DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dab and Dab2

DIOPT Version :9

Sequence 1:	NP_001163455.2	Gene:	Dab / 39866	FlyBaseID:	FBgn0000414	Length:	2360	Species:	Drosophila melanogaster
Sequence 2:	NP_075607.2	Gene:	Dab2 / 13132	MGIID:	109175	Length:	766	Species:	Mus musculus

Alignment Length:	888	Identity:	222/888 - (25%)
Similarity:	356/888 - (40%)	Gaps:	247/888 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RFFGDGVQFKAKLIGILEVGEARGDRMCQEALQDLK---MAIRAAGEHKQRITIHVTIDGLRLRD 104
            ||.||||::|||||||.:|.:||||:|.|:::..||   .|.|:.|:|||||.:::::.|:::.|
Mouse    42 RFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIID 106

  Fly   105 EKTGDSLYHHPVHKISFIAQDMTDSRAFGYIFGSPDSGHRFFGIKTDKAASQVVLAMRDLFQVVF 169
            ||||...:.|||:||||||:|:||:|||||:.|. :..|:||.|||.:.|..:|:.::|||||::
Mouse   107 EKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGG-EGQHQFFAIKTGQQAEPLVVDLKDLFQVIY 170

  Fly   170 ELKKKEIEMARQQIQGKSLHDHSSQLASL----SSLKSSGLGGMGLGHSDLASGGISSGHALTLL 230
            .:||||.:..:.:...|:..:.|..|.:|    :.||      :|:...|| .|.:|:...|.
Mouse   171 NVKKKEEDKKKVEEANKAEENGSEALMTLDDQANKLK------LGVDQMDL-FGDMSTPPDLN-- 226

  Fly   231 GSSLSTTNGTSRLGVSLDVAKASGSAAKEVSPESVADLVDLEQELTSLQRGISQMERITPNEPTT 295
                                  |.:.:|::.      ||||..|:.:.|..:.:...:| |..|:
Mouse   227 ----------------------SPTESKDIL------LVDLNSEIDTNQNSLRENPFLT-NGVTS 262

  Fly   296 SSTGGAGHPSLAKSASEDDPFGDSFIYVPSYSILPPPPDSGRNRHKPPNKTPD--AVTSLDAMLS 358
            .|   ...|....|...::.|..:..:.|:     |.||..|:   .|...||  |.:|.|::.|
Mouse   263 CS---LPRPKPQASFLPENAFSANLNFFPT-----PNPDPFRD---DPFAQPDQSAPSSFDSLTS 316

  Fly   359 PPPGTSSSHGSASAGLQAADNDDDNWL-QELDQQNDVFDTSKVVSSSGLGSVLAMAPLASSESTA 422
            |....:|...|::...:...|.|.::. |:.||.::  .|.|..:..|      ..|..||:
Mouse   317 PDQKKASLSSSSTPQSKGPLNGDTDYFGQQFDQLSN--RTGKPEAQGG------PWPYPSSQ--- 370

  Fly   423 TPTQQLTEVAAGSGPLADLDIGLSTALGNEEQTSTILSLDAFTDLDPLGTGRTRPYVDKKYFFQE 487
              |||......|              :...||....:.            ....|:|.
Mouse   371 --TQQAVRTQNG--------------VSEREQNGFHIK------------SSPNPFVG------- 400

  Fly   488 LKNPPKKL------LKELSSGSQAGLGLGLSLGQLDGLFPEDSTTIS----TTTTTATNITAGN- 541
              :|||.|      .::|.|..|:.....:::     :.|..||...    |..::|.::.|.:
Mouse   401 --SPPKGLSVPNGVKQDLESSVQSSAHDSIAI-----IPPPQSTKPGRGRRTAKSSANDLLASDI 458

  Fly   542 -----------------PQQNSANTLTSTASTAASLGQL--LSTVALNP------DPL---PAPI 578
                             ||.|..:.....|  .|.:|.|  |.||.:.|      .|:   |:..
Mouse   459 FASEPPGQMSPTGQPAVPQSNFLDLFKGNA--PAPVGPLVGLGTVPVTPPQAGPWTPVVYSPSTT 521

  Fly   579 SIPTSISHSITPSAELKLLLGHVTNPPNPTGHYYTTEPPTLNSLENPHPPADPVLLPRDTDPFSP 643
            .:|.:|.....||....|:.|  |.|.....:    :.|:..:..:|.||.  |..|  |...:|
Mouse   522 VVPGAIISGQPPSFGQPLVFG--TTPAVQVWN----QSPSFATPASPPPPT--VWCP--TTSVAP 576

  Fly   644 TRKKSDP---DPFQESDLFAKLDAFEFEAPPAVPAPSIPN------LATETKANVFNGPLQVQLP 699
            ....|..   :|||.:::|         .||.:...|.|.      |||..:....||||: .:|
Mouse   577 NAWSSTSPLGNPFQSNNIF---------PPPTMSTQSSPQPMMSSVLATPPQPPPRNGPLK-DIP 631

  Fly   700 PE--------------------KELQLQQPPSTVRNRPTASVSALPSGGALDVISSISNKKM--- 741
            .:                    |:.||:|||..    |:......|||.: ...||..|.|:
Mouse   632 SDAFTGLDPLGDKEVKEVKEMFKDFQLRQPPLV----PSRKGETPPSGTS-SAFSSYFNNKVGIP 691

  Fly   742 -PHLFGQARSFGKSGSDIGSSVNMRRLQESDSLSETEAAPEPPPRPDSTPYSEPPPLPPKKQFSD 805
             .|:         ...|..::..:.::.|                         ||.|..:| ..
Mouse   692 QEHV---------DHDDFDANQLLNKINE-------------------------PPKPAPRQ-GV 721

  Fly   806 LVIRPSPANTTQPPTSGRYEYLNSNVTARRTASSVDAPPIPLP 848
            |:...|..|:.:.|.|..:...|.:|.::..:|.....|...|
Mouse   722 LLGTKSADNSLENPFSKGFSSSNPSVVSQPASSDPHRSPFGNP 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dab	NP_001163455.2	PTB_Dab	35..181	CDD:269926	71/140 (51%)
Dab2	NP_075607.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		PTB_Dab	35..171	CDD:269926	67/129 (52%)
		Required for localization to clathrin-coated pits	230..447		59/287 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..482		50/258 (19%)
		PHA03247	<288..608	CDD:223021	85/401 (21%)
		DPF 1	293..295		1/1 (100%)
		DPF 2	298..300		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..630		11/34 (32%)
		Sufficient for interaction with GRB2. /evidence=ECO:0000269\|PubMed:9569023	600..730		33/170 (19%)
		Required for interaction with CSK. /evidence=ECO:0000250	617..625		0/7 (0%)
		Required for interaction with MYO6. /evidence=ECO:0000269\|PubMed:11906161	647..766		31/158 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	659..683		8/28 (29%)
		Required for interaction with GRB2 and CSK. /evidence=ECO:0000250	661..669		3/11 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..766		16/92 (17%)
		Sufficient for interaction with SH3KBP1 SH3 domain	707..723		5/41 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831108
Domainoid	1	1.000	109	1.000	Domainoid score	I6358
eggNOG	1	0.900	-	-		E1_KOG3535
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002247
OrthoInspector	1	1.000	-	-		otm43419
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11232
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2975
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.920