Protein Alignment Dab and Dab1

DIOPT Version :9

• Sequence 1: NP_001163455.2
• Gene: Dab / 39866
• FlyBaseID: FBgn0000414
• Length: 2360
• Species: Drosophila melanogaster
• Sequence 2: XP_017448664.1
• Gene: Dab1 / 266729
• RGDID: 628770
• Length: 588
• Species: Rattus norvegicus
• Alignment Length: 605
• Identity: 171/605 - (28%)
• Similarity: 250/605 - (41%)
• Gaps: 153/605 - (25%)

  Fly    43 RFFGDGVQFKAKLIGILEVGEARGDRMCQEALQDLKMAI---RAAGEHKQRITIHVTIDGLRLRD 104
            ||.|:||::|||||||.||..||||::||:::..||..:   |:.|||||:|.:.::..|:::.|
  Rat    34 RFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFD 98

  Fly   105 EKTGDSLYHHPVHKISFIAQDMTDSRAFGYIFGSPDSGHRFFGIKTDKAASQVVLAMRDLFQVVF 169
            ||||...:||.||:||:||:|:||.|||||:.|. :..|||..|||.:||..|:|.:|||||:::
  Rat    99 EKTGALQHHHAVHEISYIAKDITDHRAFGYVCGK-EGNHRFVAIKTAQAAEPVILDLRDLFQLIY 162

  Fly   170 ELKKKEIEMARQQIQGKSLHDHSSQLASLSSLKSSGLGG-------MGLGHSDLASGGISSGHAL 227
            |||:      |::::.|:..|...:.|...::....:..       ...||..:.......
  Rat   163 ELKQ------REELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEE---- 217

  Fly   228 TLLGSSLSTTNGTSRLGVSLDVAKASGSAAKEVSPESVAD-LVDLEQELTSLQRGISQMERITPN 291
                :.........:.|| .||.|:        .|.|.:. |.|.|          ::....|||
  Rat   218 ----NIYQVPTSQKKEGV-YDVPKS--------QPVSNSQPLEDFE----------ARFAAATPN 259

  Fly   292 EPTTSSTGGAGHPSL--------AKSASEDDPFGDSFIYVPSYSILPPPPDSGRNRHKPPNKTPD 348
                      |:.|:        .|:.::.:.|||          :..|||.    ..||  ||
  Rat   260 ----------GNLSMDFDELLEATKAVTQLELFGD----------MSTPPDI----TSPP--TP- 297

  Fly   349 AVTSLDAMLSPP----PGTSSSHGSASAGLQAADND--------DDNWLQE-LDQQNDVFDTSKV 400
             .|..||.|..|    ||::...||.|.|..|..:.        ...|.|: |.||.........
  Rat   298 -ATPGDAFLPAPSQTLPGSADVFGSMSFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQIAMGAQPP 361

  Fly   401 VSSSGLGSVLAMAPLASSESTATP-TQQLTEVAAGSGPLADLDIGLSTALGNEEQTSTILSLDAF 464
            |:....|:    .|:|..:....| |||.....||..|.|..           ..|.|::.|.|.
  Rat   362 VAQVIPGA----QPIAWGQPGLFPATQQPWPTVAGQFPPAAF-----------MPTQTVMPLPAA 411

  Fly   465 T---DLDPLGT-------GRTRPYVDKKYFFQELKNPPKKLLKELSSGSQAGLGLGLSLGQLDGL 519
            .   .|.||.|       .|:.|..||         |.:|:.||:....|......:...:.|
  Rat   412 MFQGPLTPLATVPGTNDSARSSPQSDK---------PRQKMGKEMFKDFQMAQPPPVPSRKPD-- 465

  Fly   520 FPEDSTTISTTTTTATNITAGNPQQN--------SANTLTSTASTAASLGQLLSTVALNPDPLPA 576
              :.|.|.::...::.....|..|..        |...||...||         |.:.|..|.||
  Rat   466 --QPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTST---------TPSTNSPPTPA 519

  Fly   577 P-ISIP--TSISHSITPSAE 593
            | .|.|  :|.||...|:|:
  Rat   520 PRQSSPSKSSASHVSDPTAD 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926	70/140 (50%)
Dab1	XP_017448664.1	PTB_Dab	25..174	CDD:269926	71/146 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334829
Domainoid	1	1.000	109	1.000	Domainoid score	I6225
eggNOG	1	0.900	-	-		E1_KOG3535
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002247
OrthoInspector	1	1.000	-	-		otm45486
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11232
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.840