Protein Alignment Dab and Numbl

DIOPT Version :9

• Sequence 1: NP_001163455.2
• Gene: Dab / 39866
• FlyBaseID: FBgn0000414
• Length: 2360
• Species: Drosophila melanogaster
• Sequence 2: XP_006539678.1
• Gene: Numbl / 18223
• MGIID: 894702
• Length: 608
• Species: Mus musculus
• Alignment Length: 711
• Identity: 155/711 - (21%)
• Similarity: 222/711 - (31%)
• Gaps: 259/711 - (36%)

  Fly    51 FKAKLIGILEVGEARGDRMCQEALQDLKMAIRAAGEHKQRITIHVTIDGLRLRDEKTGDSLYHHP 115
            |..:.:|.:||.|:||..:|::|::.||    |.|....:..:.|:.||||:.|:||.|.|....
Mouse    84 FPVRYLGHVEVEESRGMHVCEDAVKKLK----AMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQT 144

  Fly   116 VHKISFIAQDMTDSRAFGYIFGSPDSG----HRFFGIKTDKAASQVVLAMRDLFQVVFELKKKEI 176
            :.|:||.|.|....:||.||.....:.    |.|..:|  .:..::..|:...|....|
Mouse   145 IEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALK--DSGERLSHAVGCAFAACLE------ 201

  Fly   177 EMARQQIQGKSLHDHSSQLASLSSLKSSGLGGMGLGHSDLASGGISSGHALTLLGSSLSTTNGTS 241
               |:|.:.|.....::..||.:|....|        |...|||          |.......|
Mouse   202 ---RKQRREKECGVTAAFDASRTSFAREG--------SFRLSGG----------GRPAEREAG-- 243

  Fly   242 RLGVSLDVAKASGSAAKEVSPESVADLVDLEQELTSLQRGISQMERITPNEPTTS--STGGAGHP 304
                  |..||..:||..|:|                  |.:|...::|...|||  ..|.||.|
Mouse   244 ------DKKKAEAAAAPAVAP------------------GPAQPGHVSPTPATTSPGEKGEAGTP 284

  Fly   305 SLAKSASEDDP----------FGDSFIYVPSYSILPPP------------PDSGRNR-------- 339
            ..|.:.:...|          ...||...|:.|....|            |.:.:.|
Mouse   285 VAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGT 349

  Fly   340 ---HKPPNK-TPDAVTSLDAMLS------------PPPGT--SSSHGSASAGLQAA--------D 378
               .:||.. ..|.:.:|...:|            |||.|  :|:.|..|....||        .
Mouse   350 VPEMEPPGTGDSDGINALCTQISSSFASAGAPASGPPPATTGTSAWGEPSVPAAAAFQPGHKRTP 414

  Fly   379 NDDDNWLQELDQ----QNDVFDTSKVVSSSGLGSVLAMAPLASSESTATPTQQLTEVAAGSGPLA 439
            ::.:.||:|:.|    |.......:........||..|..:|       ||.|     ..|.|:.
Mouse   415 SEAERWLEEVSQVAKAQQQQQQQQQQQQQQQATSVPPMPTMA-------PTLQ-----PFSAPVG 467

  Fly   440 DLDIGLSTALGNEEQTSTILSLDAFTDLDPLGTGRTRPYVDKKYFFQELKNPPKKLLKELSSGSQ 504
            ..|...:       |.:..|..   |.:.|       |:|.                      :.
Mouse   468 PFDTAAA-------QVAVFLPP---THMQP-------PFVP----------------------AY 493

  Fly   505 AGLGLGLSLGQLDGLFPEDSTTISTTTTTATNITAGNPQQNSANTLTSTASTAASLGQLLSTVAL 569
            .|||           :|      .........||   |.|..||...|.|........||.....
Mouse   494 PGLG-----------YP------PMPRVPVVGIT---PSQMVANAFCSAAQLQPQPATLLGKAGA 538

  Fly   570 NPDPLPAPISIPTSISHSITPSAELKLLLGHVTNPPNPTGHYYTTEPPTLNSLENPHPPADPVLL 634
            .|.|     :.|::      |..:.:         |.|.|..:   ||      .|.|...|.|
Mouse   539 FPPP-----AAPSA------PGGQAR---------PRPNGAPW---PP------EPAPAPAPEL- 573

  Fly   635 PRDTDPFSPTRKKSDPDPFQESDLFAKLDAFEFEAPPAVPAPSIPNLATETKANVFNGPLQ 695
                            |||:..  :|.|     |..|||..||          |.|:|.||
Mouse   574 ----------------DPFEAQ--WAAL-----EGKPAVEKPS----------NPFSGDLQ 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926	38/133 (29%)
Numbl	XP_006539678.1	PTB_Numb	68..202	CDD:241298	38/132 (29%)
		PHA03247	<263..594	CDD:223021	90/464 (19%)
		NumbF	293..375	CDD:368837	13/81 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831097
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840