DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dab and Mapk8ip2

DIOPT Version :9

Sequence 1:	NP_001163455.2	Gene:	Dab / 39866	FlyBaseID:	FBgn0000414	Length:	2360	Species:	Drosophila melanogaster
Sequence 2:	NP_001094190.1	Gene:	Mapk8ip2 / 315220	RGDID:	1309727	Length:	835	Species:	Rattus norvegicus

Alignment Length:	807	Identity:	162/807 - (20%)
Similarity:	245/807 - (30%)	Gaps:	278/807 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 SSSHGSASAGLQAADNDDDNWLQELDQQNDVFDTSKVVSSSGLGSVLAMAPLASSESTATPTQQL 428
            |:.|..:..|.:.   ..|..|:|.|.:    |.|::....|||        .|.:|.......|
  Rat    11 STFHSLSPPGCRP---PQDISLEEFDDE----DLSEITDDCGLG--------LSYDSDHCEKDSL 60

  Fly   429 TEVAAGSGPLADLDIGLSTALGNEEQTSTILSL-DAFTDLDPLGTGRTRPYVDKKYFFQELKNPP 492
                               :||..||...|.|. |.|.:.:.:.        |.:....|.:...
  Rat    61 -------------------SLGRSEQPHPICSFQDDFQEFEMID--------DNEEEEDEEEEEE 98

  Fly   493 KKLLKELSSGSQAGLGLGLSLGQLDGLFP----EDSTTISTTTTTATNITAGNPQQNSANTLTST 553
            ::..::.....:||.|.|......:.|.|    |:|..:..||...|.:.|    |:|.|..::.
  Rat    99 EEEEEDGDGDGRAGGGSGSQELSGESLIPSPSIEESHKLRPTTLHLTTLGA----QDSLNNNSNG 159

  Fly   554 ASTAASLGQLLSTVALNP--DP---LPAPISIPTSISHSITPSAELKLLLGHVTNPPNPTGHYYT 613
            ..|:|.......||..:|  :|   ||||: :|....|.            .|.:...|......
  Rat   160 GFTSAPPSSWQETVLRSPVQEPLKELPAPL-LPAEEEHH------------EVQSLARPGCDCEG 211

  Fly   614 TEPPTLNSLENPHPPADPVLLPRDTDPFSPTRKKSDPDPFQESDLFAKLDAFEFEAPPAVPAPSI 678
            .:|        |.|||.....|             ..||..|:||
  Rat   212 NQP--------PEPPASGGASP-------------SSDPGIEADL-------------------- 235

  Fly   679 PNLATETKANVFNGPLQVQLPPEKELQLQQPPSTVRNRPTASVSALPSGGAL--DVISSISNKKM 741
                ....:....|....|       :|..|.|          .:..:|||.  .:|||||..::
  Rat   236 ----RSHSSGGHEGRRSSQ-------ELSSPGS----------DSEEAGGARLGRMISSISETEL 279

  Fly   742 PHLFGQARSFGKSGSDIGSSVNMRRLQESDSLSETEA-APEPPPRPDSTPYSEPPPLPPKKQFSD 805
                       :..||.||| :.|....::|:.|..: |.||.|.|:..|..|||.
  Rat   280 -----------ELSSDSGSS-SGRSSHLTNSIEEASSPASEPEPEPEPEPLHEPPR--------- 323

  Fly   806 LVIRPSPANTTQPPTSGRYE----------------YLNSNVTAR---------RTASSVDAPPI 845
               ||:.....|..|:..||                :|.||:.:|         |......:||.
  Rat   324 ---RPAFLPVGQDDTNSEYESGSESEPDLSEDADSPWLLSNLVSRMISEGSSPIRCPGQCLSPPA 385

  Fly   846 PLPSRR-------------------------VGRSDGCFPGPGRPRKP-------------GHTE 872
            |.|...                         |.....|.|.|..|..|             .:..
  Rat   386 PRPPEEAASQANPVPQDCPDPEAVAGPHVELVDMDTLCGPPPPAPAAPRLGPAQSGPCLFLSNPT 450

  Fly   873 DDYLAPLGAPPPLLPPPSQGSSARARPQRQASLGRPQDIYENKAEILQAQAQAQAQAPEVAPSSN 937
            .|.:.||.|||          ...|||.|..|....::..|::.|  ..:.:..|:...:.|.|.
  Rat   451 RDTITPLWAPP----------GRTARPGRSCSAACSEEEEEDEEE--DEEDEEDAEDSVIPPGSR 503

  Fly   938 TLAPDITLTQLLTLGMDDLAIKLNVPASKLSTMTLVQLTAYLSEYLSSEKSQVHSQERRSSPANT 1002
            |......|...|...    |:|..:...:.:.:.||.|.....  |.::     |:|..|..|:.
  Rat   504 TTGSTAPLDASLVYD----AVKYTLVVDEHTQLELVSLRRCAG--LDND-----SEEDSSCEASE 557

  Fly  1003 APAPASTAAVFKVNFDQQTSFVAKFDDTFGED---EPVMPSGSSDSTFVANFANFNDAPTPVPTV 1064
            ..|.|:                     ..|.|   |...|. |.|.||...|.|.....|
  Rat   558 EEAGAT---------------------LLGSDQVPEDASPD-SPDLTFSKKFLNVFVNST----- 595

  Fly  1065 SPVVATVPSADRYAVFREIIDQELQQQ 1091
                :...|.:.:.:|..:::.|.::|
  Rat   596 ----SRSSSTESFGLFSCVVNGEEREQ 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926
Mapk8ip2	NP_001094190.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		3/17 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	44..357		92/450 (20%)
		JNK-binding domain (JBD). /evidence=ECO:0000250\|UniProtKB:Q9ERE9	111..278		53/245 (22%)
		Necessary for interaction with FGF13. /evidence=ECO:0000250\|UniProtKB:Q13387	242..509		68/319 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	369..509		28/151 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	544..579		10/61 (16%)
		SH3_JIP2	619..673	CDD:212875	162/807 (20%)
		PTB_JIP	690..835	CDD:269923
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334819
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930