Protein Alignment Lasp and NEB

DIOPT Version :9

• Sequence 1: NP_730192.2
• Gene: Lasp / 39864
• FlyBaseID: FBgn0063485
• Length: 657
• Species: Drosophila melanogaster
• Sequence 2: NP_001258137.2
• Gene: NEB / 4703
• HGNCID: 7720
• Length: 8560
• Species: Homo sapiens
• Alignment Length: 802
• Identity: 179/802 - (22%)
• Similarity: 296/802 - (36%)
• Gaps: 244/802 - (30%)

  Fly    40 NMKTYKGYNK-----MPYCEAHIPKAKATAIADTPELKRIAENTKIQSNVKYHADFEKAKGKFTQ 99
            |:.:.|.|.:     |.|.|         .:.||||::|:.||.|..|.::|..|.:.:|||.|.
Human  7813 NLSSQKKYKEDAEKSMSYYE---------TVLDTPEIQRVRENQKNFSLLQYQCDLKNSKGKITV 7868

  Fly   100 VADDPETLRIKQNTKHISNVAYHGDL--------------------------------------- 125
            |.|.||.||:|:|.|:.|:|.|..|:
Human  7869 VQDTPEILRVKENQKNFSSVLYKEDVSPGTAIGKTPEMMRVKQTQDHISSVKYKEAIGQGTPIPD 7933

  Fly   126 --EKKAAMEKQRGSAEVSDSSN------------------ESEYFSEQLAAEQFSQYAPTASPIP 170
              |.|...|.|:..:.|....|                  ..|.||..|..|...:..||  ||.
Human  7934 LPEVKRVKETQKHISSVMYKENLGTGIPTTVTPEIERVKRNQENFSSVLYKENLGKGIPT--PIT 7996

  Fly   171 PAATTLHQQQQQLQHQQQQQY-----------QQHQQQLQQQQHQHQHYLQQQQQTLPPP----- 219
            |....:.:.|:.......::.           :..:.:|.|:......|.:...:.:|.|
Human  7997 PEMERVKRNQENFSSILYKENLSKGTPLPVTPEMERVKLNQENFSSVLYKENVGKGIPIPITPEM 8061

  Fly   220 -PIQHQQYNTAA--------------ITPTYQQLQQQQQQ-------------------QQQQRA 250
             .::|.|.|.::              |||..|:::..|:.                   .:.:|.
Human  8062 ERVKHNQENFSSVLYKENLGTGIPIPITPEMQRVKHNQENLSSVLYKENMGKGTPLPVTPEMERV 8126

  Fly   251 QQQQLHDPYAHYQQ------PQALRQQQQQQQQQQQQLLQQQAIKQASHLY--------PTA-TS 300
            :..|.:.....|::      |..:..:.::.:..|:.:        :|.||        |.| |.
Human  8127 KHNQENISSVLYKENMGKGTPLPVTPEMERVKHNQENI--------SSVLYKENMGKGTPLAVTP 8183

  Fly   301 QQQQMPPPQ-----------------SPANPQQQALNSYNEMRSAILQNSHHPSGNSVDQYDQPQ 348
            :.:::...|                 :|..|:.|.:....|..|::|...:  .|.:......|:
Human  8184 EMERVKHNQENISSVLYKENVGKATATPVTPEMQRVKRNQENISSVLYKEN--LGKATPTPFTPE 8246

  Fly   349 QQQHQPQQQS------------TNPTLVAAQQQQSHHSLLNNNASNGGISHSHHSNINNNGHGSQ 401
            .::.:..|::            ..||.|..:.:::..:  ..|.|:...|.|....|    .|..
Human  8247 MERVKRNQENFSSVLYKENMRKATPTPVTPEMERAKRN--QENISSVLYSDSFRKQI----QGKA 8305

  Fly   402 NQML-PPQMRR-----SAASVVAYDGNSKQQ------VAAGP--GAAQNHLQQLYASPNYAAVTP 452
            ..:| .|:|||     ...|.|.|..:.::.      |...|  ...:.::|. ::..||..:..
Human  8306 AYVLDTPEMRRVRETQRHISTVKYHEDFEKHKGCFTPVVTDPITERVKKNMQD-FSDINYRGIQR 8369

  Fly   453 SENSINVKQHASNGHMPNQQQQHVAG----GSNIGKIADYDPLTDGPR------VVPNAGRSSTT 507
            ....:..|::       :|.|:.:.|    .:|.|.:.||||..|..:      :...|.|.|..
Human  8370 KVVEMEQKRN-------DQDQETITGLRVWRTNPGSVFDYDPAEDNIQSRSLHMINVQAQRRSRE 8427

  Fly   508 LVYSSEPRGNQGG-----NSVYP-KRIGSVSDIDPANGIYGSLTAAEQAHQQQKHQQYYQQVQMM 566
            ...|:......||     :|..| ..:.:.||    .|::...||.:.|...:..||....|
Human  8428 QSRSASALSISGGEEKSEHSEAPDHHLSTYSD----GGVFAVSTAYKHAKTTELPQQRSSSV--- 8485

  Fly   567 QQQEHPPQQQQMRQQPSYSSLQEKQSRQSTAMRVYRAIYDYEAQDVDEVSFREGDVIFEVESIDS 631
                       ..||.:.||:   .|..|||.:::||:|||.|.|.|||||::||.|..|::||.
Human  8486 -----------ATQQTTVSSI---PSHPSTAGKIFRAMYDYMAADADEVSFKDGDAIINVQAIDE 8536

  Fly   632 GWMTGRVERTGKTGMLPANYVE 653
            |||.|.|:|||:||||||||||
Human  8537 GWMYGTVQRTGRTGMLPANYVE 8558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lasp	NP_730192.2	LIM_LASP	5..57	CDD:188831	6/21 (29%)
		Nebulin	68..94	CDD:279252	10/25 (40%)
		NEBU	97..127	CDD:128523	14/70 (20%)
		SH3_Nebulin_family_C	600..654	CDD:212723	36/54 (67%)
NEB	NP_001258137.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9133
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.870