DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lasp and nrap

DIOPT Version :9

Sequence 1:	NP_730192.2	Gene:	Lasp / 39864	FlyBaseID:	FBgn0063485	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	XP_021335836.1	Gene:	nrap / 724004	ZFINID:	ZDB-GENE-060616-224	Length:	1862	Species:	Danio rerio

Alignment Length:	829	Identity:	159/829 - (19%)
Similarity:	279/829 - (33%)	Gaps:	255/829 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MN-KTCARCQKVVYPIEELKCLDKTWHKTCFKCTECGMTLNMKTYKGYNKMPYCEAHIPKAKA-T 63
            || :.||||..||||.|::..:.:.|||.||.|..|.|.|....|..:.|.|||:.|.||... |
Zfish     1 MNVQKCARCGFVVYPAEKVNLIGQNWHKACFHCEVCKMVLTANNYVSHQKRPYCQVHNPKNNTFT 65

  Fly    64 AIADTP----------------------------------------------------------- 69
            ::.:||
Zfish    66 SVYETPVNINAKKQSEAVSENKYKEEGERFMSTFHYDMRSKEIEQARKASQLASQQQGYQTEFVG 130

  Fly    70 ------------ELKRIAENTKIQSNVKYHADFEKAKGKFTQVADDPETLRIKQNTKHISNVAYH 122
                        |:.|:::..|..|:|:|....|....:||.|||.||.|..|......|:|.|.
Zfish   131 QQSFYSGSVTSQEIVRVSQTQKTISDVEYKRGHETRMLQFTSVADSPEVLHAKTGVSLASDVKYT 195

  Fly   123 GDLEKKAAMEKQRGS--------AEVSDSSN----ESEYFSEQLAAEQFSQYAPTASPIPPAATT 175
            .:.|:    .|.:||        .|::..:|    ..||  ::...|:.|:|. |.:..|.....
Zfish   196 EEYEQ----SKGKGSFPAMITPGYEMAKKANTLASNLEY--KKGHEERVSKYT-TVTDTPDVLLA 253

  Fly   176 LHQQQQQLQHQQQQQYQQHQQQLQQQQHQHQHYLQQQQQTLPPPPIQHQQYNTAAITPTYQ---- 236
            ..|.:....|...:.|:|                |:.:.:.|           |..||.||
Zfish   254 KTQGKIVSDHVYTEGYEQ----------------QRGKGSFP-----------AHFTPGYQVAKK 291

  Fly   237 --------QLQQQQQQQQQQRAQQQQLHDPYA-------HYQQPQALRQQQQQQQQQQQQLL--- 283
                    :.||:.:|:.:.:|..:.....:|       |:.|.....:.:||:.:.....:
Zfish   292 AGDMASKVKYQQKYEQEIKGKASTEAGAAEFALAKENAEHFSQHAYTEEYEQQRGKGSFPAMITP 356

  Fly   284 -QQQAIK-----------------QASHLYPTATSQQQQMPPPQSPANPQQQALNSYNEMRSAI- 329
             .|.|.|                 :.|..|.|.|::.          |...::....|::.|.:
Zfish   357 GYQMAKKAHDIASDLKYKKDFNKMKGSSAYHTLTTED----------NLALKSARKINKLMSEVE 411

  Fly   330 -LQNSHHPSGNSVDQYDQPQQQQHQPQQQSTNPTLVAAQQQQSHHSLLNNNASNGGISHS--HHS 391
             .::.....|:|::..:.||.:......:.|:..    :.::::.:.:..:...|||...  |..
Zfish   412 YKKDLETTKGHSINYCETPQFKNVSKIAKYTSDN----KYKENYTNHMKGHYEGGGIDKKTMHAM 472

  Fly   392 NI---------------NNNGHGSQN--QMLPPQMRRSAASVVAYDGNSKQ--------QVAAGP 431
            |:               ..|..|..|  ..:.|..:.........|.|.:|        ||...|
Zfish   473 NVRKLASDISYKSEYEQEKNVQGEYNYPANITPSYQSQKKLEPLKDKNYRQHIDKLKFSQVTDTP 537

  Fly   432 GAAQ-----NHLQQLYASPNY----AAVTPSENSINVKQHASNGHMPNQQQQHVAGGSNIGKIAD 487
            ...|     :.|..|....||    ...|.|::...:|:..:|..:.:..:.......|..|..:
Zfish   538 EIVQARINAHQLSDLNYKANYEKTKTQYTLSQDMPELKKAKANAELVSDIKYKEDWEKNKSKACE 602

  Fly   488 --YDPLTDGPRVVPNAGRSSTTLVYSSEPRGNQGGNSVYPKRIG-SVSDIDPANGIYGSLTAAEQ 549
              .|.||      ..|.::|..|  :|:.:..:.......|.|| .|||....:.:..:..::|.
Zfish   603 IGLDTLT------LKAAKASRDL--ASDIKYKESYTKNKDKAIGMDVSDSKTLHSLQVAKLSSEV 659

  Fly   550 AHQQQKHQQYYQQVQMMQQQEHPPQQQQMRQQPSYSSLQEKQSRQSTA--MRVYRAIYDYEAQDV 612
            |:::...:        .|.:.|.||..        .:|...:..|:.|  :...:.::||....
Zfish   660 AYKKDSKE--------TQSKCHLPQDM--------VNLSHAKKAQALASDLEYRKKLHDYTLLS- 707

  Fly   613 DEVSFREGDVIFEVES-----IDSGWMTG---------RVERTGKTGML 647
            |::..::....::::|     .|..||.|         .||:..|.|.|
Zfish   708 DDMKVQQAKKAYKLQSDNQYRSDLNWMKGVGWEADGCLDVEQAKKAGEL 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lasp	NP_730192.2	LIM_LASP	5..57	CDD:188831	23/51 (45%)
		Nebulin	68..94	CDD:279252	9/96 (9%)
		NEBU	97..127	CDD:128523	12/29 (41%)
		SH3_Nebulin_family_C	600..654	CDD:212723	13/62 (21%)
nrap	XP_021335836.1	LIM_N_RAP	6..58	CDD:188830	23/51 (45%)
		NEBU	170..200	CDD:128523	12/29 (41%)
		Nebulin	355..379	CDD:307158	3/23 (13%)
		Nebulin	535..560	CDD:307158	6/24 (25%)
		NEBU	565..595	CDD:128523	4/29 (14%)
		NEBU	672..702	CDD:128523	6/37 (16%)
		NEBU	703..733	CDD:128523	4/30 (13%)
		NEBU	771..798	CDD:128523
		NEBU	1014..1044	CDD:128523
		NEBU	1158..1188	CDD:128523
		NEBU	1257..1287	CDD:128523
		NEBU	1292..1321	CDD:128523
		NEBU	1401..1430	CDD:128523
		NEBU	1644..1674	CDD:128523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1702
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810