Protein Alignment Lasp and CAP

DIOPT Version :10

• Sequence 1: NP_730192.2
• Gene: Lasp / 39864
• FlyBaseID: FBgn0063485
• Length: 657
• Species: Drosophila melanogaster
• Sequence 2: NP_001369075.1
• Gene: CAP / 36084
• FlyBaseID: FBgn0033504
• Length: 2568
• Species: Drosophila melanogaster
• Alignment Length: 936
• Identity: 158/936 - (16%)
• Similarity: 270/936 - (28%)
• Gaps: 415/936 - (44%)

  Fly   113 TKHISNVAYHGDLEKKAAMEKQ-----------------RGSAEVSDSSNESEYFSEQLAAEQFS 160
            :::.:::.|..::.:..|.|.:                 |.||..:|.|:.|:|     :.:.|:
  Fly  1451 SRYANDLGYSENIARPFAREVEICYQRQNQRTPHCIRAPRLSASTNDLSSSSQY-----SYDTFN 1510

  Fly   161 QY------APT-----------------------------------ASPIPPAATTLHQQQ---- 180
            .|      ||.                                   .||.||...|..|||
  Fly  1511 AYGGRRTHAPMLNQAQQQQRPHYGSCYSMIERDPNPRYISTTSRRGVSPAPPPVATPQQQQVPPP 1575

  Fly   181 --QQLQHQQQQQYQQHQQQLQ-------------QQQHQHQHYLQQQQQTLP--PPPIQHQQYNT 228
              .:.|.:.....:.|:|||:             ::..|.:..|.::.|..|  |.|.:.:.|..
  Fly  1576 AYDRQQRRSSLPRELHEQQLKYILSKEEELKFEVERLQQERRRLMEEMQRAPVLPAPQRRESYRP 1640

  Fly   229 AAITPTY-------QQLQQQQQQQQQQRAQQQQ--------LHDPYAH----------------- 261
            ||..||.       ||:.::...:..:|.:::|        :.|.:.|
  Fly  1641 AAKLPTLSEDEVFRQQMAEEWMNKVAEREERRQHKIIRISKIEDEHDHSAVDKATISDEFLDRVK 1705

  Fly   262 ------------------YQQPQALRQQQ------------------------------------ 272
                              ..|||...|.|
  Fly  1706 ERRHKLSMPADSDWESGAESQPQPAAQSQPESDVEAPPVRILEGQAEANLRQLPRHLREFAKFST 1770

  Fly   273 --------QQQQQQQQQLLQQ-------------------------------------------- 285
                    |.::.::|:..::
  Fly  1771 SEQLPDGAQMERHEEQERREEATDNAHSSATKKTSIVKTYKVSRLPPSVQGEFPGQFSGGNRGRL 1835

  Fly   286 -----QAIKQASHLYP------------------------TATSQQQQM-----------PPPQS 310
                 |..:..||..|                        ..:|.|..:           |||..
  Fly  1836 YRERSQTARLVSHNIPLELTSNHSSSPDSDFNPGCGSSPAPGSSTQSSIPSLVQSPTPAPPPPIE 1900

  Fly   311 PANPQQQA---------------LNSYNEMRSAILQNSHHPSGNSVDQYDQPQQQQHQPQQQ--- 357
            |.||....               |.::|:.   |.:..|..........|:|::.....::|
  Fly  1901 PLNPSSSTAGGILGTALLLGLSLLTAWNKF---IYKVKHEYMSEPETGSDRPRKMAQLGRRQYDG 1962

  Fly   358 ---STN---PTLVAAQQQQSH------------HSLLNNN---------------ASNGGISH-- 387
               .||   |.::.::.::.|            |...|.:               .|||.:|.
  Fly  1963 IGPVTNDGMPIILRSEVKEPHQHEWYKRLYQTIHKQKNGDDFVIRYKCPRARPSYKSNGYVSEPE 2027

  Fly   388 -SHHSNINNNGHGSQNQMLPPQMRRSAASVVAYDGNSKQQVAAG----------------PGAAQ 435
             ::.|:.:...:.:||    |...:|.:|.|.....::.:...|                ||..:
  Fly  2028 PNYDSDYSTVRYRTQN----PHRVQSVSSAVNVRNLNQDEKLYGTMPNPIKSAQNSYKNQPGRIE 2088

  Fly   436 NH--------------------------LQQLYASPNY------------AAVTPSENSINVKQH 462
            |:                          |:|...||.|            :..|...|.:..|:.
  Fly  2089 NYTTGHSSVSEKEKKEWWDEVMDIFNGNLEQSKLSPLYTEGNLSRALAKESGYTSDSNLVFRKKE 2153

  Fly   463 --ASNGHMPNQQQQHV----AGGSN--IG-------KIADYDPLTDGPRVVPN---AGRSSTTLV 509
              .|:...|.:|:|..    |||..  :|       |..|.||  :.|.:.|.   .|.||....
  Fly  2154 VPVSSPLSPVEQKQAYKSLQAGGEPPLLGFRKPAPEKPRDLDP--NAPPIPPQPPVKGLSSYDFP 2216

  Fly   510 YSSEPRGNQGGNSVYPKRIGSVSDIDPANGIYGSLTAAEQAHQQQK--HQQ----YYQQVQMMQQ 568
            ||::.......|..:...|..    :....:.....|..||...||  |::    |.|::|.|..
  Fly  2217 YSTDTVDGSDVNIHFKTPIRH----EQRQNLSEEELAIRQAEHMQKLYHEERRRKYLQELQDMNS 2277

  Fly   569 QEH----PPQQQQMRQQPSYSSLQEKQSRQSTA--MRVYRAIYDYEAQDVDEVSFREGDVIFEVE 627
            :.|    .|.|:.......|.......:.:|..  ..|.||:::::.|...|:|||:||.|:...
  Fly  2278 RRHTDNFTPSQKSPIALNRYDDFPTDVTLKSLVGPKTVARALFNFQGQTSKELSFRKGDTIYIRR 2342

  Fly   628 SIDSGWMTGRVERTGKTGMLPANYVE 653
            .||:.|..|  |.....|:|||:|||
  Fly  2343 QIDANWYEG--EHNAMIGLLPASYVE 2366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lasp	NP_730192.2	LIM_LASP	5..57	CDD:188831
		Nebulin	67..94	CDD:459977
		NEBU	97..127	CDD:128523	1/13 (8%)
		SH3_Nebulin_family_C	600..654	CDD:212723	23/54 (43%)
CAP	NP_001369075.1	Sorb	1959..2003	CDD:470634	7/43 (16%)
		SH3_Sorbs_1	2315..2367	CDD:212715	23/54 (43%)
		SH3_Sorbs_2	2384..2436	CDD:212716
		SH3_Sorbs_3	2514..2567	CDD:212714