DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dab and DAB2

DIOPT Version :9

Sequence 1:	NP_001163455.2	Gene:	Dab / 39866	FlyBaseID:	FBgn0000414	Length:	2360	Species:	Drosophila melanogaster
Sequence 2:	NP_001334.2	Gene:	DAB2 / 1601	HGNCID:	2662	Length:	770	Species:	Homo sapiens

Alignment Length:	819	Identity:	218/819 - (26%)
Similarity:	345/819 - (42%)	Gaps:	207/819 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RFFGDGVQFKAKLIGILEVGEARGDRMCQEALQDLK---MAIRAAGEHKQRITIHVTIDGLRLRD 104
            ||.||||::|||||||.:|.:||||:|.|:::..||   .|.|:.|:|||||.:::::.|:::.|
Human    42 RFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIID 106

  Fly   105 EKTGDSLYHHPVHKISFIAQDMTDSRAFGYIFGSPDSGHRFFGIKTDKAASQVVLAMRDLFQVVF 169
            ||||...:.|||:||||||:|:||:|||||:.|. :..|:||.|||.:.|..:|:.::|||||::
Human   107 EKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGG-EGQHQFFAIKTGQQAEPLVVDLKDLFQVIY 170

  Fly   170 ELKKKEIEMARQQIQGKSLHDHSSQLASL----SSLKSSGLGGMGLGHSDLASGGISSGHALTLL 230
            .:||||.|..:.:...|::.:.|..|..|    :.|||      |:...|| .|.:|:...|.
Human   171 NVKKKEEEKKKIEEASKAVENGSEALMILDDQTNKLKS------GVDQMDL-FGDMSTPPDLN-- 226

  Fly   231 GSSLSTTNGTSRLGVSLDVAKASGSAAKEVSPESVADLVDLEQELTSLQRGISQMERITPNEPTT 295
                                  |.:.:|::.      ||||..|:.:.|..:.:...:| |..|:
Human   227 ----------------------SPTESKDIL------LVDLNSEIDTNQNSLRENPFLT-NGITS 262

  Fly   296 SSTGGAGHPSLAKSASEDDPFGDSFIYVPSYSILPPPPDSGRNR--HKPPNKTPDAVTSLDAMLS 358
            .|   ...|:...|...::.|..:..:.|:     |.||..|:.  .:|...||   :|.|::.|
Human   263 CS---LPRPTPQASFLPENAFSANLNFFPT-----PNPDPFRDDPFTQPDQSTP---SSFDSLKS 316

  Fly   359 P---PPGTSSSHGSASAGLQAADNDDDNWLQELDQ----------------------------QN 392
            |   ...:|||....|.|  ..:.|.|.:.|:.||                            ||
Human   317 PDQKKENSSSSSTPLSNG--PLNGDVDYFGQQFDQISNRTGKQEAQAGPWPFSSSQTQPAVRTQN 379

  Fly   393 DVFDTSKVVSSSGLGSVLAMAPLASSE----STATPTQQLTEVAAGSGP---LADLDIGLSTALG 450
            .|.:..:    :|.....:..|...|.    |.....:|..|.:..|.|   :|.:....||..|
Human   380 GVSEREQ----NGFSVKSSPNPFVGSPPKGLSIQNGVKQDLESSVQSSPHDSIAIIPPPQSTKPG 440

  Fly   451 NEEQT-----STILSLDAFTD--LDPLG----TGRTRPYVDKKYFFQELKNPPKKLLKELSSGSQ 504
            ...:|     :.:|:.|.|..  .:|.|    ||:.          ..|:..|..|.|   :.:.
Human   441 RGRRTAKSSANDLLASDIFAPPVSEPSGQASPTGQP----------TALQPNPLDLFK---TSAP 492

  Fly   505 AGLGLGLSLGQLDGLFPE------DSTTISTTTTTATN-ITAGNPQQNSANTLTSTASTAASLGQ 562
            |.:|..:.||.:....|:      .|...:.:.:.|.. :..|.|...|...:..|:...:...|
Human   493 APVGPLVGLGGVTVTLPQAGPWNTASLVFNQSPSMAPGAMMGGQPSGFSQPVIFGTSPAVSGWNQ 557

  Fly   563 LLSTVALNPDPL----PAPISIPTSISHSITPSAELKLLLGHVTNP----------PNPTGHYYT 613
                    |.|.    |.|:.:....|.|:.|:|      ...|:|          |.|.   .:
Human   558 --------PSPFAASTPPPVPVVWGPSASVAPNA------WSTTSPLGNPFQSNIFPAPA---VS 605

  Fly   614 TEPPTLNS---LENPHPP--ADPVLLPRD--TDPFSPTRKKSDPDPFQESDLFAKLDAFEFEAPP 671
            |:||:::|   :..|.||  |.|   |:|  :|.|:......|.:.....::|..   |:...||
Human   606 TQPPSMHSSLLVTPPQPPPRAGP---PKDISSDAFTALDPLGDKEIKDVKEMFKD---FQLRQPP 664

  Fly   672 AVPAPSIPNLATETK---ANVFNGPLQVQLPPE---------KEL--QLQQPPSTVRNRPTASVS 722
            ||||......::.|.   |:.||.  :|.:|.|         .:|  ::.:||     :|.....
Human   665 AVPARKGEQTSSGTLSAFASYFNS--KVGIPQENADHDDFDANQLLNKINEPP-----KPAPRQV 722

  Fly   723 ALPSGGALDVISSISNKKMPHLFGQARSFGKSGSDIGSS 761
            :||      |..|..|......|..  |||.|.:.:.||
Human   723 SLP------VTKSTDNAFENPFFKD--SFGSSQASVASS 753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926	72/140 (51%)
DAB2	NP_001334.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		PTB_Dab	35..172	CDD:269926	67/130 (52%)
		Required for localization to clathrin-coated pits. /evidence=ECO:0000250	230..447		52/240 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..482		46/221 (21%)
		DPF 1	293..295		1/1 (100%)
		DPF 2	298..300		0/1 (0%)
		Sufficient for interaction with GRB2. /evidence=ECO:0000250	604..732		37/146 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	604..629		9/27 (33%)
		Required for interaction with CSK. /evidence=ECO:0000250	619..627		3/7 (43%)
		Required for interaction with MYO6. /evidence=ECO:0000250	649..770		31/123 (25%)
		Required for interaction with GRB2 and CSK. /evidence=ECO:0000250	663..671		6/7 (86%)
		Sufficient for interaction with SH3KBP1 SH3 domain. /evidence=ECO:0000250	709..725		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..770		6/12 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6364
eggNOG	1	0.900	-	-		E1_KOG3535
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002247
OrthoInspector	1	1.000	-	-		otm41362
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11232
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2975
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.990