143

  Fly   116 VHKISFIAQDMTDSRAFGYIFGSPDSG----HRFFGIKTDKAASQVVLAMRDLFQVVFELKKKEI 176
            :.|:||.|.|....|.|.||.....:.    |.|...|  .:..::..|:...|.|..|.|::
  Fly   144 IEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACK--DSGERLSHAVGCAFAVCLERKQR-- 204

  Fly   177 EMARQQIQGKSLHDHSSQLASLSSLKSSGLGGMGLGHSDLASGGISSGHALTLLGSSLSTTNGTS 241
                        .|....:......|:|.....|            |....||.......|.||:
  Fly   205 ------------RDKECGVTMTFDTKNSTFTRTG------------SFRQQTLTERLAMATVGTN 245

  Fly   242 RLGVSLDVAKASGSAAKEVSPESVADLVDLEQELTSLQRGISQMERITPN--EPTTS---STGGA 301
            ...|....:...|..|..|.|.:...:               :....|||  |..:|   ||.|:
  Fly   246 ERSVDGPGSAMPGPPAATVKPFNPFAI---------------ERPHATPNMLERQSSFRLSTIGS 295

  Fly   302 GHPSLAKSASEDDPFGDSFIYVPSYSILPPPPDSGRNR------HKPPNKTPDAVTSLDAMLSPP 360
            ..|               |....|..|...|.::.|.|      ...|.:||  :.|:..:....
  Fly   296 QSP---------------FKRQMSLRINDLPSNADRQRAFLTAAAGNPMQTP--LRSVSPIAEVS 343

  Fly   361 PGTSSSHGSASAGLQAADNDDDNWLQELDQ------QNDV---------FDTSKVVSSSGLGSVL 410
            |..|:.....||...|||: .....|||.|      |.|.         |:.::.::.:   .:.
  Fly   344 PAKSAGADPLSAAAVAADS-VSQLCQELSQGLSLLTQTDALLAAGEDLNFNNNRSINQN---IIA 404

  Fly   411 AMAPLASSESTATPTQQLTEVAAGSGPL-----------ADLDIGLSTALGNEEQTSTILSLDAF 464
            |...:....|.|.||.|:|...|.:.|.           ::..|..||.|.|.||.
  Fly   405 AEKQVQHVHSYAPPTAQVTPRVASTTPTYQTLHSQSPSRSEQSIETSTELPNAEQW--------- 460

  Fly   465 TDLDPLG--TGRTRPYVDKKYFFQELKNPPKKLLKELSSGSQAGLGLGLSLGQLDGLFPEDSTTI 527
                 ||  ...|.|...|:..:  |.|..:  .:.|:||:.|.:|.|   |..|   |.|:..:
  Fly   461 -----LGHVVRSTSPAAPKRPTY--LANVGR--AQTLASGTGAAVGGG---GPDD---PFDAEWV 510

  Fly   528 STTTTTATNITAGNPQQNSANTLTSTASTAASLGQLLSTVALNPD-PLPAPISIPTSISHSITPS 591
            :       |:.|..                          .|:|| |:|:....|
  Fly   511 A-------NVAAAK--------------------------QLSPDLPIPSTARSP---------- 532

  Fly   592 AELKLLLGHVTNP 604
                 |..|.|||
  Fly   533 -----LARHSTNP 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926	40/133 (30%)
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	38/123 (31%)
		NumbF	269..374	CDD:283874	30/137 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438632
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11232
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940