DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lasp and BOI1

DIOPT Version :9

Sequence 1:	NP_730192.2	Gene:	Lasp / 39864	FlyBaseID:	FBgn0063485	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_009468.1	Gene:	BOI1 / 852193	SGDID:	S000000181	Length:	980	Species:	Saccharomyces cerevisiae

Alignment Length:	723	Identity:	129/723 - (17%)
Similarity:	246/723 - (34%)	Gaps:	193/723 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EELKCLDKTWHKTCFKCTECGMTLNMKTYKGYNKMPYCEAHIPKAKATAIADTPELKRIAENTKI 80
            |:.:..:.|.|.:.|..| ..:.|:.::.|..:|              :...|..|:..:|:.:
Yeast   170 EKTRNEENTTHDSLFSST-ADLNLSSESLKNISK--------------SNISTKSLEPSSESVR- 218

  Fly    81 QSNVKYHADF--EKAKGKFTQVADDPET------------LRIKQNTKHISNVAYHGDLEKKAAM 131
            |.::|....:  |:....|:.|..|..|            :.::...:|:..:..:....:....
Yeast   219 QLDLKMAKSWSPEEVTDYFSLVGFDQSTCNKFKEHQVSGKILLELELEHLKELEINSFGIRFQIF 283

  Fly   132 EKQRGSAEVSDSSNESEYFSEQLAAEQFSQYA--PTASPIPPAATTLHQQQQQLQHQQQQQYQQH 194
            ::.|......|||      |.:|.|: :|.:|  ..|:.:.||||.                  :
Yeast   284 KEIRNIKSAIDSS------SNKLDAD-YSTFAFENQAAQLMPAATV------------------N 323

  Fly   195 QQQLQQQQHQHQHYLQQQQQTLPPPPI--QHQQYNTAAITPTYQQLQQQQQQQQQQRAQQQQLHD 257
            :.::|||.....:.|..:........:  :.|:.::..:.|.:                  :|||
Yeast   324 RDEIQQQISSKCNKLSSESSDRKSSSVTTELQRPSSVVVNPNF------------------KLHD 370

  Fly   258 PYAHYQQPQALRQQQQQQQQQQQQLLQQQAIKQASHLYPTATSQQQQMPPPQSPA---------- 312
            |           .:|.....:...|...:.|.::....|...|....:.|||||:
Yeast   371 P-----------AEQILDMTEVPNLFADKDIFESPGRAPKPPSYPSPVQPPQSPSFNNRYTNNNA 424

  Fly   313 -NPQQQALNSYNE----MRSAILQNSHHPSGNSVDQYDQPQQQQHQPQQQS---TNPTLVAAQQQ 369
             .|.|......|:    ..:.::.||...|.||..::..|....|....:.   |:.|:.:....
Yeast   425 RFPPQTTYPPKNKNPTVYSNGLIPNSSTSSDNSTGKFKFPAMNGHDSNSRKTTLTSATIPSINTV 489

  Fly   370 QSHHSL--LNNNASNGGISHSHHSNINN---NGH-----GS-------QNQMLPP---------Q 408
            .:..||  ::|.:||   :.|||.|.|:   |.|     ||       :..||.|         .
Yeast   490 NTDESLPAISNISSN---ATSHHPNRNSVVYNNHKRTESGSSFVDLFNRISMLSPVKSSFDEEET 551

  Fly   409 MRRSAASVVAYD--------GNSKQQVAAGPGAAQNH-----LQQLYASPNYAAVT-PSENSINV 459
            .:.|.||...:|        |:|:.   |.....:.|     :...::|.:.:..| |::.:..:
Yeast   552 KQPSKASRAVFDSARRKSSYGHSRD---ASLSEMKKHRRNSSILSFFSSKSQSNPTSPTKQTFTI 613

  Fly   460 KQHASNGHMPNQQQQHVAGGSNIGKIADYDPLTDGP---RVVPNAGRSSTTLVYSSEPRGNQGGN 521
            .......|..:|...:....|.....:....|...|   .:.|...:|:..|.:|..|..:....
Yeast   614 DPAKMTSHSRSQSNSYSHARSQSYSHSRKHSLVTSPLKTSLSPINSKSNIALAHSETPTSSNNKE 678

  Fly   522 SVYPKRIGSVSDIDPANGIYGSLTAAEQAHQQQKHQQYYQQVQMMQQQEHPPQQQQMRQQPSYSS 586
            :|          ..|:.|        :..| :.||:..::.   ..........::..::..:||
Yeast   679 AV----------SQPSEG--------KHKH-KHKHKSKHKH---KNSSSKDGSSEEKSKKKLFSS 721

  Fly   587 LQE--------KQSRQSTAMRVYRAIYD-YEAQDVDEVSFREG-DVIFEVESID----SGWMTGR 637
            .:|        |:|......:..::|.. ..|:.....:|.|| ..|...||:.    ||||:.:
Yeast   722 TKESFVGSKEFKRSPSELTQKSTKSILPRSNAKKQQTSAFTEGIRSITAKESMQTADCSGWMSKK 786

  Fly   638 VERTGKTG 645
              .||..|
Yeast   787 --GTGAMG 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lasp	NP_730192.2	LIM_LASP	5..57	CDD:188831	8/40 (20%)
		Nebulin	68..94	CDD:279252	6/27 (22%)
		NEBU	97..127	CDD:128523	5/41 (12%)
		SH3_Nebulin_family_C	600..654	CDD:212723	15/52 (29%)
BOI1	NP_009468.1	SH3_BOI	17..71	CDD:212819
		SAM_superfamily	226..290	CDD:417767	7/63 (11%)
		PH_Boi	778..894	CDD:270126	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960