DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dab and LDLRAP1

DIOPT Version :9

Sequence 1:	NP_001163455.2	Gene:	Dab / 39866	FlyBaseID:	FBgn0000414	Length:	2360	Species:	Drosophila melanogaster
Sequence 2:	NP_056442.2	Gene:	LDLRAP1 / 26119	HGNCID:	18640	Length:	308	Species:	Homo sapiens

Alignment Length:	330	Identity:	79/330 - (23%)
Similarity:	130/330 - (39%)	Gaps:	69/330 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SLASTFGGGSGAAEETNYAKHRNDPGRFFG------DGVQFKAKLIGILEVGEARGDRMCQEALQ 75
            |||....||.|        :||..|..:..      :|:.|..|.:|:..|.:.:|:.:...|::
Human    16 SLAKQSWGGGG--------RHRKLPENWTDTRETLLEGMLFSLKYLGMTLVEQPKGEELSAAAIK 72

  Fly    76 DLKMAIRAAGEHKQRITIHVTIDGLRLRDEKTGDSLYHHPVHKISFIAQDMTDSRAFGYIFGSPD 140
            .:....:|:|:..|::|:.|:..|:.|.|..|...:.:..:::||:...|....:.|.||..|..
Human    73 RIVATAKASGKKLQKVTLKVSPRGIILTDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQH 137

  Fly   141 SG----HRFFGIKTDKAASQVVLAMRDLFQVVFEL-----KKKEIEMARQQIQGKSLHDHSSQLA 196
            :.    |.|...|. |.|..|.|.:...|:|.||.     ::||......|..|..|........
Human   138 NQSLECHAFLCTKR-KMAQAVTLTVAQAFKVAFEFWQVSKEEKEKRDKASQEGGDVLGARQDCTP 201

  Fly   197 SLSSLKSSGLGGMGLGHSDLASGGISSGHALTLLGSSLSTTN-----------GTS---RLGVSL 247
            ||.||.::   |..|...:.|...:|:        .|.:|||           |:|   .|...|
Human   202 SLKSLVAT---GNLLDLEETAKAPLST--------VSANTTNMDEVPRPQALSGSSVVWELDDGL 255

  Fly   248 DVAKASGSAAKEVSPESVADLVDLEQELTSLQRGISQ-MERITPNEPTTSSTGGAGHPSLAKSAS 311
            |.| .|..|....:|:.      |:..||:.....:| :..:..::|.:|.|            .
Human   256 DEA-FSRLAQSRTNPQV------LDTGLTAQDMHYAQCLSPVDWDKPDSSGT------------E 301

  Fly   312 EDDPF 316
            :||.|
Human   302 QDDLF 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926	39/160 (24%)
LDLRAP1	NP_056442.2	PTB_LDLRAP-mammal-like	44..166	CDD:269981	30/122 (25%)
		Clathrin box. /evidence=ECO:0000269\|PubMed:12221107	212..216		1/3 (33%)
		AP-2 complex binding. /evidence=ECO:0000269\|PubMed:12221107	249..276		8/33 (24%)
		[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. /evidence=ECO:0000269\|PubMed:16516836	257..266		3/9 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141165
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840