Protein Alignment Dab and Numbl

DIOPT Version :9

• Sequence 1: NP_001163455.2
• Gene: Dab / 39866
• FlyBaseID: FBgn0000414
• Length: 2360
• Species: Drosophila melanogaster
• Sequence 2: XP_006228627.1
• Gene: Numbl / 292732
• RGDID: 1307579
• Length: 641
• Species: Rattus norvegicus
• Alignment Length: 724
• Identity: 150/724 - (20%)
• Similarity: 221/724 - (30%)
• Gaps: 275/724 - (37%)

  Fly    51 FKAKLIGILEVGEARGDRMCQEALQDLKMAIRAAGEHKQRITIHVTIDGLRLRDEKTGDSLYHHP 115
            |..:.:|.:||.|:||..:|::|::.||    |.|....:..:.|:.||||:.|:||.|.|....
  Rat   107 FPVRYLGHVEVEESRGMHVCEDAVKKLK----AMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQT 167

  Fly   116 VHKISFIAQDMTDSRAFGYIFGSPDSG----HRFFGIKTDKAASQVVLAMRDLFQVVFELKKKEI 176
            :.|:||.|.|....:||.||.....:.    |.|..:|  .:..::..|:...|....|
  Rat   168 IEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALK--DSGERLSHAVGCAFAACLE------ 224

  Fly   177 EMARQQIQGKSLHDHSSQLASLSSLKSSGLGGMGLGHSDLASGGISSGHALTLLGSSLSTTNGTS 241
               |:|.:.|.....::..||.:|....|        |...|||          |.......|
  Rat   225 ---RKQRREKECGVTAAFDASRTSFAREG--------SFRLSGG----------GRPAEREAG-- 266

  Fly   242 RLGVSLDVAKASGSAAKEVSPESVADLVDLEQELTSLQRGISQMERITPNEPTTS--STGGAGHP 304
                  |..||..:||..|:|                  |.:|...::|...|||  ..|.||.|
  Rat   267 ------DKKKAEAAAAPAVAP------------------GPAQPGHVSPTPATTSPGEKGEAGTP 307

  Fly   305 SLAKSASEDDP----------FGDSFIYVPSYSILPPP------------PDSGRNR-------- 339
            ..|.:.:...|          ...||...|:.|....|            |.:.:.|
  Rat   308 VAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGT 372

  Fly   340 ---HKPPNK-TPDAVTSLDAMLS--------PPPGTSSSHGSASA--------------GLQAAD 378
               .:||.. ..|.:::|...:|        |.||..|:....||              |.:...
  Rat   373 VPEMEPPGTGDSDGISALCTQISSSFASAGAPVPGPPSATTGTSAWGEPSVPAATAFQPGHKRTP 437

  Fly   379 NDDDNWLQEL-----------------DQQNDVFDTSKVVSSSGLGSVLAMAPLASSESTATPTQ 426
            ::.:.||:|:                 .||.......:...::.:..:..|||.....||
  Rat   438 SEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQQQQQQATSVPPMPTMAPTLQPFST----- 497

  Fly   427 QLTEVAAGSGPLADLDIGLSTALGNEEQTSTILSLDAFTDLDPLGTGRTRPYVDKKYFFQELKNP 491
                      |:...|...:       |.:..|..   |.:.|       |:|.
  Rat   498 ----------PVGPFDTAAA-------QVAVFLPP---THMQP-------PFVP----------- 524

  Fly   492 PKKLLKELSSGSQAGLGLGLSLGQLDGLFPEDSTTISTTTTTATNITAGNPQQNSANTLTSTAST 556
                       :..|||           :|      .........||   |.|..||...|.|..
  Rat   525 -----------AYPGLG-----------YP------PMPRVPVVGIT---PSQMVANAFCSAAQL 558

  Fly   557 AASLGQLLSTVALNPDPLPAPISIPTSISHSITPSAELKLLLGHVTNPPNPTGHYYTTEPPTLNS 621
            ......||......|.|     :.|::      |..:.:         |.|.|..:   ||
  Rat   559 QPQPATLLGKAGAFPPP-----TAPSA------PGGQAR---------PRPNGAPW---PP---- 596

  Fly   622 LENPHPPADPVLLPRDTDPFSPTRKKSDPDPFQESDLFAKLDAFEFEAPPAVPAPSIPNLATETK 686
              .|.|...|.|                 |||:..  :|.|     |..|||..||
  Rat   597 --EPAPAPAPEL-----------------DPFEAQ--WAAL-----EGKPAVEKPS--------- 626

  Fly   687 ANVFNGPLQ 695
             |.|:|.||
  Rat   627 -NPFSGDLQ 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926	38/133 (29%)
Numbl	XP_006228627.1	PTB_Numb	91..225	CDD:241298	38/132 (29%)
		NumbF	314..398	CDD:283874	13/83 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334815
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840