Protein Alignment Lasp and Lima1

DIOPT Version :10

• Sequence 1: NP_730192.2
• Gene: Lasp / 39864
• FlyBaseID: FBgn0063485
• Length: 657
• Species: Drosophila melanogaster
• Sequence 2: NP_001107017.1
• Gene: Lima1 / 65970
• MGIID: 1920992
• Length: 753
• Species: Mus musculus
• Alignment Length: 150
• Identity: 37/150 - (24%)
• Similarity: 61/150 - (40%)
• Gaps: 36/150 - (24%)

  Fly     3 KTCARCQKVVYPIEELKCLDKTWHKTCFKCTECGMTLNMKTYKGYNKMPYCEAHIPKAKATAIAD 67
            ::|..|||.|||:|.|....:.:|.:||:|:.|...|::.||...:...||:.|.
Mouse   386 ESCVECQKTVYPMERLLANQQVFHISCFRCSYCNNKLSLGTYASLHGRIYCKPHF---------- 440

  Fly    68 TPELKRIAENTKIQSNVKYHADF--EKAKGKFTQVADDPETL-RIKQ-----NTKHISNV----- 119
                     |...:|...|...|  ::.|..:...:|:.||| |..|     .:.|...|
Mouse   441 ---------NQLFKSKGNYDEGFGHKQHKDLWASKSDNEETLGRPAQPPNAGESPHSPGVEDAPI 496

  Fly   120 ----AYHGDLEKKAAMEKQR 135
                .....:|.||:.:::|
Mouse   497 AKVGVLAASMEAKASSQRER 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lasp	NP_730192.2	LIM_LASP	5..57	CDD:188831	19/51 (37%)
		Nebulin	67..94	CDD:459977	4/28 (14%)
		NEBU	97..127	CDD:128523	8/44 (18%)
		SH3_Nebulin_family_C	600..654	CDD:212723
Lima1	NP_001107017.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	46..66
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	82..186
		Required for interaction with NPC1L1. /evidence=ECO:0000269|PubMed:29880681	164..166
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	276..326
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..379
		LIM_Eplin_alpha_beta	388..440	CDD:188869	19/51 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	467..493		8/25 (32%)
		Required for interaction with MYO5B. /evidence=ECO:0000269|PubMed:29880681	491..511		3/19 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	505..669		3/11 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	682..703