DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dab and DAB1

DIOPT Version :9

Sequence 1:NP_001163455.2 Gene:Dab / 39866 FlyBaseID:FBgn0000414 Length:2360 Species:Drosophila melanogaster
Sequence 2:NP_001340912.1 Gene:DAB1 / 1600 HGNCID:2661 Length:555 Species:Homo sapiens


Alignment Length:615 Identity:167/615 - (27%)
Similarity:253/615 - (41%) Gaps:160/615 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 RFFGDGVQFKAKLIGILEVGEARGDRMCQEALQDLKMAI---RAAGEHKQRITIHVTIDGLRLRD 104
            ||.|:||::|||||||.||..||||::||:::..||..:   |:.|||||:|.:.::..|:::.|
Human    34 RFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFD 98

  Fly   105 EKTGDSLYHHPVHKISFIAQDMTDSRAFGYIFGSPDSGHRFFGIKTDKAASQVVLAMRDLFQVVF 169
            ||||...:||.||:||:||:|:||.|||||:.|. :..|||..|||.:||..|:|.:|||||:::
Human    99 EKTGALQHHHAVHEISYIAKDITDHRAFGYVCGK-EGNHRFVAIKTAQAAEPVILDLRDLFQLIY 162

  Fly   170 ELKKKEIEMARQQIQGKSLHDHSSQLASLSSLKSSGLGG-------MGLGHSDLASGGISSGHAL 227
            |||:      |::::.|:..|...:.|...::....:..       ...||..:.......    
Human   163 ELKQ------REELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEE---- 217

  Fly   228 TLLGSSLSTTNGTSRLGVSLDVAKASGSAAKEVSPESVADLVDLEQELTSLQRGISQMERITPNE 292
                :.........:.|| .||.|:        .|.|....::|..:::            ||.:
Human   218 ----NIYQVPTSQKKEGV-YDVPKS--------QPVSAVTQLELFGDMS------------TPPD 257

  Fly   293 PTTSSTGGAGHPSLAKSASEDDPFGDSFIYVPSYSILPPPPDSGRNRHKPPNKTPDAVTSLDAML 357
            .|:..|     |:..         ||:||                     |:.:.....|.|...
Human   258 ITSPPT-----PATP---------GDAFI---------------------PSSSQTLPASADVFS 287

  Fly   358 SPPPGTS---SSHGSASAGLQAADNDDDNWLQE-LDQQNDVFDTSKVVSSSGLGSVLAMAPLASS 418
            |.|.||:   |.:.:..|.|.:.      |.|: |.||..|......|:....|:    .|:|..
Human   288 SVPFGTAAVPSGYVAMGAVLPSF------WGQQPLVQQQMVMGAQPPVAQVMPGA----QPIAWG 342

  Fly   419 ESTATP-TQQLTEVAAGSGPLADLDIGLSTALGNEEQTSTILSLDAFT---DLDPLGT------- 472
            :....| |||.....||..|.|..           ..|.|::.|.|..   .|.||.|       
Human   343 QPGLFPATQQPWPTVAGQFPPAAF-----------MPTQTVMPLPAAMFQGPLTPLATVPGTSDS 396

  Fly   473 GRTRPYVD-------KKYF--FQELKNPPKKLLK----ELSSGSQA------GLGLG-------- 510
            .|:.|..|       |:.|  ||..:.||....|    .|:..|:|      .:|:.        
Human   397 TRSSPQTDKPRQKMGKETFKDFQMAQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDD 461

  Fly   511 LSLGQLDGLFPEDSTTISTTTTTATNITAGNPQQNSANTLTSTA----------STAASLGQLL- 564
            ..:.||: |.|..|||.||.:.........:|.::||:..:...          |.:.|..|.. 
Human   462 FDISQLN-LTPVTSTTPSTNSPPTPAPRQSSPSKSSASHASDPTTDDIFEEGFESPSKSEEQEAP 525

  Fly   565 --STVALNPDPLPAPISIPTSISHSITPSA 592
              |..:.|.||...|...|:  ..:|:|.|
Human   526 DGSQASSNSDPFGEPSGEPS--GDNISPQA 553

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DabNP_001163455.2 PTB_Dab 35..181 CDD:269926 70/140 (50%)
DAB1NP_001340912.1 PTB_Dab 25..174 CDD:269926 71/146 (49%)
PHA03247 <235..437 CDD:223021 59/277 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141164
Domainoid 1 1.000 109 1.000 Domainoid score I6364
eggNOG 1 0.900 - - E1_KOG3535
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S7100
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002247
OrthoInspector 1 1.000 - - otm41362
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11232
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2975
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.780

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