Protein Alignment Lasp and LASP1

DIOPT Version :10

• Sequence 1: NP_730192.2
• Gene: Lasp / 39864
• FlyBaseID: FBgn0063485
• Length: 657
• Species: Drosophila melanogaster
• Sequence 2: NP_006139.1
• Gene: LASP1 / 3927
• HGNCID: 6513
• Length: 261
• Species: Homo sapiens
• Alignment Length: 654
• Identity: 144/654 - (22%)
• Similarity: 179/654 - (27%)
• Gaps: 396/654 - (60%)

  Fly     1 MNKTCARCQKVVYPIEELKCLDKTWHKTCFKCTECGMTLNMKTYKGYNKMPYCEAHIPKAKATAI 65
            ||..||||.|:|||.|::.||||.|||.||.|..|.||||||.||||.|.|||.||.||...|.:
Human     1 MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMV 65

  Fly    66 ADTPELKRIAENTKIQSNVKYHADFEKAKGK-FTQVADDPETLRIKQNTKHISNVAYHGDLEKKA 129
            |||||..|:.:.:::||.|:|..:|||.||| |:.|||.||..|||:....|||:.||.:.||
Human    66 ADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVADTPELQRIKKTQDQISNIKYHEEFEK-- 128

  Fly   130 AMEKQRGSAEVSDSSNESEYFSEQLAAEQFSQYAPTASPIPPAATTLHQQQQQLQHQQQQQYQQH 194
                                          |:..|:..           :..:.:.:..|....:
Human   129 ------------------------------SRMGPSGG-----------EGMEPERRDSQDGSSY 152

  Fly   195 QQQLQQQQHQHQHYLQQQQQTLPPPPIQHQQYNTAAITPTYQQLQQQQQQQQQQRAQQQQLHDPY 259
            ::.|:|||..|          :|          |:|  |.|||.|||...|.            |
Human   153 RRPLEQQQPHH----------IP----------TSA--PVYQQPQQQPVAQS------------Y 183

  Fly   260 AHYQQPQALRQQQQQQQQQQQQLLQQQAIKQASHLYPTATSQQQQMPPPQSPANPQQQALNSYNE 324
            ..|::|.|
Human   184 GGYKEPAA--------------------------------------------------------- 191

  Fly   325 MRSAILQNSHHPSGNSVDQYDQPQQQQHQPQQQSTNPTLVAAQQQQSHHSLLNNNASNGGISHSH 389
                                                                             
Human   192 ----------------------------------------------------------------- 191

  Fly   390 HSNINNNGHGSQNQMLPPQMRRSAASVVAYDGNSKQQVAAGPGAAQNHLQQLYASPNYAAVTPSE 454
                            |..::|||                 ||
Human   192 ----------------PVSIQRSA-----------------PG---------------------- 201

  Fly   455 NSINVKQHASNGHMPNQQQQHVAGGSNIGKIADYDPLTDGPRVVPNAGRSSTTLVYSSEPRGNQG 519
                                                                            |
Human   202 ----------------------------------------------------------------G 202

  Fly   520 GNSVYPKRIGSVSDIDPANGIYGSLTAAEQAHQQQKHQQYYQQVQMMQQQEHPPQQQQMRQQPSY 584
            |.    ||
Human   203 GG----KR--------------------------------------------------------- 206

  Fly   585 SSLQEKQSRQSTAMRVYRAIYDYEAQDVDEVSFREGDVIFEVESIDSGWMTGRVERTGKTGMLPA 649
                            |||:|||.|.|.|||||::||.|..|:.||.|||.|.|||||.||||||
Human   207 ----------------YRAVYDYSAADEDEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPA 255

  Fly   650 NYVE 653
            ||||
Human   256 NYVE 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lasp	NP_730192.2	LIM_LASP	5..57	CDD:188831	35/51 (69%)
		Nebulin	67..94	CDD:459977	12/26 (46%)
		NEBU	97..127	CDD:128523	14/29 (48%)
		SH3_Nebulin_family_C	600..654	CDD:212723	38/54 (70%)
LASP1	NP_006139.1	LIM_LASP	5..57	CDD:188831	35/51 (69%)
		Nebulin 1	61..95		14/33 (42%)
		Nebulin	67..94	CDD:459977	12/26 (46%)
		Nebulin 2	97..131		17/65 (26%)
		NEBU	98..128	CDD:128523	14/29 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..186		28/151 (19%)
		SH3_Lasp1_C	203..261	CDD:212867	41/134 (31%)